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Inventor:
Kuroiwa; Katsumasa
Address:
Koriyama, JP
No. of patents:
27
Patents:












Patent Number Title Of Patent Date Issued
5719030 Monoclonal antibody to prostate-derived acid phosphatase and method for determination of acid ph February 17, 1998
According to the present invention, there are provided a monoclonal antibody to prostate-derived acid phosphatase and a method for determination of prostate-derived acid phosphatase using the monoclonal antibody. Prostate-derived acid phosphatase is boostered in animal and spleen cel
5508385 Tripeptide derivatives containing pyroglutamic acid residue April 16, 1996
Novel tripeptide derivatives having a pyroglutamic acid residue strongly inhibit a plurality of trypsin-like serine proteases such as plasmin, thrombin, trypsin, kallikrein, factor Xa and urokinase. The compounds of the present invention can inhibit various trypsin-like serine proteases
5416238 L-argininal acetal derivatives and a process for production thereof May 16, 1995
Novel N.sup.G -protected or unprotected-L-argininal-dibutyl acetals (I) can be prepared from L-argininal derivatives (III) merely by reacting in an azeotropic solvent in the presence of p-toluenesulfonic acid. In the products (I), L-form amounts to more than 99%, without further optical
5399488 Method for assaying enzyme activity using N-acetyl-.beta.-D-glucosamine derivatives March 21, 1995
Novel N-acetyl-.beta.-D-glucosamine derivatives and a method for assaying N-acetyl-.beta.-D-glucosaminidase activity using the same as substrate are provided.N-Acetyl-.beta.-D-glucosamine derivatives represented by general formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2
5227291 Method for determination of acid phosphatase activity using 4-acyl-2, 6-dihalophenyl phosphoric July 13, 1993
Phosphoric acid derivatives represented by formula (I): ##STR1## wherein X is a halogen and R is --(CH.sub.2).sub.n CH.sub.3 (n=0 to 3), or salts thereof are stable to non-enzymatic hydrolysis and are capable of specifically reacting with acid phosphatase. Therefore, the activity of
5153176 Tripeptide derivatives and protease inhibitor composition comprising the same October 6, 1992
Tripeptide derivatives of formula (I) such as N-.epsilon.-(p-tosyl)-D-lysyl-L-prolyl-L-argininal have an activity of inhibiting a plurality of trypsin-like serine proteases, e.g., plasmin, thrombin, trypsin, kallikrein, factor Xa, urokinase, etc. in vivo. The tripeptide derivatives c
5151372 Method for determination of hydroxyacetophenone derivatives September 29, 1992
There is provided a method for determination of hydroxyacetophenone derivatives such as 3,5-dichloro-4-hydroxyacetophenone in the presence of protein such as albumins or globulins with high sensitivity. The hydroxyacetophenone derivative can be measured in the neutral to acidic regio
5116941 Peptide substrates for determination of enzyme activity May 26, 1992
Compounds represented by the following formula: ##STR1## wherein A.sub.1 and A.sub.2 each represents a specific amino acid residue, are excellent as substrates for determination of enzyme activity such as trypsin, etc.
5115099 Substrates for determination of enzyme activity and intermediates for synthesis of the substrate May 19, 1992
Novel compounds represented by the following formula: ##STR1## wherein A represents a specific amino acid residue are excellent as substrates for determination of enzyme activity such as trypsin, etc. The compounds can be synthesized from novel arginyl-3-tert-alkyloxycarbonyl-4-n
5081274 4-acyl-2,6-dihalophenyl-phosphoric acid derivatives useful in the determination of acid phosphat January 14, 1992
Phosporic acid derivatives represented by formula (I): ##STR1## wherein X is a halogen and R is --(CH.sub.2).sub.n CH.sub.3 (n=0 to 3), or salts thereof are stable to non-enzymatic hydrolysis and are capable of specifically reacting with acid phosphatase. Therefore, the activity of
5063152 Synthetic peptidic substrate for determination of trypsin and .alpha..sub.1 November 5, 1991
A synthetic peptide of the formula: H-.sub.D -A.sub.1 -Leu-Lys-NH ##STR1## wherein A.sub.1 is Pro or Ala, is excellent in solubility in water and substrate specificity and is suitable as a substrate for determining trypsin and .alpha..sub.1 -antitrypsin.
4894438 Synthetic peptidic substrate for determination of trypsin and .alpha..sub.1 January 16, 1990
A synthetic peptide of the formula: ##STR1## wherein A.sub.1 is Pro or Ala, is excellent in solubility in water and substrate specificitity and is suitable as a substrate for determining trypsin and .alpha..sub.1 -antitrypsin.
4883863 Tripeptide derivatives and antiplasmin agents containing the same November 28, 1989
