| Patent Number |
Title Of Patent |
Date Issued |
| RE33072 |
Benzothiazepine derivatives |
September 26, 1989 |
| Vasodilating activity is exhibited by compounds having the formula ##STR1## n is 2 or 3; X is oxygen or sulfur,R.sub.1 and R.sub.2 are each independently hydrogen alkyl, cycloalkyl, or allyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are pyrrol |
| 5116851 |
Pharmaceutical composition and method for treating cardiovascular diseases using substituted ani |
May 26, 1992 |
| A novel pharmaceutical composition and method is disclosed for the treatment of cardiovascular diseases, e.g. myocardial ischemia and/or arrhythmia. The method and composition include an effective amount of a compound of the formula ##STR1## wherein X, Y, R, R.sub.1, A, A', m, n, |
| 4963671 |
Process for resolving chiral intermediates used in making calcium channel blockers |
October 16, 1990 |
| This process enables preparation of the preferred (+)-threo enantiomer by resolution of its racemic mixture of a compound of the formula ##STR1## wherein Y.sup.1 and Y.sup.2 are each independently lower alkyl and R.sup.1 is hydrogen or lower alkyl. The compound is treated with a chir |
| 4952692 |
Benzazepine derivatives |
August 28, 1990 |
| Novel compounds of the formula ##STR1## exhibit calcium channel blocking activity and are useful as cardiovascular agents. |
| 4946840 |
Benzazepine and benzothiazepine derivatives |
August 7, 1990 |
| Vasodilating activity is exhibited by compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein X is --CH.sub.2 -- or --S--;R.sub.1 is ##STR2## or --O--Y.sub.3 ; R.sub.2 is heterocyclo or heteroaryl;R.sub.3 and R.sub.4 are each independentl |
| 4902684 |
Benzazepine and benzothiazepine derivatives |
February 20, 1990 |
| Vasodilating activity is exhibited by compounds having the formula ##STR1## wherein X can be --S--or --CH.sub.2 --; andR.sub.2 is ##STR2##depending upon the definition of X. |
| 4752645 |
Benzazepine derivatives |
June 21, 1988 |
| Vasodilating activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof. |
| 4748239 |
Benzazepine derivatives |
May 31, 1988 |
| Vasodilating activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof. |
| 4709046 |
Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds |
November 24, 1987 |
| Spiro compounds of the formula ##STR1## wherein X is oxygen or sulfur. These compounds possess antgiotensin converting enzyme inhibition activity and are thus useful as anti-hypertension agents. |
| 4584131 |
Benzothiazepine derivatives |
April 22, 1986 |
| Vasodilating activity is exhibited by compounds having the formula ##STR1## n is 2 or 3; X is oxygen or sulfur;R.sub.1 and R.sub.2 are each independently hydrogen alkyl, cycloalkyl, or allyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are pyrrol |
| 4578474 |
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
March 25, 1986 |
| Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension. |
| 4499287 |
Certain-4-hydroxy-proline derivatives |
February 12, 1985 |
| Compounds of the formula ##STR1## are useful as intermediates in the preparation of various hypotensive agents. |
| 4497953 |
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
February 5, 1985 |
| Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension. |
| 4468519 |
Esters of phosphinylalkanoyl substituted prolines |
August 28, 1984 |
| Hypotensive activity is exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl;R.sub.2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl-3-cyclohexenyl;R.sub.3 is alkyl, cycloalkyl, phenyl or alkoxy;R.sub.4 is |
| 4462943 |
Carboxyalkyl amino acid derivatives of various substituted prolines |
July 31, 1984 |
| Carboxyalkyl dipeptides of the formula ##STR1## wherein R.sub.4 is a 3-, 4-, 5-, or 4,4-substituted proline are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity. |
| 4456761 |
4-Substituted dehydroprolines |
June 26, 1984 |
| Compounds of the formula ##STR1## are useful as intermediates in the preparation of various hypotensive agents. |
| 4390695 |
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
June 28, 1983 |
| Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension. |
| 4356182 |
Mercaptoacyl derivatives of 4-disubstituted prolines |
October 26, 1982 |
| This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity. |
| 4316906 |
Mercaptoacyl derivatives of substituted prolines |
