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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Lee; Kuo-Hsiung
Address:
Chapel Hill, NC
No. of patents:
45
Patents:












Patent Number Title Of Patent Date Issued
8198323 Curcumin analogues and uses thereof June 12, 2012
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such
8188089 Tylophorine analogs as antitumor agents May 29, 2012
Compounds of Formula I are described: preferably subject to the proviso that either (a) R.sup.2 and R.sup.3 together form --O--CH(R.sup.10)--O--, or (b) R.sup.5 and R.sup.6 together form --O--CH(R.sup.10)--O--, wherein R.sup.10 is H, halo, or loweralkyl. Pharmaceutical salts, formulation
7795299 Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents September 14, 2010
Compounds of Formulas I-II are described, ##STR00001## along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
7709535 Curcumin analogues and uses thereof May 4, 2010
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such
7671088 Water-soluble etoposide analogs and methods of use thereof March 2, 2010
Etoposide analogs with improved water-solubility such as 4'-O-Demethyl-4'-(N',N'-dimethyl-glycyl)-4.beta.-(4''-nitroanilino)-4-des- oxy-podophyllotoxin (8) and 4'-O-Demethyl-4'-(N',N'-dimethyl-glycyl)-4.beta.-(4''-fluoroanilino)-4-de- soxy-podophyllotoxin (9) are described, along with
7595346 Curcumin analogues and uses thereof September 29, 2009
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such
7495026 Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents February 24, 2009
Compounds of Formulas I-II are described, ##STR00001## along with methods of using such compounds for the treatment of cancer and pharmeutical formulations thereof.
7365221 Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof April 29, 2008
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R.sub.1 is a C.sub.2-C.sub
7355081 Curcumin analogues and uses thereof April 8, 2008
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such
7332615 Hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents February 19, 2008
The present invention discloses hydrophilic derivatives of 4,8-dihydrobenzodithiophene-4,8-diones, which are active as anticancer agents, along with pharmaceutical formulations containing the same.
7282521 Anti-retroviral moronic acid derivatives October 16, 2007
The present invention provides moronic acid derivatives of the general formula: ##STR00001## which have antiviral activity, along with compositions containing the same and methods of use thereof.
7176236 Water-soluble etoposide analogs and methods of use thereof February 13, 2007
Etoposide analogs with improved water-solubility such as 4'-O-Demethyl-4'-(N',N'-dimethyl-glycyl)-4.beta.-(4''-nitroanilino)-4-des- oxy-podophyllotoxin (8) and 4'-O-Demethyl-4'-(N',N'-dimethyl-glycyl)-4.beta.-(4''-fluoroanilino)-4-de- soxy-podophyllotoxin (9) are described, along with
6916831 Flavone acetic acid analogs and methods of use thereof July 12, 2005
Compounds are described having a structure according to Formula I or Formula II: ##STR1##wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n is from 1 to 5; R.sub.1 and R.sub.3 are each independentl
6897316 Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents May 24, 2005
Substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives and their salts were synthesized. The results of preliminary screening revealed that these compounds are potent in killing solid tumor cancers.