Tripeptide derivatives of the formula:wherein A, B and C are each one of a specific range of substituents, and aaa, Phe and Lys are each of a specific range of amino acid residues, are potent inhibitors of plasmin and useful for prevention or suppression of hemorrhage and for inhibition
4861713 Novel method for determining cholinesterase activity August 29, 1989
This invention relates to a method for determination of cholinesterase activity, characterized by using, as a substrate, a choline derivative represented by the general formula (I): ##STR1## wherein X is a halogen atom; Y.sub.1 is a hydroxyl group as a substituent in the 2- or 5-
4816562 Novel substrate for plasma kallikrein and a method for measuring biological components using the March 28, 1989
Novel compounds represented by the following general formula (1) and salts thereof: ##STR1## wherein n represents an integer of 3 to 4, R.sup.1 represents ##STR2## or --SO.sub.2 R.sup.2, and R.sup.2 represents optionally branched lower alkyl group having 1 to 6 carbon atoms,
4717659 Novel method for determining cholinesterase activity January 5, 1988
In a method for determining cholinesterase (hereinafter referred to as ChE) activity, the improvement comprising by using, as a substrate, a protocatechuoylcholine derivative represented by the general formula (I), ##STR1## (wherein X is a halogen atom). The method for determining Ch
4650753 Novel substrates for use in measuring the concentration of kallikrein in urine March 17, 1987
A novel chromogenic and fluorescent substrate for measuring the concentration of kallikrein in urine. The novel substrate according to the present invention has very excellent substrate specificity to kallikreins and good solubility in water or biological test solutions.The present subst
4622389 Novel substrate for determining the activity of blood coagulation factor Xa (Stuart-Prower facto November 11, 1986
A novel chromogenic and fluorescent substrate for determining the activity of blood coagulation factor Xa and Xa-like enzymes. The novel substrate according to the present invention has very excellent selectivity as compared with the hitherto disclosed substrates and enables specific
4605614 Method for measuring plasmin August 12, 1986
A method for measuring the activity of plasmin in plasma which comprises reacting a compound of the following formula or a salt thereof; ##STR1## with plasmin in a buffer solution having a pH of 7.2 to 7.6 and quantitatively determining the reaction product thereof.
4584398 Arginyl-3-carboxy-4-hydroxyanilide April 22, 1986
Novel arginyl-3-carboxy-4-hydroxyanilide of the formula ##STR1## and acid addition salts thereof are of use as starting materials for preparing chromophoric and fluorescent substrates for measurement of enzyme activity.
4564695 Process for producing arginyl-p-nitroanilide January 14, 1986
An N.sup..alpha. -protected-N.sup.G -protected-arginyl-p-nitro-anilide with high purity can be produced in high yield by reacting an N.sup..alpha. -protected-N.sup.G -protected-arginine with p-nitroaniline in pyridine in the presence of a condensing agent.
4520100 Method for measuring thrombin May 28, 1985
A novel substrate for measuring thrombin which has chromophoric and fluorescent properties on thrombin or a thrombin-like enzymes and is represented by a compound of the following general formula or a salt thereof: ##STR1## wherein R represents ##STR2##
4452736 Substrates for measuring plasmin June 5, 1984
A novel substrate for measuring plasmin which has chromophoric and fluoroescent properties against plasmin or a plasmin-like enzyme, which is characterized by being a compound of the formula or a salt thereof: ##STR1## wherein ##STR2## wherein ##STR3## .
4450105 Substrates for measuring thrombin May 22, 1984
A novel substrate for measuring thrombin which has chromophoric and fluorescent properties on thrombin or a thrombin-like enzymes and is represented by a compound of the following general formula or a salt thereof: ##STR1##
4336331 Method for assaying the activity of .gamma.-glutamyl transpeptidase in serum June 22, 1982
Novel L-.gamma.-glutamyl-3-carboxy-4-hydroxyanilide of the formula, ##STR1## an acid addition salt thereof, or an alkali metal or amine salt thereof, which is useful for determining the activity of .gamma.-glutamyl transpeptidase.
4281181 Novel L-.gamma.-glutamyl-3-carboxy-4-hydroxyanilide and salts thereof July 28, 1981
Novel L-.gamma.-glutamyl-3-carboxy-4-hydroxyanilide of the formula, ##STR1## an acid addition salt thereof, or an alkali metal or amine salt thereof, which is useful for determining the activity of .gamma.-glutamyl transpeptidase.
4209459 Novel L-leucyl-4-hydroxyanilide derivatives June 24, 1980
Novel L-leucyl-4-hydroxyanilide derivatives of the formula, ##STR1## wherein R represents a carboxyl group or a sulfo group or an acid addition salt thereof, which are useful for assay of leucine-aminopeptidase activity.










 
 
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