| Patent Number |
Title Of Patent |
Date Issued |
| RE37303 |
Imidazole compounds and their therapeutic applications |
July 31, 2001 |
| A compound selected from the group consisting of a compound of the formula ##STR1##wherein the substituents are defined as in the specification having antagonist properties to histamine H.sub.3 -receptors. |
| 8222294 |
Combinations of an anti emetic agent and an enkephalinase inhibitor |
July 17, 2012 |
| The present invention concerns combinations of an anti-emetic agent and an enkephalinase inhibitor for use in methods for treating diarrhea and/or gastroenteritis. |
| 8207197 |
Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy] propyl] -piperidine |
June 26, 2012 |
| The invention relates to new crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride, the respective manufacture and methods of use, and compositions containing such a compound. |
| 8106041 |
Combination product comprising an antagonist or inverse agonist of histamine receptor H.sub.3 a |
January 31, 2012 |
| Medicament comprising, in a pharmaceutically acceptable vehicle, an anti-psychotic or an antidepressant (A), which, on its own, has an undesirable effect of a gain in body weight or sedation, and an antagonist and/or inverse agonist (B) of the histamine H.sub.3 receptor, the antagoni |
| 8076329 |
Histamine H3-receptor ligands and their therapeutic applications |
December 13, 2011 |
| The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS |
| 8017646 |
Histamine H.sub.3-receptor ligands and their therapeutic application |
September 13, 2011 |
| The present patent application concerns new compounds of formula (I) with R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached, form a saturated nitrogen-containing ring, A is a saturated C1-4 alkylene and B a C3-4 alkylene or alkenylene chain; their p |
| 7910605 |
Non-imidazole alkylamines as histamine H.sub.3- receptor ligands and their therapeutic applicati |
March 22, 2011 |
| Use of a compound of formula (A), wherein: ##STR00001## W is a residue which imparts antagonistic and/or agonistic activity at histamine H.sub.3-receptors when attached to an imidazole ring in 4(5) position; R.sup.1 and R.sup.2 may be identical or different and represent each indepe |
| 7432269 |
Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as |
October 7, 2008 |
| The invention relates to compounds of the general formula (I): ##STR00001## to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicine |
| 7169928 |
Non-imidazole alkylamines as histamine H.sub.3-receptor ligands and their therapeutic applicatio |
January 30, 2007 |
| Use of a compound of formula (A), wherein: ##STR00001## W is a residue which imparts antagonistic and/or agonistic activity at histamine H.sub.3-receptors when attached to an imidazole ring in 4(5) position; R.sup.1 and R.sup.2 may be identical or different and represent each indepe |
| 7094773 |
LTA.sub.4 hydrolase inhibitors |
August 22, 2006 |
| The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A.sub.4 (LTA.sub.4), and enzyme which is responsible for the biosynthesis of leukotriene LTB.sub.4, a major proinflammatory mediator |
| 6919093 |
Formulation |
July 19, 2005 |
| A dry powder granulated formulation of the compound racedotril and its use in therapy in the treatment of diarrhoea. |
| 6878723 |
LTA4 hydrolase inhibitors |
April 12, 2005 |
| The invention concerns compounds inhibiting LTA.sub.4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. |
| 6835851 |
Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic |
December 28, 2004 |
| The instant invention relates to a process for preparing a compound of formula (I): ##STR1##said process comprising a step (B) which consists in performing a Michael addition of a thioacid RS4H on to an .alpha.-substituted acrylamide derivative.The invention also relates to the enant |
| 6767921 |
Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions co |
July 27, 2004 |
| The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo[1,3]dioxol-5-ylpropionyl-amino)pr opionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical compositions contain |
| 6436973 |
LTA4 hydrolase inhibitors |
August 20, 2002 |
| The invention concerns LTA.sub.4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications. ##STR1## |
| 6248765 |
Imidazole derivatives as histamine receptor H3 (ANT) agonists |
June 19, 2001 |
| Novel imidazole derivatives as histamine receptor H.sub.3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H.sub.3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use |
| 6013829 |
Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl -3- phenyl propan |
January 11, 2000 |
| Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in:a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride;b) preparing the mo |
| 5985895 |
2-naphthamide derivatives and their therapeutic applications |
November 16, 1999 |
| The invention relates to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z-Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group;R.sup.1 represents a hydrogen, fluorine, bromine or io |
| 5945548 |
Process for the synthesis of .alpha.-substituted acrylic acids and their application |
August 31, 1999 |
| Process for the synthesis of .alpha.-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1## |