February 23, 1982 |
| New mercaptoacyl derivatives of substituted prolines which have the general formula ##STR1## are useful as hypotensive agents. |
| 4316905 |
Mercaptoacyl derivatives of various 4-substituted prolines |
February 23, 1982 |
| This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity. |
| 4311697 |
Derivatives of mercaptoacyl prolines and pipecolic acids |
January 19, 1982 |
| This invention is directed to compounds of the formula ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity. |
| 4310461 |
Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
January 12, 1982 |
| Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids are useful for the treatment of hypertension. |
| 4291040 |
Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
September 22, 1981 |
| This invention is directed to compounds of the formulas ##STR1## and various intermediates therefore. The final products possess useful hypotensive activity. |
| 4267354 |
Substituted amides having antiinflammatory activity and intermediates |
May 12, 1981 |
| Compounds having the formula ##STR1## wherein R.sub.1 is alkoxycarbonyl, amido, alkylamido, or dialkylamido; R'.sub.3 is alkylbenzylamino, dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, or 4-alkyl-1-piperazinyl; A.sub.1 is an alkylene group having 2 to 5 carbon atoms |
| 4252943 |
Carbamate derivatives of mercaptoacyl hydroxy prolines |
February 24, 1981 |
| New carbamate derivatives of mercaptoacyl hydroxy prolines which have the general formula ##STR1## are useful as hypotensive agents. |
| 4243804 |
Heterocyclic containing amines |
January 6, 1981 |
| Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; R.sub.4 is alkoxy; A.sub.1 is a saturat |
| 4234602 |
Naphthalenone derivatives and analogs |
November 18, 1980 |
| Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or aryl; R.sub.2 is alkylamino, dialkylamino, or a nitrogen containing heterocyclic group; R.sub.3 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl; A.sub.1 is an alkylene group; and n is 1, 2 or 3, ha |
| 4232027 |
1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives |
November 4, 1980 |
| 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives are provided having the structure ##STR1## wherein (CH.sub.2).sub.n represents a straight chain alkylene group containing 2 to 5 carbons, and R.sub.1 and R.sub.2 are the same or different and may be hydrogen or lower |
| 4217359 |
Carbamate derivatives of mercaptoacyl hydroxy prolines |
August 12, 1980 |
| New carbamate derivatives of mercaptoacyl hydroxy prolines which have the general formula ##STR1## are useful as hypotensive agents. |
| 4216335 |
Azo methine containing compounds |
August 5, 1980 |
| Compounds having the formulas ##STR1## wherein R.sub.1 is alkoxycarbonyl, amido, alkylamido, or dialkylamido; R.sub.3 ' is alkylbenzylamino, dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, or 4-alkyl-1-piperazinyl; A.sub.1 is an alkylene group having 2 to 5 carbon ato |
| 4214081 |
Imino containing morpholine compounds |
July 22, 1980 |
| Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; R.sub.4 is alkoxy; A.sub.1 is a saturat |
| 4199528 |
Substituted amides having antiinflammatory activity |
April 22, 1980 |
| Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; R.sub.4 is alkoxy; A.sub.1 is a saturat |
| 4179558 |
Naphthalenone derivatives and analogs |
December 18, 1979 |
| Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl or aryl; R.sub.2 is alkylamino, dialkylamino, or a nitrogen containing heterocyclic group; R.sub.3 is hydrogen, halogen, alkyl, alkoxy or trifluoromethyl; A.sub.1 is an alkylene group; and n is 1, 2 or 3, ha |
| 4174317 |
3,3-Dichloro-2-azetidinone derivatives |
November 13, 1979 |
| Compounds having the formula ##STR1## wherein A.sub.1 is an alkylene group having 2 to 4 carbon atoms; R.sub.1 is dialkylamino or a nitrogen containing heterocyclic group and R.sub.2 is phenyl, substituted phenyl, naphthyl, or 1,3-benzodioxol-5-yl; have antiinflammatory activity. |
| 4173634 |
Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents |
November 6, 1979 |
| Compounds of the structure ##STR1## are provided, wherein n is 1, 2 or 3, m is 2, 3 or 4, X and Y may be the same or different and are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio or trifluoromethyl, and B is di-lower alkylamino, piperidino, pyrrolidino, morpholi |
| 4166907 |
