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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Jolidon; Synese
Address:
Blauen, CH
No. of patents:
42
Patents:












Patent Number Title Of Patent Date Issued
8586581 Ethynyl compounds useful for treatment of CNS disorders November 19, 2013
The present invention relates to ethynyl compounds of formula ##STR00001## wherein X, Y, Z, and R.sup.4 are as defined herein or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoi
8288403 Heterocyclic gamma secretase modulators October 16, 2012
The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome which comprise administering a therapeutically
8188139 Heterocyclic-substituted phenyl methanones May 29, 2012
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, and are defined in the specification and to pharmaceutically acceptable acid addition salts thereof.
7964645 Di-aromatic substituted amides as inhibitors for GlyT-1 June 21, 2011
The present invention relates to compounds of formula I ##STR00001## wherein ##STR00002## R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X, and n are as defined herein and the dotted line denotes an optional bond and pharmaceutically acceptable acid addition salts thereof. The compo
7951836 Substituted phenyl methanone derivatives May 31, 2011
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, X, n, and m are as defined herein and to pharmaceutically acceptable acid addition salts thereof, to pharmaceutical compositions containing them, and to methods for treating neuro
7923450 Modulators for amyloid beta April 12, 2011
The invention relates to compounds of formula ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used for the treatment of Alzheimer's disease, cerebral amyloid angi
7910740 Modulators of amyloid beta March 22, 2011
The invention relates to compounds of formula ##STR00001## wherein hetaryl I, hetaryl II, and R.sup.1 are as described herein. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposit
7790763 Substituted phenyl methanone derivatives September 7, 2010
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, n, and m, are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (G
7605163 Benzoyl-piperazine derivatives October 20, 2009
The invention relates to compounds of formula ##STR00001## wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, sch
7595314 Benzoyl-piperazine derivatives September 29, 2009
A compound of formula ##STR00001## wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as
7589089 Inhibitors for GlyT-1 September 15, 2009
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and X are as defined herein or to pharmaceutically acceptable acid addition salts thereof, with the exception of 4-methoxy-N-[2-oxo-2-(phenylamino)ethyl]-N-phenyl-benzamide,
7557114 Heterocyclic-substituted phenyl methanones July 7, 2009
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1 and R.sup.2 are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Compounds of the invention are GlyT-1 inhibitors and are useful for the treatment of CNS d
7553862 4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones June 30, 2009
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined herein and to pharmaceutically acceptable acid addition salts thereof. Compounds of formula I or their tautomeric forms are good inhibitors of the glycine
7485637 Benzoyl-tetrahydropiperidine derivatives February 3, 2009
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, and Ar; are as defined in the specification. The invention also provides pharmaceutically acceptable acid addition salts thereof and methods for the treatment of neurological and neuropsych
7462617 Substituted acylpiperazine derivatives December 9, 2008
The invention relates to compounds of formula ##STR00001## wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof.The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative dis
7442710 Substituted phenyl methanones October 28, 2008
The present invention relates to compounds of general formula IA or IB ##STR00001## wherein X.sup.1 and X.sup.2 are each independently N or C--R'' and R.sup.1, R.sup.2,R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as defined in the specification and to pharmaceutically acceptable acid
7429585 Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups September 30, 2008
The present invention relates to compounds of the general formula IC ##STR00001## wherein R.sup.2, R', R'', R.sup.3, R.sup.6, X.sup.1 and X.sup.1' are as defined herein and pharmaceutically active acid addition salts thereof. Compounds of the invention are useful for the treatment of
7427612 Benzoyl-piperazine derivatives September 23, 2008
A compound of formula ##STR00001## wherein the substituents are as described in the specification for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as
7375226 Bi- and tricyclic substituted phenyl methanones May 20, 2008
The present invention relates to compounds of formula IA ##STR00001## whereinR.sup.1, R.sup.2, R.sup.3, and n are as defined in the specification, and to pharmaceutically active acid addition salts thereof. The compounds of the invention are useful in the treatment of neurological an
7319099 Benzoyl-piperazine derivatives January 15, 2008
The invention relates to compounds of formula ##STR00001## wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, sch
7265126 Diaza-spiropiperidine derivatives September 4, 2007