| 5872119 |
2-Naphthamide derivatives and their therapeutic applications |
February 16, 1999 |
| The invention related to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z--Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group;R.sup.1 represents a hydrogen, fluorine, bromine or i |
| 5786494 |
Process for the synthesis of .alpha.-substituted acrylic acids and their application |
July 28, 1998 |
| Process for the synthesis of a-substituted acrylic acids and their application.Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (II). ##STR1## |
| 5708171 |
Imidazole derivatives for pharmaceutical use |
January 13, 1998 |
| A compound selected from the group consisting of a compound of the formula ##STR1## having antagonist properties to histamine H.sub.3 -receptors. |
| 5670531 |
Amino acid derivatives, the process for their preparation and their applications to therapy |
September 23, 1997 |
| Amino acid derivatives having both enkephalinase and ACE inhibiting properties corresponding to the formula: ##STR1## |
| 5646313 |
Amino acid derivatives, processes for their preparation and their therapeutic application |
July 8, 1997 |
| New amino acid derivatives, processes for their preparation, and their therapeutic application are described.These amino acid derivatives correspond to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity. |
| 5612371 |
Amino acid, derivatives, processes for their preparation and their therapeutic application |
March 18, 1997 |
| New amino acid derivatives, processes for their preparation and their therapeutic application.Amino acid derivatives corresponding to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity. |
| 5599951 |
Amino acid derivatives, the process for their preparation and their applications to therapy |
February 4, 1997 |
| Amino acid derivatives of formula (Ia) and (Ib) and prodrugs thereof containing a group responsible for chelating the zinc atom of enkephalinase and angiotensin convertase enzymes are disclosed as inhibitors of these enzymes. |
| 5559113 |
Imidazole compounds and their therapeutic applications |
September 24, 1996 |
| A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H.sub.3 -receptors. |
| 5498628 |
Naphthamide derivatives |
March 12, 1996 |
| The new naphthamide derivatives according to the invention are characterized in that they correspond to the general formula (I), ##STR1## where X: represents either a hydrogen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphu |
| 5342960 |
Azomethines agonist compounds of the histamine H.sub.3 receptor for therapeutic use, pharmaceuti |
August 30, 1994 |
| Agonist compounds of the histamine H.sub.3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process are disclosed.The compounds are derived from an amine R-NH.sub.2 having a high affinity for the histamine H.sub.3 receptor |
| 5331008 |
Thioester enantiomeric compounds and their therapeutic uses |
July 19, 1994 |
| The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and |
| 5296509 |
Thioester enantiomeric compounds and their therapeutic uses |
March 22, 1994 |
| The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and |
| 5290790 |
4-(4-imidazolyl) piperidines substituted at position 1, their preparation and also their therape |
March 1, 1994 |
| The compounds correspond to the general formula ##STR1## in which R.sub.1 represents a hydrogen atom or a group --COR.sub.2, in which R.sub.2 represents a benzene ring, cyclopentylmethyl, cyclohexylmethyl, cyclopentylethyl or cyclohexylethyl groups or cyclopentylamine, cyclohexyl |
| 5208255 |
Thioester enantiomeric compounds and their therapeutic uses |
May 4, 1993 |
| The (R) or (S) isomer of acetorphan or N-/2-acetylthiomethyl)-1-oxo-3-phenylpropyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-2-benzylpropanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coup |
| 5136076 |
Process for the preparation of amino acid-derived enatiomeric compounds |
August 4, 1992 |
| The (R) or (S) isomer of acetorphan or N-12-acetylthiomethyl-1-oxo-3-phenyl propyl/(S) alanine methyl ester is prepared by splitting of racemic 3-acetylthio-2-benzyl propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupl |
| 4707487 |
(4-imidazolyl)piperidines, the preparation thereof and their application in therapy |
November 17, 1987 |
| Compounds of general formula ##STR1## in which R.sub.1 denotes H, CH.sub.3 or C.sub.2 H.sub.5, R denotes H or R.sub.2 and R.sub.2 denotes an alkyl, piperonyl, 3-(1-benzimidazolonyl)-propyl group; a group of formula ##STR2## in which n is 0, 1, 2, or 3, X is a single bond or a |
| 4513009 |
Aminoacid derivatives and their therapeutic applications |
April 23, 1985 |
| This invention relates to aminoacid derivatives, and compositions containing the same and having enkephalinase-inhibiting, antalgic, antidiarrhea and hypotensive activities, of the formula ##STR1## whose variables are as set forth herein, for example ##STR2## |
| 4407794 |
Peptides and therapeutic applications thereof |
October 4, 1983 |
| This invention relates to peptide derivatives of the formula:in which:A is a D.Ala, AzaGly, Aib, D.Ser., D.Thr, D.Cys, homo Serine, .beta.Phe Ser, .beta.OH Leu, 4OH Ile, .alpha.,.beta.,.gamma. OHNor Val or OH Val residue in which the side-chain OH or SH groups, when same exist, may be fr |