3,3-Dichloro-2-azetidinone derivatives having antiinflammatory activity |
September 4, 1979 |
| Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is dialkylamino or a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 car |
| 4166072 |
Substituted amides having antiinflammatory activity |
August 28, 1979 |
| Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkoxycarbonyl, amido or substituted amido; R.sub.2 is acyl or sulfonyl; R.sub.3 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; A.sub.1 is an alky |
| 4156079 |
Substituted amides having antiinflammatory activity |
May 22, 1979 |
| Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; R.sub.4 is alkoxy; A.sub.1 is a saturat |
| 4151354 |
Substituted amides and sulfonamides having antiinflammatory activity |
April 24, 1979 |
| Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group havi |
| 4145541 |
3,3-Dichloro-2-azetidinone derivatives having basic substituents |
March 20, 1979 |
| Compounds having the formula ##STR1## wherein X is oxygen or sulfur; R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 t |
| 4127606 |
Substituted sulfonamides having antiinflammatory activity |
November 28, 1978 |
| Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is sulfonyl; R.sub.3 is alkylamino or dialkylamino; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group having 2 to 5 carbon atoms |
| 4122255 |
Substituted amides and sulfonamides containing a heterocyclic group having antiinflammatory acti |
October 24, 1978 |
| Compounds having the formula ##STR1## wherein R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is acyl or sulfonyl; R.sub.3 is a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene group havi |
| 4118558 |
2-Aryl-6-arylidene-1-(substituted aminoalkoxy)-1-cyclohexenes |
October 3, 1978 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 1-piperazinyl, or 4-alkyl-1-piperazinyl, R.sub.2 and R.sub.3 are hydrogen, chloro, fluoro, alkyl, alkoxy or trifluoromethyl, and A |
| 4115382 |
3,3-Dichloro-2-azetidinone derivatives having basic substituents |
September 19, 1978 |
| Compounds having the formula ##STR1## wherein X is oxygen or sulfur; R.sub.1 is alkyl, cycloalkyl or aryl; R.sub.2 is dialkylamino or a nitrogen containing heterocyclic group; A.sub.1 is a saturated bond or an alkylene group having 1 to 4 carbon atoms; and A.sub.2 is an alkylene |
| 4098789 |
Omega-(n-aminoalkoxybenzyl-amino)-(n-hydrocarbonoyl-amino)-alkanoic acid esters |
July 4, 1978 |
| Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkoxycarbonyl, amido or substituted amido; R.sub.2 is acyl or sulfonyl; R.sub.3 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; A.sub.1 is an alky |
| 4085280 |
7-Aminoalkyl-3,7-diaryl-3,3a,4,5,6,7-hexahydro-2H-indazoles |
April 18, 1978 |
| Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkylamino, dialkylamino or a nitrogen containing heterocyclic group; R.sub.2 and R.sub.3 are the same or different and are hydrogen, chloro, fluoro, alkyl, alkoxy or trifl |
| 4085142 |
2-Aryl-6-arylidene-1-(substituted aminoalkoxy)-1-cyclohexenes |
April 18, 1978 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkylamino or dialkylamino, R.sub.2 and R.sub.3 are hydrogen, chloro, fluoro, alkyl, alkoxy or trifluoromethyl, and A.sub.1 is alkylene have antiinflammatory activity. |
| 4085102 |
2-Amino-8-arylideno-3,4,5,6,7,8-hexahydro-4-arlypyrido[4,3-d]pyrimidines |
April 18, 1978 |
| Compounds of the formula ##STR1## and the pharmaceutically acceptable acid-addition salts thereof wherein R.sup.1 and R.sup.2 are hydrogen or alkyl of 1 to 4 carbons; R is hydrogen, alkyl of 1 to 4 carbons, alkanoyl of 2 to 5 carbons, or ##STR2## WHEREIN N IS 1, 2, OR 3; R.su |
| 4078062 |
Substituted 2H-1,4-benzothiazin-3(4H)-ones |
March 7, 1978 |
| Compounds of the following formula and their pharmaceutically acceptable salts ##STR1## wherein X and X.sub.1 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, nitro, or amino; R is hydrogen, lower alkyl, or ##STR2## wherein m |
| 4065617 |
2-(2,2,2,-Trifluoroet hyl)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridines |
December 27, 1977 |
| Antiinflammatory activity is demonstrated by compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, chloro, fluoro, alkyl, alkoxy or trifluoromethyl and R.sub.2 is hydrogen, alkyl, arylalkyl, hydroxyalkyl, or carboximidamide, or pharmaceutically acceptable salts thereof. |