The present invention relates to compounds of formula ##STR00001## wherein A-B, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein; and to pharmaceutically acceptable salts thereof.The compounds of formula I may be used in the treatment of neurological and neuropsychiatr
7253318 Benzyloxy derivatives as MAOB inhibitors August 7, 2007
The invention relates to compounds of the formula ##STR00001## and their pharmaceutically acceptable salts wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase .beta. inhibitors and are us
7241761 Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups July 10, 2007
The present invention relates to compounds of the general formula I ##STR00001## wherein R.sup.1 is the group ##STR00002## and R.sup.2, R', R'', R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X.sup.1, X.sup.1', X.sup.2, and N are as defined in the specification. Compounds of the inve
7235581 4-pyrrolidino-phenyl-benzyl ether derivatives June 26, 2007
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhi
7220744 Monocyclic substituted phenyl methanones May 22, 2007
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, X.sup.1, and X.sup.2 are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Such compounds are inhibitors of the glycine transporter 1 (GlyT-1)
7173133 Diaza-spiropiperidine derivatives February 6, 2007
The present invention relates to compounds of formula ##STR00001## wherein A-B is --CH.sub.2--CH.sub.2--, --CH.sub.2--O-- or --O--CH.sub.2--; X is hydrogen or hydroxy; R.sup.1 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lo
7173023 Bicyclic compounds February 6, 2007
The present invention relates to novel benzazepine derivatives of the following formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5, X, X', Y and Y' are as defined in the description and claims, processes for their preparation, pharmaceutical compositions co
7151111 4-pyrrolidino-phenyl-benzyl ether derivatives December 19, 2006
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibit
7122562 4-pyrrolidino-phenyl-benzyl ether derivatives October 17, 2006
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidas
7053245 N-acylamino benzyl ether derivatives May 30, 2006
This invention relates to N-acylamino aryl derivatives of the formula ##STR00001## where R.sup.1, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R, and n are as defined herein and where X is --CHRO, --OCHR--, --CH.sub.2S--, --SCH.sub.2-
7037935 4-Pyrrolidino-phenyl-benzyl ether derivatives May 2, 2006
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidas
6951884 Fluorobenzamides and uses thereof October 4, 2005
The invention relates to fluorobenzamide derivatives of the formula ##STR1##wherein R.sup.1, R.sup.2, R.sup.3 R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined herein. =,The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the
6900354 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives May 31, 2005
The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula ##STR1##wherein A is selected from ##STR2##R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.21, R.sup.22, R.sup.23, R.sup.24,
6846832 2,3-dihydro-isoindol-1-one derivatives January 25, 2005
2,3-Dihydro-isoindol-1-one derivatives, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them, for the prevention and treatment of diseases which are mediated by monoamine oxidase B.
6762320 N-acylamino benzyl ether derivatives July 13, 2004
This invention relates to N-acylamino aryl derivatives of the formula ##STR1##where R.sup.1, R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.3, R.sup.4, R.sup.5 R.sup.6, R.sup.7, R.sup.8, R, and n are as defined herein and where X is --CHRO, --OCHR--, --CH.sub.2 S--, --SCH.sub.2 --, -
6603012 RAR selective retinoid agonists August 5, 2003
New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are useful as RAR selective retinoid agonists. Furthermore, such retinoic acid receptor agonists, pa
6441177 Tertiary amines August 27, 2002
Tertiary amines of the formula ##STR1##wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.
6399641 2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonis June 4, 2002
The present invention is a series of 2H-tetrazole-5-yl-amide derivatives showing activity as ligands of metabotropic glutamate receptors.
6114330 Substituted 2,4-diaminopyrimidines September 5, 2000
The invention is concerned with compounds of formula ##STR1## wherein R.sup.1 is lower-alkoxy, R.sup.2 is hydroxy or lower-alkoxy, R.sup.3 is hydrogen, cyano, alkyl, alkenyl, cycloalkyl, aryl, heterocycyl, aryl-Q-alkyl, or a group of the formula --CR.sup.4 R.sup.4 'COR.sup.5 --,
6034275 Tertiary amines March 7, 2000
Tertiary amines of the formula ##STR1## wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, L, M, p, T, and Q are as defined herein, have antimycotic and cholesterol-lowering activity.
5763450 Substituted benzyl pyrimidines June 9, 1998
Compounds of the formula: ##STR1## in which R.sup.1 is lower alkoxy, R.sup.2 is bromine or lower alkoxy, and R.sup.3 is aryl, heteroaryl or a group --Q--R.sup.30, wherein Q is ethylene, vinylene or ethynylene and R.sup.30 is aryl, heteroaryl, lower alkoxycarbonyl or carbamoyl;hyd
5596002 Method of treating chloroquine-resistant malaria with aminoquinoline derivatives January 21, 1997
Novel aminoquinoline derivatives of the general formula ##STR1## are described. Also described are methods for the treatment of malaria pathogens, particularly chloroquine-resistance malaria pathogens with compounds of formula I or the pharmaceutically acceptable salts and hydrol










 
 
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