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Inventor:
Kanda; Yutaka
Address:
Machida, JP
No. of patents:
29
Patents:












Patent Number Title Of Patent Date Issued
8158760 Glycoengineered, recombinant antibody April 17, 2012
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
8067232 Antibody composition-producing cell with inactivated A-1,6-fusocyltransferase November 29, 2011
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
8039595 Glycoengineered, recombinant antibody to CCR-4 with reduced fucosylation October 18, 2011
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7846725 Antibody composition-producing cell in which enzyme expression is inhibited by RNAi December 7, 2010
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7776849 Benzenoid ansamycin derivative August 17, 2010
The present invention provides a benzenoid ansamycin derivative represented by Formula (I) ##STR00001## (wherein R.sup.1 and R.sup.2 each represent a hydrogen atom or are combined together to form a bond, R.sup.8 represents a bond or an oxygen atom, R.sup.11 represents hydroxy, subs
7763246 Method of modulating the activity of functional immune molecules to platelet-derived growth fact July 27, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7749753 Cells in which activity of the protein involved in transportation of GDP-fucose is reduced or lo July 6, 2010
A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plan
7741442 Antibody composition exhibiting increased cellular cytotoxicity due to glycosylation June 22, 2010
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7737325 Antibody composition-producing cell June 15, 2010
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-modulated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7718175 Method of modulating the activity of functional immune molecules to interleukin-5 receptor prote May 18, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7708997 Method of modulating the activity of functional immune molecules May 4, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7708992 Methods for producing antibody compositions with increased ADCC May 4, 2010
The invention relates to methods for modulating the antibody-dependent cellular cytotoxicity of an IgG antibody composition.
7691810 Method of producing recombinant antithrombin III composition April 6, 2010
The present invention provides a process for producing an antithrombin III composition comprising an antithrombin III molecule having complex type N-glycoside-linked sugar chains, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound t
7687061 Method of modulating the activity of functional immune molecules to Her-2 March 30, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7682611 Method of modulating the activity of functional immune molecules to CXCR4 protein March 23, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7682610 Method of modulating the activity of functional immune molecules March 23, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7655228 Method of modulating the activity of functional immune molecules to GM2 February 2, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7651688 Method of modulating the activity of functional immune molecules to CD52 January 26, 2010
The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule ha
7538241 Hsp90 family protein inhibitors May 26, 2009
##STR00001## (wherein n is an integer of 0 to 10; R.sup.1 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocy
7425446 Antibody composition-producing cell September 16, 2008
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7393683 Mammalian host cell modified by RNAi to inhibit .alpha. 1,6-fucosyltransferase July 1, 2008
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
7214775 Method of modulating the activity of functional immune molecules May 8, 2007
The invention relates to a method for controlling the activity of an immunologically functional molecules, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule h
6946292 Cells producing antibody compositions with increased antibody dependent cytotoxic activity September 20, 2005
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the
6815449 LK6-A derivatives November 9, 2004
Compounds having immunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. are represented by formula I: ##STR1##and pharmaceutically acceptable salts thereof.
6407087 UCF116 derivatives June 18, 2002
UCF116 derivatives represented by formula (I): ##STR1##whereinQ represents ##STR2##and R represents hydrogen, C(.dbd.O)R.sup.1a (wherein R.sup.1a represents methyl, ethyl, propyl, isopropyl, 2,2-dimethylpropyl, pentyl, alkyl having 6 to 10 carbon atoms, 1-propenyl, isopropenyl, 2-met
5925641 Farnesyltransferase inhibitor July 20, 1999
The present invention relates to a farnesyltransferase inhibitor and an antitumor agent comprising, as an active ingredient, a piperazinedione derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent lower alkyl, lower alkoxyalkyl, subst
5728830 Farnesyltransferase inhibitor March 17, 1998
The present invention relates to a farnesyltransferase inhibitor and an antitumor agent comprising, as an active ingredient, a piperazinedione derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent lower alkyl, lower alkoxyalkyl, subst
5334611 6-ethyl mitomycin derivatives August 2, 1994
Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.
5256685 Mitomycin derivatives October 26, 1993
Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.










 
 
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