| Patent Number |
Title Of Patent |
Date Issued |
| RE34069 |
Process for the preparation of oligonucleotides |
September 15, 1992 |
| The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound |
| 7285422 |
Systems and methods for preparing and analyzing low volume analyte array elements |
October 23, 2007 |
| The invention provides methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dispense a spot of fl |
| 6991903 |
Solid phase sequencing of double-stranded nucleic acids |
January 31, 2006 |
| Methods for detecting and sequencing of target double-stranded nucleic acid molecules, nucleic acid probes and arrays of probes useful in these methods, and kits and systems that contain these probes are provided. The methods involve hybridizing the nucleic acids or nucleic acids which |
| 6569385 |
Systems and methods for preparing and analyzing low volume analyte array elements |
May 27, 2003 |
| Serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface are provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. |
| 6436635 |
Solid phase sequencing of double-stranded nucleic acids |
August 20, 2002 |
| This invention relates to methods for detecting and sequencing of target double-stranded nucleic acid sequences, to nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids o |
| 6428955 |
DNA diagnostics based on mass spectrometry |
August 6, 2002 |
| The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal ab |
| 6303309 |
Method for dissociating biotin complexes |
October 16, 2001 |
| A method for dissociating a complex of a biotin compound and a biotin-binding compound, by contacting the complex with an amine, is disclosed. |
| 6225450 |
DNA sequencing by mass spectrometry |
May 1, 2001 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 6146854 |
Filtration processes, kits and devices for isolating plasmids |
November 14, 2000 |
| Processes, kits and preferred devices for rapidly isolating large numbers of plasmid DNAs from plasmid containing cells and for performing high throughput DNA sequencing are described. |
| 6140053 |
DNA sequencing by mass spectrometry via exonuclease degradation |
October 31, 2000 |
| The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally |
| 6074823 |
DNA sequencing by mass spectrometry via exonuclease degradation |
June 13, 2000 |
| The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally |
| 6024925 |
Systems and methods for preparing low volume analyte array elements |
February 15, 2000 |
| The invention provides, in one aspect, serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells |
| 6022688 |
Method for dissociating biotin complexes |
February 8, 2000 |
| A method for dissociating a complex of a biotin compound and a biotin-binding compound, by contacting the complex with an amine, is disclosed. |
| 5928906 |
Process for direct sequencing during template amplification |
July 27, 1999 |
| Processes and kits for simultaneously amplifying and sequencing nucleic acid molecules, and perfonning high throughput DNA sequencing are described. |
| 5900481 |
Bead linkers for immobilizing nucleic acids to solid supports |
May 4, 1999 |
| Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased |
| 5872003 |
DNA sequencing by mass spectrometry via exonuclease degradation |
February 16, 1999 |
| Methods for determining the sequence of nucleic acids by cleaving the nucleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the |
| 5851765 |
DNA sequencing by mass spectrometry via exonuclease degradation |
December 22, 1998 |
| Methods for determining the sequence of nucleic acids by cleaving the nucleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the |
| 5691141 |
DNA sequencing by mass spectrometry |
November 25, 1997 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 5622824 |
DNA sequencing by mass spectrometry via exonuclease degradation |
April 22, 1997 |
| Methods for determining the sequence of nucleic acids by cleaving the nueleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the |
| 5605798 |
DNA diagnostic based on mass spectrometry |
February 25, 1997 |
| The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose (e.g. prenatally or postnatally) a gene |
| 5547835 |
DNA sequencing by mass spectrometry |
August 20, 1996 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 5198540 |
Process for the preparation of oligonucleotides in solution |
March 30, 1993 |
| Process for the preparation of oligonucleotides by successive linking of individual or several nucleoside and/or nucleotide units in a homogeneous phase system using a bi-, tri- or tetra-functional carrier molecule of the general formula Sp(X).sub.n, wherein X is a reactive group which i |
