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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Loffler; Bernd-Michael
Address:
Oberrimsingen, DE
No. of patents:
8
Patents:












Patent Number Title Of Patent Date Issued
6133442 Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antago October 17, 2000
Compounds of formula I ##STR1## wherein R.sup.1 signifies phenyl, substituted phenyl or heterocyclyl;R.sup.2 signifies phenyl or substituted phenyl;R.sup.3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, substituted phenyl, heterocyclyl or a residue --CON
6004965 Sulfonamides December 21, 1999
Compounds of the formula: ##STR1## where A, B, R.sup.1 -R.sup.8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these compounds and pharmaceutical compositions c
5962682 Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagon October 5, 1999
Compounds of formula (I) ##STR1## wherein R.sup.1 signifies phenyl, substituted phenyl or heterocyclyl; R.sup.2 signifies phenyl or substituted phenyl; R.sup.3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, substituted phenyl, heterocyclyl or a resid
5856484 Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity January 5, 1999
Compounds of formula I: ##STR1## are disclosed. The compounds inhibit the binding of endothelin to its receptors.
5837708 Sulphonamides November 17, 1998
Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders s
5541186 Sulfonylaminopyrimidines July 30, 1996
A compound of the formula ##STR1## wherein R.sup.1 to R, R.sup.a, R.sup.b X, Y, Z, m and n have the significance given in the description, can be used as medicaments, especially for the treatment and prophylaxix of conditions which are associated with endothelin activities.
5420129 Phenylsulfonylamide pyrimidine May 30, 1995
The invention is concerned with novel sulphonamides and their use as medicaments. In particular, the invention is concerned with compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, halogen or trifluoromethyl;R.sup.2 is hydrog
5292740 Sulfonamides March 8, 1994
The novel sulfonamides of formula I, ##STR1## in which the symbols R.sup.1 -R.sup.9, R.sup.a, R.sup.b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms










 
 
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