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Inventor:
Lewis; Richard Thomas
Address:
Bishops Stortford, GB
No. of patents:
11
Patents:












Patent Number Title Of Patent Date Issued
7851638 Cyclohexanesulfonyl derivatives as GLYT1 inhibitors to treat schizophrenia December 14, 2010
The present invention provides compounds of formula I: ##STR00001## wherein R.sup.1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R.sup.2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R.sup.3 is an alkyl, cycloalkyl, cy
7655644 Piperidine and azetidine derivatives as GlyT1 inhibitors February 2, 2010
The present invention provides compounds of formula (I), wherein both p's are one or two, R.sup.1 is generally heteroaryl or cycloalkyl, R.sup.2 is C.sub.3-6cycloalkyl or phenyl and R.sup.3 is heteroaryl, and pharmaceutically acceptable salts thereof, as GlyT1 inhibitors for treating
7626056 Cyclohexanesulfonyl derivatives as GlyT1 inhibitors to treat schizophrenia December 1, 2009
The present invention provides compounds of formula I: ##STR00001## wherein R.sup.1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R.sup.2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R.sup.3 is an alkyl, cycloalkyl, cyc
7030128 Imidazo-pyrimidine derivatives as ligands for GABA receptors April 18, 2006
A class of imidazo[1,2-.alpha.]pyrimidine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, are selective ligands for GABA.sub.A receptors, in particular having good affinity for the .alpha.2 and/or .alpha.3 and/or
6969716 5-phenyl[1,2,4]triazines as ligands for GABA-A .alpha.2/.alpha.3 receptors for treating anxiety November 29, 2005
The present invention provides a compound of formula I, or an N-oxide thereof or a pharmaceutically acceptable salt thereof: ##STR1##whereinX.sup.1 represents hydrogen, halogen, C.sub.1-6 alkyl, trifluoromethyl or C.sub.1-6 alkoxy;X.sup.2 represents hydrogen or halogen;Z represents hydro
6900215 Imidazo-pyrimidine derivatives as ligands for gaba receptors May 31, 2005
A class of 3-phenylimidazo[1,2-.alpha.]pyrimidine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a --NH-- linkage, and further substituted on the phenyl ring
6730676 Pyrazino-pyridazine derivatives as ligands for GABA receptors May 4, 2004
A class of pyrazino[2,3-d]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 5-position, a substituted alkoxy moiety at the 3-position, and a range of substituents at the 2-position, are selective ligands for GABA.sub.A re
6500828 Triazolo-pyridazine derivatives as ligands for gaba receptors December 31, 2002
1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing a difluoro-or tri-fluoro-substituted phenyl ring at the 3-position, a triazolyl moiety at the 6-position, and a tert-butyl group at the 7-position, are selective ligands for GABA.sub.A receptors, in particular having high affinity f
6333336 Pyrazolo-pyridine derivatives as ligands for GABA receptors December 25, 2001
Pyrazolo[4,3-c]pyridin-3-one derivatives substituted at the 2-position by an optionally substituted aryl or heteroaryl moiety, and having pendant substituents at the 7-position and optionally also at the 6-position, are selective ligands for GABA.sub.A receptors, particularly having high
6133255 Tricyclic pyridone analogues as GABA-A receptor ligands October 17, 2000
Tricyclic pyridin-2-one analogues which are ligands for GABA.sub.A receptors, are useful in the therapy of deleterious mendtal states, and are represented by the formula: ##STR1##
5719149 Morpholine derivatives and their use as therapeutic agents February 17, 1998
The present invention relates to compounds of formula (I) wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are selected from a variety of suitable aromatic substituents; R.sup.6 is hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, phenyl, or










 
 
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