6872841 Etoposide analogs and methods of use thereof March 29, 2005
Etoposide analogs such as 4'-O-demethyl-4.beta.-[4"-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy -podophyllotoxin (12) and 4'-O-demethyl-4.beta.-[4"-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-deso xypodophyllotoxin (13) are described, along with pharmaceutical formulations con
6790979 Curcumin analogues and uses thereof September 14, 2004
The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such a
6624317 Taxoid conjugates as antimitotic and antitumor agents September 23, 2003
Compounds according to formula I:wherein T.sub.1 is a taxoid group, preferably of Formula II: ##STR1##wherein R.sub.1 is C.sub.6 H.sub.5 ; R.sub.2 is O; L is a linking group; and T.sub.2 is a substituent selected from the group consisting of epipodophyllotoxin, amsacrine, ellipticine, an
6593334 Camptothecin-taxoid conjugates as antimitotic and antitumor agents July 15, 2003
Compounds according to formula I: C'--L--T (I), wherein C' is a camptothecin group; L is a linking moiety; T is a taxoid group, pharmaceutically acceptable salt thereof. The compounds are useful in, among other things, treating cancer in subjects in need thereof, including cellular d
6569870 Fluorinated quinolones as antimitotic and antitumor agents May 27, 2003
The present invention provides fluorinated quinolones which are fluorinated on the phenyl group thereof, along with pharmaceutical formulations containing the same, methods of treating tumors or cancer by the administration of such compounds, and methods of inhibiting cellular mitosi
6566393 Etoposide analogs and methods of use thereof May 20, 2003
Etoposide analogs such as 4'-O-demethyl-4.beta.-[4"-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy -podophyllotoxin (12) and 4'-O-demethyl-4.beta.-[4"-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-deso xypodophyllotoxin (13) are described, along with pharmaceutical formulations con
6479499 2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceut November 12, 2002
Two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones are synthesized and evaluated for cytotoxicity against a panel of human tumor cell lines, such as epidermoid carcinoma of the nasopharynx (KB), lung
6420377 Covalent conjugates of topoisomerase I and topoisomerase II inhibitors July 16, 2002
The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I:wherein: T.sub.I is a topoisomerase I inhibitor such as a camptothecin group; T.sub.II is a topoisomerase II inhibitor such as a
6337346 Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents January 8, 2002
Compounds useful as cytotoxic agents are selected from the group consisting of compounds of Formula I and compounds of Formula II: ##STR1##wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of: hydrogen, alkyl, carboxy, alkoxy, hy
6319929 Suksdorfin analogs, compositions thereof, and methods for making and using thereof November 20, 2001
The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula IV: ##STR1##wherein R.sup.20 through R.sup.26, M and Z are defined herein. The invention is also directed to pharmaceutic
6229016 Method for treating tumors using 2-aryl-naphthyridin-4-ones May 8, 2001
The present invention provides compounds of Formula I: ##STR1##wherein A and R.sub.1 -R.sub.8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasis,
6207673 Covalent conjugates of topoisomerase I and topoisomerase II inhibitors March 27, 2001
The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I:wherein:T.sub.I is a topoisomerase I inhibitor such as a camptothecin group;T.sub.II is a topoisomerase II inhibitor such as an amsacr
6174918 Naphthoquinone antitumor compound and method January 16, 2001
The invention provides 1,4-naphthoquinone compounds and a method for inhibiting tumor cell growth in a subject by administering such compounds. The compounds are represented by the structures: ##STR1##where R.sub.1 is lower alkyl, halogenated lower alkyl, phenyl, benzyl, phenethyl, o
6174913 Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents January 16, 2001
Compounds useful as cytotoxic agents are selected from the group consisting of compounds of Formula I and compounds of Formula II: ##STR1##wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of: hydrogen, alkyl, carboxy, alkoxy, hy
6172110 Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof January 9, 2001
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have the following formulae: ##STR1##or pharmaceutically acceptable salts thereof, wherein R.sub.1 is a C.sub.2 -C.s
6071930 Method for treating tumors using 2-aryl-naphthyridin-4-ones June 6, 2000
The present invention provides compounds of Formula I: ##STR1## wherein A and R.sub.1 -R.sub.8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psoriasi
