| Patent Number |
Title Of Patent |
Date Issued |
| 7553619 |
Detection method using dissociated rolling circle amplification |
June 30, 2009 |
| Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a DNA circle with the analyte and subsequent release and rolling circle replication of the circular DNA molecule. In the method, an amplificati |
| 6977153 |
Rolling circle amplification of RNA |
December 20, 2005 |
| Disclosed are compositions and methods for amplification of RNA molecules. The disclosed method involves synthesizing first strand cDNA molecules from RNA molecules, circularizing the first strand cDNA molecules and replicating the circularized first strand cDNA molecules using rolling |
| 6811986 |
5'-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotid |
November 2, 2004 |
| The present invention provides a novel method for ligation of oligonucleotides containing 5'-phosphorothioates on complementary templates by the action of DNA ligases. This reaction is readily applied to the synthesis of a single stranded circular DNA containing a phosphorothioate li |
| 6686157 |
Signal amplification with lollipop probes |
February 3, 2004 |
| Disclosed is a method and compositions for the sensitive detection of the amount and location of specific nucleic acid sequences. The method makes use of a branched oligomer, referred to as a lollipop oligomer, that has a tail portion, a right arm portion, and a left arm portion. These t |
| 6635425 |
5'-thio phosphate directed ligation of oligonucleotides and use in detection of single nucleotid |
October 21, 2003 |
| The present invention provides a novel method for ligation of oligonucleotides containing 5'-phosphorothioates on complementary templates by the action of DNA ligases. This reaction is readily applied to the synthesis of a single stranded circular DNA containing a phosphorothioate li |
