| Patent Number |
Title Of Patent |
Date Issued |
| 6506929 |
Process to manufacture simvastatin and intermediates |
January 14, 2003 |
| A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure. |
| 6468977 |
Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
October 22, 2002 |
| Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by inhibition of human rhinovirus |
| 6245903 |
Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof |
June 12, 2001 |
| A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of di |
| 6162791 |
Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes |
December 19, 2000 |
| Novel 1,2,4-thiadiazole compounds are provided, which are effective as inhibitors of cysteine activity-dependent enzymes and in particular of cysteine proteases. The compounds are useful in treating acne by inhibition of transglutaminase, common cold by inhibition of human rhinovirus |
| 6114537 |
Process for scavenging thiols |
September 5, 2000 |
| Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologica |
| 6063933 |
Process for the manufacture of bis-triazole compounds and intermediates useful in the manufactur |
May 16, 2000 |
| The present invention relates to a process to prepare a compound of formula (I) wherein Y and Z can be identical or different and represent a halogene. The bis-triazole compounds of formula (I) and intermediates have antifungal activity. |
| 6060472 |
Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+ atpase |
May 9, 2000 |
| Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H.sup.+ /K.sup.+ -ATPase. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadiazole corresponding to the general formula (I): ##ST |
| 5914401 |
Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof |
June 22, 1999 |
| Novel process for the preparation of quinolone carboxylic acid derivatives of general formula I, and intermediates thereof as illustrated in Scheme 1 wherein the key intermediate is a compound of formula IX. ##STR1## |
| 5900485 |
Methods for the manufacture of neofazodone |
May 4, 1999 |
| Process for the manufacture of triazolone compounds and in particular nefazodone and intermediates useful in the manufacture thereof. |
| 5847118 |
Methods for the manufacture of amorphous cefuroxime axetil |
December 8, 1998 |
| A process for preparing pure amorphous cefuroxime axetil comprising the steps of dissolving crystalline cefuroxime axetil in a highly polar organic solvent and adding the resulting solution to water, or alternatively, dissolving crystalline cefuroxime axetil in a highly polar solvent |
| 5723618 |
1,4-dihydropyridines, N-substituted bicyclic 4-hydropyridines, and bicyclic N-substituted 4,5-di |
March 3, 1998 |
| The invention relates to a novel process to prepare 1,4-dihydropyridines and in particular amlopidine and in novel intermediates obtained during the synthesis of the 1,4-dihydropyridines which have potential activity as antihypertensive agents. |
| 5677302 |
Thiadiazole compounds useful as proton pump inhibitors |
October 14, 1997 |
| Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H.sup.+ /K.sup.+ -ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5-.alpha.]benzimidazole and 3-substituted |
