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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Kempf; Dale J.
Address:
Libertyville, IL
No. of patents:
68
Patents:


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Patent Number Title Of Patent Date Issued
8232246 Anti-viral compounds July 31, 2012
Compounds capable of inhibiting replication of the hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
8193227 HIV protease inhibiting compounds June 5, 2012
A compound of the formula ##STR00001## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
8133892 Compounds that are useful for improving pharmacokinetics March 13, 2012
Novel compounds of formula 1 ##STR00001## or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
7968707 Retroviral protease inhibiting compounds June 28, 2011
A compound of the formula: ##STR00001## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
7951800 Anti-infective agents May 31, 2011
The present invention provides HCV polymerase inhibiting compounds having the formula (I): ##STR00001## where R.sup.1 is cyclobutyl-N(R.sub.a)--, n is 1, 2, 3 or 4, and at least one R.sup.5 is R.sub.aSO.sub.2N(R.sub.j)alkyl-. In a non-limiting example, a compound of the present inv
7915411 Anti-viral compounds March 29, 2011
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, pro
7910595 Anti-viral compounds March 22, 2011
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, pro
7902203 Anti-infective agents March 8, 2011
The present invention provides an HCV polymerase inhibiting compound having the formula (I) ##STR00001## and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase,
7834043 HIV protease inhibiting compounds November 16, 2010
A compound of the formula ##STR00001## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
7786153 Compounds that are useful for improving pharmacokinetics August 31, 2010
Novel compounds of formula 1 ##STR00001## or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
7763731 Anti-viral compounds July 27, 2010
Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, pro
7718633 Prodrugs of HIV protease inhibitors May 18, 2010
A compound of the formula ##STR00001## is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.
7696226 HIV protease inhibiting compounds April 13, 2010
A compound of the formula ##STR00001## is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
7662958 Anti-infective agents February 16, 2010
The present invention provides HCV polymerase inhibiting compounds having the formula (I): ##STR00001## where R.sup.1 is cyclobutyl-N(R.sub.a)--, n is 1, 2, 3 or 4, and at least one R.sup.5 is R.sub.aSO.sub.2N(R.sub.j)alkyl-. In a non-limiting example, a compound of the present inven
7547678 Method for treating a disease, disorder or adverse effect caused by an elevated serum concentrat June 16, 2009
The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir.
7320961 Method for treating a disease, disorder or adverse effect caused by an elevated serum concentrat January 22, 2008
The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir.
6831096 Inhibitors of neuraminidases December 14, 2004
Disclosed are compounds of the formula: ##STR1##which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a
6703403 Method for improving pharmacokinetics March 9, 2004
A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
6667404 Retroviral protease inhibiting compounds December 23, 2003
A retroviral protease inhibiting compound of the formula: ##STR1##is disclosed.
6593314 Neuraminidase inhibitors July 15, 2003
The present invention provides compounds of formula Ia and Ib ##STR1##or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulatio
6531610 Retroviral protease inhibiting compounds March 11, 2003
A retroviral protease inhibiting compound of the formula: ##STR1##is disclosed.
6518305 Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases February 11, 2003
Disclosed are compounds of the formula: ##STR1##which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a
6472529 Retroviral protease inhibiting compounds October 29, 2002
A compound of the formula: ##STR1##is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
6455571 Inhibitors of neuraminidases September 24, 2002
Disclosed are compounds of the formula: ##STR1##which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a
6313296 Retroviral protease inhibiting compounds November 6, 2001
A compound of the formula: ##STR1##is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
6284767 Retroviral protease inhibiting compounds September 4, 2001
A compound of the formula: ##STR1##is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
6251906 Retroviral protease inhibiting compounds June 26, 2001
The present invention discloses novel compounds, compositions, and methods for inhibiting retroviral proteases and in particular for inhibiting human immunodeficiency virus (HIV) protease. The present invention also relates to compositions and methods for treating a retroviral infection
6150530 Retroviral protease inhibiting compounds November 21, 2000
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
6037157 Method for improving pharmacokinetics March 14, 2000
A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
6017928 Retroviral protease inhibiting compounds January 25, 2000
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5990135 Retroviral protease inhibiting compounds November 23, 1999
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5905068 Retroviral protease inhibiting compounds May 18, 1999
A compound of the formula: ##STR1## is disclosed as a retroviral protease inhibitor compound. Also disclosed are methods and compositions for inhibiting an HIV infection.
5892052 Process for making retroviral protease inhibiting compounds April 6, 1999
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5886036 Retroviral protease inhibiting compounds March 23, 1999
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5846987 Retroviral protease inhibiting compounds December 8, 1998
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5696270 Intermediate for making retroviral protease inhibiting compounds December 9, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5679797 Retroviral protease inhibiting compounds October 21, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5674882 Retroviral protease inhibiting compounds October 7, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5659045 Retroviral protease inhibiting compounds August 19, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5659044 Retroviral protease inhibiting compounds August 19, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5648497 Retroviral protease inhibiting compounds July 15, 1997
A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral
5635523 Retroviral protease inhibiting compounds June 3, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5631376 Retroviral protease inhibiting compounds May 20, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5625072 Retroviral protease inhibiting compounds April 29, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5621109 Retroviral protease inhibiting compounds April 15, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed wherein the terms R.sub.1, R.sub.2, R.sub.5, R.sub.6, Y, Y', m and n are herein defined.
5616720 Retroviral protease inhibiting compounds April 1, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5616714 Retroviral protease inhibiting compounds April 1, 1997
A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral
5608072 Retroviral protease inhibiting compounds March 4, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5597928 Retroviral protease inhibiting compounds January 28, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5597927 Retroviral protease inhibiting compounds January 28, 1997
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
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