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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Kozlowski; Antoni
Address:
Huntsville, AL
No. of patents:
60
Patents:


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Patent Number Title Of Patent Date Issued
8568705 Method for preparing branched functionalized polymers using branched polyol cores October 29, 2013
A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol
8563651 Method involving 1-benzotriazolyl carbonate esters of poly(ethylene glycol) October 22, 2013
The invention provides a method comprising the steps of providing a poly(ethylene glycol) having one terminal hydroxyl group; reacting the terminal hydroxyl group of the poly(ethylene glycol) with di(1-benzotriazolyl)carbonate to form a 1-benzotriazolylcarbonate ester of the poly(eth
8562965 Polymer derivatives comprising an acetal or ketal branching point October 22, 2013
The invention provides a polymer comprising (i) a first water-soluble polymer segment that is covalently attached, either directly or through one or more atoms, to a first oxygen atom that is covalently attached to a linking carbon atom; (ii) a second water-soluble polymer segment is
8299173 Method involving 1-benzotriazolyl carbonate esters of polymers October 30, 2012
The invention provides a method comprising the steps of (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate e
8258324 Intermediates useful in the preparation of maleimide functionalized polymers September 4, 2012
Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for prep
8227558 Method for preparing polymer maleimides July 24, 2012
Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are related compositions.
8227555 Hydrolytically stable maleimide-terminated polymers July 24, 2012
The present invention is directed to conjugates of hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
8217123 Stabilized polymeric thiol reagents July 10, 2012
Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y--S--W].sub.x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S--W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble
8193306 Methods for preparing polymeric reagents and compositions of polymeric reagents June 5, 2012
Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
8182801 Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid May 22, 2012
A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention provides water-soluble
8106131 Hydrolytically stable maleimide-terminated polymers January 31, 2012
The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
8084572 Segmented polymers and their conjugates December 27, 2011
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation t
8076412 Water-soluble polymer alkanals December 13, 2011
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and
8067505 Method of preparing carboxylic acid functionalized polymers November 29, 2011
Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C.dbd.0)OR', wherein R'
8058385 Method for preparing conjugates using polymer maleimides November 15, 2011
Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.
8039579 Intermediates useful in the preparation of maleimide functionalized polymers October 18, 2011
Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for prep
8003742 Polymer derivatives with proximal reactive groups August 23, 2011
An activated, substantially water-soluble polyoxazoline is provided having a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups.
7994272 Maleamic acid polymer derivatives and their bioconjugates August 9, 2011
The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.
7977427 Method involving 1-benzotriazolyl carbonate esters of polymers July 12, 2011
The invention provides a method comprising the steps of (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate e
7947261 Conjugates formed from polymer derivatives having particular atom arrangements May 24, 2011
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Relate
7910661 Thiol-selective water-soluble polymer derivatives March 22, 2011
The present invention provides water-soluble, polymer derivatives having a thiol-selective terminus suitable for selective coupling to thiol groups, such as those contained in the cysteine residues of proteins.
7887789 Polymer derivatives having particular atom arrangements February 15, 2011
Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related
7872082 Method for preparing polymer maleimides January 18, 2011
Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the polymeric reagents, and conjugates prepared by polymeric reagents obtained by the described methods.
7851565 Stabilized polymeric thiol reagents December 14, 2010
Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y--S--W].sub.x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S--W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble
7838595 Water-soluble polymer alkanals November 23, 2010
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and
7834138 Segmented polymers and their conjugates November 16, 2010
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation t
7829074 Hydroxypatite-targeting poly(ethylene glycol) and related polymers November 9, 2010
Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first ter
7790835 Method of preparing maleimide functionalized polymers September 7, 2010
Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for prep
7767784 Methods for preparing polymeric reagents and compositions of polymeric reagents August 3, 2010
Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.
7723432 Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) May 25, 2010
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an org
7714088 Poly(ethylene glycol) derivatives with proximal reactive groups May 11, 2010
An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reacti
7659361 Maleamic acid polymer derivatives and their bioconjugates February 9, 2010
The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.
7642323 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation January 5, 2010
This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the invention, an intermediate
7608663 Method of preparing propionic acid-terminated polymers October 27, 2009
The invention provides methods for preparing polymers bearing a terminal propionic acid. The method involves first reacting a water soluble and non-peptidic polymer comprising at least one hydroxyl group with a tertiary alkyl acrylate in the presence of a catalyst to form a propionic
7569214 Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid August 4, 2009
A method is provided for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid or ester thereof. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid. In addition, the invention provides water-soluble
7544738 Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) June 9, 2009
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an org
7528202 Poly (ethylene glycol) derivatives with proximal reactive groups May 5, 2009
An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reacti
7511094 Water-soluble polymer alkanals March 31, 2009
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and
7432331 Hydrolytically stable maleimide-terminated polymers October 7, 2008
The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
7432330 Hydrolytically stable maleimide-terminated polymers October 7, 2008
The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors.
7378469 Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) May 27, 2008
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an org
7329721 Maleamic acid polymer derivatives and their bioconjugates February 12, 2008
The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents and their conjugates.
7223803 Polyethylene (glycol) derivatives with proximal reactive groups May 29, 2007
An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reacti
7208145 Polymeric reagents comprising a ketone or a related functional group April 24, 2007
Polymeric reagents comprising a polymer attached, either directly or through one or more atoms to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioketal are provided.
7157546 Water-soluble polymer alkanals January 2, 2007
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and
7101932 Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol) September 5, 2006
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an org
7053150 Segmented polymers and their conjugates May 30, 2006
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation t
7030278 Polyethylene(Glycol) derivatives with proximal reactive groups April 18, 2006
An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reacti
6864327 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation March 8, 2005
This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the invention, an intermediate
6774180 Synthesis of high molecular weight non-peptidic polymer derivatives August 10, 2004
High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the reaction steps can be accomplished on the more readily purified small molecule to avoid labo
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