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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Lecomte; Jeanne-Marie
Address:
Paris, FR
No. of patents:
37
Patents:












Patent Number Title Of Patent Date Issued
RE37303 Imidazole compounds and their therapeutic applications July 31, 2001
A compound selected from the group consisting of a compound of the formula ##STR1##wherein the substituents are defined as in the specification having antagonist properties to histamine H.sub.3 -receptors.
8222294 Combinations of an anti emetic agent and an enkephalinase inhibitor July 17, 2012
The present invention concerns combinations of an anti-emetic agent and an enkephalinase inhibitor for use in methods for treating diarrhea and/or gastroenteritis.
8207197 Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy] propyl] -piperidine June 26, 2012
The invention relates to new crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride, the respective manufacture and methods of use, and compositions containing such a compound.
8106041 Combination product comprising an antagonist or inverse agonist of histamine receptor H.sub.3 a January 31, 2012
Medicament comprising, in a pharmaceutically acceptable vehicle, an anti-psychotic or an antidepressant (A), which, on its own, has an undesirable effect of a gain in body weight or sedation, and an antagonist and/or inverse agonist (B) of the histamine H.sub.3 receptor, the antagoni
8076329 Histamine H3-receptor ligands and their therapeutic applications December 13, 2011
The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS
8017646 Histamine H.sub.3-receptor ligands and their therapeutic application September 13, 2011
The present patent application concerns new compounds of formula (I) with R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached, form a saturated nitrogen-containing ring, A is a saturated C1-4 alkylene and B a C3-4 alkylene or alkenylene chain; their p
7910605 Non-imidazole alkylamines as histamine H.sub.3- receptor ligands and their therapeutic applicati March 22, 2011
Use of a compound of formula (A), wherein: ##STR00001## W is a residue which imparts antagonistic and/or agonistic activity at histamine H.sub.3-receptors when attached to an imidazole ring in 4(5) position; R.sup.1 and R.sup.2 may be identical or different and represent each indepe
7432269 Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as October 7, 2008
The invention relates to compounds of the general formula (I): ##STR00001## to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicine
7169928 Non-imidazole alkylamines as histamine H.sub.3-receptor ligands and their therapeutic applicatio January 30, 2007
Use of a compound of formula (A), wherein: ##STR00001## W is a residue which imparts antagonistic and/or agonistic activity at histamine H.sub.3-receptors when attached to an imidazole ring in 4(5) position; R.sup.1 and R.sup.2 may be identical or different and represent each indepe
7094773 LTA.sub.4 hydrolase inhibitors August 22, 2006
The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A.sub.4 (LTA.sub.4), and enzyme which is responsible for the biosynthesis of leukotriene LTB.sub.4, a major proinflammatory mediator
6919093 Formulation July 19, 2005
A dry powder granulated formulation of the compound racedotril and its use in therapy in the treatment of diarrhoea.
6878723 LTA4 hydrolase inhibitors April 12, 2005
The invention concerns compounds inhibiting LTA.sub.4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
6835851 Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic December 28, 2004
The instant invention relates to a process for preparing a compound of formula (I): ##STR1##said process comprising a step (B) which consists in performing a Michael addition of a thioacid RS4H on to an .alpha.-substituted acrylamide derivative.The invention also relates to the enant
6767921 Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions co July 27, 2004
The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo[1,3]dioxol-5-ylpropionyl-amino)pr opionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical compositions contain
6436973 LTA4 hydrolase inhibitors August 20, 2002
The invention concerns LTA.sub.4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications. ##STR1##
6248765 Imidazole derivatives as histamine receptor H3 (ANT) agonists June 19, 2001
Novel imidazole derivatives as histamine receptor H.sub.3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H.sub.3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use
6013829 Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl -3- phenyl propan January 11, 2000
Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in:a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride;b) preparing the mo
5985895 2-naphthamide derivatives and their therapeutic applications November 16, 1999
The invention relates to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z-Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group;R.sup.1 represents a hydrogen, fluorine, bromine or io
5945548 Process for the synthesis of .alpha.-substituted acrylic acids and their application August 31, 1999