5994367 Method for treating tumors using 2-aryl-naphthyridin-4-ones November 30, 1999
The present invention provides compounds of Formula I: ##STR1## wherein A and R.sub.1 -R.sub.8 are defined herein. The compounds of Formula I inhibit the polymerization of tubulin and possess antimitotic activity. The compounds of Formula I may be useful for the treatment of psor
5847165 Suksdorfin analogs, compositions thereof, and methods for making and using thereof December 8, 1998
Disclosed are compounds of Formula I: ##STR1## wherein R.sup.1 through R.sup.6 are defined herein. Also disclosed are pharmaceutical compositions and methods of using these compositions for treating retroviral infections. Finally, a stereoselective method for synthesizing compoun
5789431 Naphthoquinone antitumor compound and method August 4, 1998
The invention provides 1,4-naphthoquinone compounds and a method for inhibiting tumor cell growth in a subject by administering such compounds. The compounds are represented by the structures: ##STR1## where R.sub.1 is lower alkyl, halogenated lower alkyl, phenyl, benzyl, pheneth
5726204 Suksdorfin analogs, compositions thereof, and methods for making and using thereof March 10, 1998
The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein. The invention is also
5679828 Betulinic acid and dihydrobetulinic acid derivatives and uses therefor October 21, 1997
Some betulinic acid and dihydrobetulinic acid acyl derivatives according to the present invention have been found to have potent anti-HIV activity. Introducing a C.sub.2 -C.sub.20 substituted or unsubstituted acyl group at the C.sub.3 -hydroxy group of betulinic acid and dihydrobetulinic
5639793 Mammalian DNA topoisomerase II inhibitor and method June 17, 1997
A novel antiproliferative drug and methods are disclosed. The drug has the general structural formula: ##STR1## where R1=OR.sub.1 ', SR.sub.1 ', or N(R.sub.1 'R.sub.1 ").sub.2, where R.sub.1 ' and R.sub.1 " are H or lower alkyl groups, and R.sub.2 is an acylamino, or aroylamino g
5637589 Suksdorfin, analogs, compositions thereof, and methods for making and using thereof June 10, 1997
Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1): ##STR1## wherein M is O or NH; Z is O, NH or S; R.sup.240, and R.sup.250 are each H, C.sub.1-10 alkyl, C.sub.1-10 aryl, a
5612341 Brominated hexahydroxybiphenyl derivatives March 18, 1997
Disclosed herein are derivatives of 4,4'-dimethoxy-5,6,5'6'-bimethylenedioxy 2,2'-dimethoxycarbonyl biphenyl (DDB) which were synthesized and found to have anti-HIV activity. Of the compounds studied, 3,3'-dibromo DDB and 3-bromo-DDB initially exhibited the greatest anti-HIV activity
5571822 Antitumor compounds November 5, 1996
A method of inhibiting tumor-cell growth in a mammalian subject, by administering a therapeutically effective amount of a selected 2-phenyl-4-quinolone compound. The selected compound shows unexpectely high activity against a variety of solid tumor cells.
5541223 4.beta.-amino podophyllotoxin analog compounds and methods July 30, 1996
Novel podophyllotoxin compounds and their use in treating tumors are disclosed. The analogs have the general formula: ##STR1## wherein NH--R is a selected aryl amine, dialkylaminoalkyleneamino, or dialkylaminoanilino group.
5426224 Mammalian DNA topoisomerase II inhibitor and method June 20, 1995
A novel antiproliferative drug and methods are disclosed. The drug has the general structural formula: ##STR1## where R1=OR.sub.1 ', SR.sub.1 ', or N(R.sub.1 'R.sub.1 ").sub.2, where R.sub.1 ' and R.sub.1 " are H or lower alkyl groups, and R.sub.2 is an acylamino, or aroylamino g
5332811 Etopside analogs July 26, 1994
Compounds which are analogs of etoposide and which exhibit anti-tumor activity are disclosed. These compounds having the following structure: ##STR1## wherein R is selected from ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each independently selected fr
5300500 4 beta-amino podophyllotoxin analog compounds and methods April 5, 1994
Novel podophyllotoxin compounds and their use in treating tumors are disclosed. In one embodiment, the compounds have the general formula: ##STR1## wherein NH-R is a selected from the from the group consisting of: ##STR2##
5132322 Etoposide analogues July 21, 1992
Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: ##STR1## where: R.sub.1 is .beta.-OCH.sub.2 CH.sub.2 NH.sub.2 .beta.-NHCH(CH.sub.3)CH.sub.2 OH, .beta.-NHCH.sub.2 CH(CH.sub.3)O
4350638 Bruceolides September 21, 1982
There are provided two synthetic routes to the known potent anti-leukemic quassinoid bruceantin from the more readily available bruceoside-A and -B. Certain of the intermediate compounds produced in the synthetic sequence as well as bruceantin itself have been shown to possess anti-malar










 
 
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