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Inventor:
Imanaka; Hiroshi
Address:
Osaka, JP
No. of patents:
28
Patents:












Patent Number Title Of Patent Date Issued
RE32992 Peptide process for preparation thereof and use thereof July 18, 1989
The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R
4863926 Nitro aliphatic compounds, process for preparation thereof and use thereof September 5, 1989
New nitro aliphatic compounds useful as antithrombotic and antihypertensing agents are disclosed.
4801580 Peptide, process for preparation thereof and use thereof January 31, 1989
The invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R.sup.1 is hydrogen,R.sub.b.sup.1 is methyl,R.sup.2 is carboxy, carboxymethylcarbamoyl, 1-carboxyethylcarbamoyl or ethoxycarbonylmethylcarbamoyl,R.sup.q is carboxy or 3-t-butoxycarb
4797417 Furanone derivatives, process for preparation thereof and use thereof January 10, 1989
The invention relates to novel furanone derivatives, having an aldose reductase-inhibitory activity, of the formula ##STR1## wherein A is a lower alkylene group,R.sup.1 is a carboxy, hydroxy, protected hydroxy or lower alkoxycarbonyl group,R.sup.2 is a hydrogen or halogen atom or a h
4782088 Nitro aliphatic compounds and use thereof November 1, 1988
The invention relates to compounds of antihypertensive and antithrombotic activity of the formula or its pharmaceutically acceptable salt: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, or lower alkoxyphenyl,R.sup.2 is hydrogen or lower alkyl,R.sup.4 is lower alkyl,R.sup.6 is hydroge
4778804 Nitro aliphatic compounds, process for preparation thereof and use thereof October 18, 1988
New nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.
4767768 Nitro aliphatic compounds, process for preparation thereof and use thereof August 30, 1988
New Nitro aliphatic compounds and their pharmaceutically acceptable salts are disclosed.
4749691 Peptide, process for preparation thereof and use thereof June 7, 1988
The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is hydroxyalkanoyl,R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or d
4725582 Peptide, process for preparation thereof and use thereof February 16, 1988
The invention concerns peptides, having the pharmaceutical property of enhancing the immune response, having the structure: ##STR1## wherein R.sup.1 is alkanoyl,R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl,R.sup.2 is hydrogen, carboxy
4680178 Antitumor agent comprising FR-900216 July 14, 1987
The invention relates to a pharmaceutical composition for treating lymphocytic leukemia, melanoma or mammary carcinoma comprising an effective amount of FR-900216.
4666890 Peptide, process for preparation thereof and use thereof May 19, 1987
The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is alkanoyl;R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carbo
4585789 New furanone derivatives, process for preparation thereof and use thereof April 29, 1986
Described are compounds of the formula: ##STR1## Wherein A is a lower alkylene group;R.sup.1 is a carboxy, hydroxy, lower alkoxycarbonyl, lower alkoxycarbonylamino, phenyl(lower)alkyloxy, benzoyloxy or lower alkanoyloxy group;R.sup.2 is a hydrogen or halogen atom or a halo(lower)alky
4539155 New peptide, process for preparation thereof and use thereof September 3, 1985
The invention relates to compounds and salts of compounds which are diaminopimelyl peptides, N-acetoxypropionyl or N-t-butoxycarbonyl-amino-acid - (.alpha.-OBzl) glutamic acid peptides or N-acylated derivatives of (.alpha.-OBzl) glytamic acid or of (.alpha.-OBzl) aminoadipic acid.The
4530845 1,4-Napthoquinone derivatives and use thereof July 23, 1985
1,4-naphthoquinone derivatives represented by the following general formula: ##STR1## (wherein R.sup.1 represents a hydrogen atom, a hydroxy group, a lower alkoxy group or an arylthio group, R.sup.2 represents a carboxy group, an esterified carboxy group or an amidated carboxy gr
4517299 Acetylesterases May 14, 1985
New acetylesterases are prepared from Aureobasidium pullulans IFO 4466 which are capable of hydrolyzing cephalosporin C to deacetylcephalosporin C.
4504584 Cultures of novel strains of Streptomyces March 12, 1985
The invention relates to a biologically pure culture of new strains of the microorganism Streptomyces which are capable upon fermentation of producing a peptide of pharmacological activity.
4479942 Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutica October 30, 1984
This invention relates to tetrahydrofuran-carboxylic acid derivatives, of antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,R.sup.2 is amino or acylamino andR.sup.3 is carboxy or a protected carboxy groupor a pharmaceutically acceptable
4458078 Oxazole derivatives July 3, 1984
The invention relates to novel intermediates for the preparation of peptides of pharmacological activity, said intermediates being of the formulas: ##STR1## wherein R.sub.2.sup.r is amino protective group andY is hydrogen or amino protective group; and : ##STR2##
4414328 Process for the preparation of deacetylcephalosporin C November 8, 1983
Deacetylcephalosporin C is converted to cephalosporin C by contact with an acetylesterase produced by Aureobasidium pullanans strain 1F0 4466.
4414226 1,4-Naphtoquinone derivatives and their use in treating coccidiosis November 8, 1983
1,4-naphthoquinone derivatives represented by the following general formula: ##STR1## (wherein R.sup.1 represents a hydrogen atom, a hydroxy group, a lower alkoxy group or an arylthio group, R.sup.2 represents a carboxy group, an esterified carboxy group or an amidated carboxy gr
4330529 Antibacterial composition May 18, 1982
The present invention relates to an antibacterial composition comprising a phosphonic acid derivative of the formula: ##STR1## wherein R is lower alkanoyl andn is an integer of 2 to 5 or its saltand an antibiotic selected from a B-lactam antibiotic, aminoglycoside antibiotic and thei
4313935 Antibiotic FR-900129 substance, a process for the preparation thereof and pharmaceutical composi February 2, 1982
Prodn. of FR-900129 comprises culturing a Streptomyces n. 4012 category which is analogous to Streptomyces misakiensis and Steptomyces aburaviensis, i.e. Streptomyces avellaneus No. 4012, at 25.degree. C. to 30.degree. C. during 50 to 100 hours in a culture medium which consists of a
4311640 Peptide, process for preparation thereof and use thereof January 19, 1982
The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R
4297096 Alkyl, alkenyl, and aryl substituted triazene compounds, their salts and production thereof October 27, 1981
A new triazene compound of the formula:wherein R is alkyl, alkenyl or aryl and its pharmaceutically acceptable salts thereof. The production and use of such compounds are also disclosed. The compounds are useful as smooth muscle relaxants and hypotensives.
4268503 Antibacterial composition May 19, 1981
This invention relates to an antibacterial composition comprising a phosphonic acid and an antibiotic.
4210635 Antibacterial composition July 1, 1980
The present invention relates to an antibacterial composition and to a method for the treatment of infectious diseases caused by pathogenic bacteria employing a phosphonic acid derivative and an antibiotic.
4146536 Nocardicin E and F, and process for production thereof March 27, 1979
This invention relates to new compounds having antibacterial activity.More particularly, it relates to new antibiotics, Nocardicin E and F and to a process for production of the same by fermentation.
4110166 Process for the production of nocardicin A August 29, 1978
Nocardicin A is produced by culturing a Nocardicin A producing microorganism in a medium containing at least one of shikimic acid, a hydroxy phenyl carboxylic acid, glycine, alanine, serine, homoserine, .alpha.aminobutyric acid, .alpha., .beta.-diaminoproprionic acid and their ester,










 
 
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