Process for the synthesis of .alpha.-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##
5872119 2-Naphthamide derivatives and their therapeutic applications February 16, 1999
The invention related to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z--Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group;R.sup.1 represents a hydrogen, fluorine, bromine or i
5786494 Process for the synthesis of .alpha.-substituted acrylic acids and their application July 28, 1998
Process for the synthesis of a-substituted acrylic acids and their application.Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (II). ##STR1##
5708171 Imidazole derivatives for pharmaceutical use January 13, 1998
A compound selected from the group consisting of a compound of the formula ##STR1## having antagonist properties to histamine H.sub.3 -receptors.
5670531 Amino acid derivatives, the process for their preparation and their applications to therapy September 23, 1997
Amino acid derivatives having both enkephalinase and ACE inhibiting properties corresponding to the formula: ##STR1##
5646313 Amino acid derivatives, processes for their preparation and their therapeutic application July 8, 1997
New amino acid derivatives, processes for their preparation, and their therapeutic application are described.These amino acid derivatives correspond to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.
5612371 Amino acid, derivatives, processes for their preparation and their therapeutic application March 18, 1997
New amino acid derivatives, processes for their preparation and their therapeutic application.Amino acid derivatives corresponding to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.
5599951 Amino acid derivatives, the process for their preparation and their applications to therapy February 4, 1997
Amino acid derivatives of formula (Ia) and (Ib) and prodrugs thereof containing a group responsible for chelating the zinc atom of enkephalinase and angiotensin convertase enzymes are disclosed as inhibitors of these enzymes.
5559113 Imidazole compounds and their therapeutic applications September 24, 1996
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H.sub.3 -receptors.
5498628 Naphthamide derivatives March 12, 1996
The new naphthamide derivatives according to the invention are characterized in that they correspond to the general formula (I), ##STR1## where X: represents either a hydrogen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphu
5342960 Azomethines agonist compounds of the histamine H.sub.3 receptor for therapeutic use, pharmaceuti August 30, 1994
Agonist compounds of the histamine H.sub.3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process are disclosed.The compounds are derived from an amine R-NH.sub.2 having a high affinity for the histamine H.sub.3 receptor
5331008 Thioester enantiomeric compounds and their therapeutic uses July 19, 1994
The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and
5296509 Thioester enantiomeric compounds and their therapeutic uses March 22, 1994
The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and
5290790 4-(4-imidazolyl) piperidines substituted at position 1, their preparation and also their therape March 1, 1994
The compounds correspond to the general formula ##STR1## in which R.sub.1 represents a hydrogen atom or a group --COR.sub.2, in which R.sub.2 represents a benzene ring, cyclopentylmethyl, cyclohexylmethyl, cyclopentylethyl or cyclohexylethyl groups or cyclopentylamine, cyclohexyl
5208255 Thioester enantiomeric compounds and their therapeutic uses May 4, 1993
The (R) or (S) isomer of acetorphan or N-/2-acetylthiomethyl)-1-oxo-3-phenylpropyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-2-benzylpropanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coup
5136076 Process for the preparation of amino acid-derived enatiomeric compounds August 4, 1992
The (R) or (S) isomer of acetorphan or N-12-acetylthiomethyl-1-oxo-3-phenyl propyl/(S) alanine methyl ester is prepared by splitting of racemic 3-acetylthio-2-benzyl propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupl
4707487 (4-imidazolyl)piperidines, the preparation thereof and their application in therapy November 17, 1987
Compounds of general formula ##STR1## in which R.sub.1 denotes H, CH.sub.3 or C.sub.2 H.sub.5, R denotes H or R.sub.2 and R.sub.2 denotes an alkyl, piperonyl, 3-(1-benzimidazolonyl)-propyl group; a group of formula ##STR2## in which n is 0, 1, 2, or 3, X is a single bond or a
4513009 Aminoacid derivatives and their therapeutic applications April 23, 1985
This invention relates to aminoacid derivatives, and compositions containing the same and having enkephalinase-inhibiting, antalgic, antidiarrhea and hypotensive activities, of the formula ##STR1## whose variables are as set forth herein, for example ##STR2##
4407794 Peptides and therapeutic applications thereof October 4, 1983
This invention relates to peptide derivatives of the formula:in which:A is a D.Ala, AzaGly, Aib, D.Ser., D.Thr, D.Cys, homo Serine, .beta.Phe Ser, .beta.OH Leu, 4OH Ile, .alpha.,.beta.,.gamma. OHNor Val or OH Val residue in which the side-chain OH or SH groups, when same exist, may be fr










 
 
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