| Patent Number |
Title Of Patent |
Date Issued |
| 7622463 |
Dihydrodiazepines useful as inhibitors of protein kinases |
November 24, 2009 |
| The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The i |
| 7589214 |
Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
September 15, 2009 |
| The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, |
| 7553852 |
Caspase inhibitors and uses thereof |
June 30, 2009 |
| The present invention relates to compounds of formula I: ##STR00001## useful as inhibitors of caspases. The present invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for preparing the compounds, and methods of using the compounds an |
| 7531536 |
Pyrazole compounds useful as protein kinase inhibitors |
May 12, 2009 |
| This invention describes novel pyrazole compounds of formula IIIa: ##STR00001## wherein R.sup.1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R.sup.x, R.sup.y, R.sup.2; and R. |
| 7361492 |
Crystal structure of aurora-2 protein and binding pockets thereof |
April 22, 2008 |
| The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encode |
| 7276502 |
Thiazoles useful as inhibitors of protein kinases |
October 2, 2007 |
| The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. |
| 7179826 |
Compositions useful as inhibitors of protein kinases |
February 20, 2007 |
| The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. |
| 7098330 |
Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors |
August 29, 2006 |
| This invention describes novel pyrazole compounds of formula III: ##STR00001## wherein Ring D is a 5 7 membered monocyclic ring or 8 10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R.sup.x and R.sup.y are taken together with their intervening a |
| 7091343 |
Compositions useful as inhibitors of protein kinases |
August 15, 2006 |
| The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. |
| 7053057 |
Caspase inhibitors and uses thereof |
May 30, 2006 |
| This invention provides caspase inhibitors having the formula: ##STR00001## wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R.sup.1 is hydrogen, CHN.sub.2, R, or --CH.sub.2Y; R is an optionally substituted group selected fr |
| 7041687 |
Indazole compounds useful as protein kinase inhibitors |
May 9, 2006 |
| The present invention provides compounds of formula I: ##STR00001## or a pharmaceutically acceptable derivative thereof, wherein R.sup.1, R.sup.2, V.sup.1, V.sup.2, and V.sup.3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibito |
| 7008948 |
Fused pyrimidyl pyrazole compounds useful as protein kinase inhibitors |
March 7, 2006 |
| This invention describes novel pyrazole compounds of formula IV: ##STR00001## wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R.sup.x and R.sup.y are independently selected from T-R.sup.3, o |
| 6989385 |
Pyrazole compounds useful as protein kinase inhibitors |
January 24, 2006 |
| This invention describes novel pyrazole compounds of formula IIc: ##STR00001## wherein R.sup.1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R.sup.x and R.sup.y are taken toget |
| 6846928 |
Compositions useful as inhibitors of protein kinases |
January 25, 2005 |
| The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. |
| 6800619 |
Caspase inhibitors and uses thereof |
October 5, 2004 |
| Described herein are compounds that are useful as caspase inhibitors having the formula: ##STR1##wherein Ring A is an optionally substituted piperidine, tetrahydroquinoline or tetrahydroisoquinoline ring; R.sup.1 is hydrogen, CN, CHN.sub.2, R, or CH.sub.2 Y; R is an optionally substi |
| 6664247 |
Pyrazole compounds useful as protein kinase inhibitors |
December 16, 2003 |
| This invention describes novel pyrazole compounds of formula IIIa: ##STR1##wherein R.sup.1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R.sup.x, R.sup.y, R.sup.2, and R.sup.2' are |
| 6653301 |
Pyrazole compounds useful as protein kinase inhibitors |
November 25, 2003 |
| This invention describes novel pyrazole compounds of formula IIa: ##STR1##wherein R.sup.1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R.sup.x and R.sup.y are taken together with |
| 6653300 |
Pyrazole compounds useful as protein kinase inhibitors |
November 25, 2003 |
| This invention describes novel pyrazole compounds of formula I': ##STR1##wherein Q' is --O--, --C(R.sup.6').sub.2 --, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3-cyclopropanediyl, and R.sup.1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic |
