| Patent Number |
Title Of Patent |
Date Issued |
| 7498460 |
Isophthalic acid derivatives |
March 3, 2009 |
| The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders. |
| 7135486 |
Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof |
November 14, 2006 |
| This application relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, pharmaceutical compositions containing th |
| 7129255 |
Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective lig |
October 31, 2006 |
| This application relates to compounds of the formula ##STR00001## wherein the groups R.sup.1 R.sup.6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders. |
| 7109218 |
Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same |
September 19, 2006 |
| Compounds of the formula (I) ##STR00001## a process for their preparation and their use as medicaments are described. |
| 7078417 |
Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activit |
July 18, 2006 |
| This application relates to pyridine derivatives having the general structure ##STR00001## in which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmacutical composition containing such compounds, and a metho |
| 7045631 |
Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-se |
May 16, 2006 |
| Compounds of the formula (I) ##STR00001## a process for preparing them, and their use as medicaments are described. |
| 6831197 |
Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives |
December 14, 2004 |
| The present application relates to a plurality of novel processes for preparing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives, to novel intermediates for their preparation, and to processes for preparing these intermediates. |
| 6756512 |
Method for producing 2-alkyl-3-chlorophenols |
June 29, 2004 |
| The invention relates to a novel process for preparing 2-alkyl-3-chlorophenols. |
| 6734304 |
Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives |
May 11, 2004 |
| The invention relates to a novel process for preparing known asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives. |
| 6700017 |
Methods for producing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamide derivatives |
March 2, 2004 |
| The present invention provides processes for preparing 2-(2-hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamides, to intermediates for this preparation, and to processes for preparing those intermediates. |
| 6660872 |
Method of producing methoxyimino acetic amide |
December 9, 2003 |
| The present invention relates to novel processes for preparing methoxyimino-acetamides. |
| 6603025 |
Method of production of benzofuranone oximes |
August 5, 2003 |
| The present invention relates to a novel process for preparing known benzofuranone oximes, and to a novel process for preparing known benzofuranyl alkanoates which are used as intermediates in the synthesis sequence. |
| 6462205 |
Method of preparing benzofurandione oxime derivatives |
October 8, 2002 |
| The present invention relates to a novel process for preparing benzofurandioneoxime derivatives by reacting benzofurandioneoxime derivatives with acids. |
| 6277833 |
Substituted triols |
August 21, 2001 |
| Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments. |
| 5874438 |
2,2'-bridged bis-2,4-diaminoquinazolines |
February 23, 1999 |
| The present invention relates to 2,2'-bridged bis-2,4-diaminoquinazolines of the general formula (I): ##STR1## in which the indicated substituents are as defined in the description. The invention also provides processes for the preparation of the compounds of the formula (I), the |
| 5863930 |
Trisubstituted biphenyls |
January 26, 1999 |
| Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments. |
| 5861385 |
Substituted triols |
January 19, 1999 |
| Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments. |
| 5834481 |
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
November 10, 1998 |
| Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicame |
| 5776964 |
Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments |
July 7, 1998 |
| The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be |
| 5712296 |
Substituted pyridines and 2-oxo-1,2-dihydropyridines |
January 27, 1998 |
| Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medic |
| 5708003 |
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
January 13, 1998 |
| Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicam |
| 5627285 |
Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives |
May 6, 1997 |
| Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in |
| 5599823 |
Substituted biphenylpyridones |
February 4, 1997 |
| Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. |
| 5596006 |
Trisubstituted biphenyls |
January 21, 1997 |
| Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,R.sub.2 represents straight-chain or branched C.sub.1 -C.sub.8 -alkyl,R.sub.3 represents h |
| 5594010 |
Substituted monopyridylmethyl derivatives |
January 14, 1997 |
| The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis. |
| 5576342 |
Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives |
November 19, 1996 |
| Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments. |
| 5530016 |
Substituted 2,4-imidazolidinediones |
June 25, 1996 |
| Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid deri |
| 5527809 |
Substituted imidazo[4,5-b]pyridines and benzimidazoles |
June 18, 1996 |
| Substituted imidazo[4,5-b]pyridines and benzimidazoles are prepared by reacting imidazo[4,5-b]pyridines or benzimidazoles with appropriately substituted benzyl halides. The substituted imidazo[4,5-b]pyridines or benzimidazoles can be employed as active compounds in medicaments, in pa |
| 5521206 |
Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments |
May 28, 1996 |
| The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitro |
| 5508299 |
Imidazolyl-substituted cyclohexane derivatives |
April 16, 1996 |
| Imidazolyl-substituted cyclohexane derivatives are prepared by reacting appropriate cyclohexane derivatives with substituted imidazoles and subsequent variation of the substituents.The imidazolyl-substituted cyclohexane derivatives can be employed as active compounds in medicaments, in p |
| 5502057 |
Polysubstituted pyridines useful for treating lipoproteinanaemia and arteriosclerosis |
March 26, 1996 |
| For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substitut |
| 5492923 |
Substituted pyridines and 2-oxo-1,2-dihydropyridines |
February 20, 1996 |
| Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medic |
| 5478836 |
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
December 26, 1995 |
| Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicam |
| 5475016 |
Sulphonylbenzyl-substituted imidazolypropenoic acid derivatives |
December 12, 1995 |
| Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in |
| 5470982 |
Disubstituted pyridines |
November 28, 1995 |
| For the treatment of lipoproteinaemia and arteriosclerosis, the new disubstituted pyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen, cycloalkyl, or optionally substitut |
| 5459156 |
Imidazolyl-substituted phenylacetic acid prolinamides |
October 17, 1995 |
| Imidazolyl-substituted phenylacetic acid prolinamides are prepared by reacting corresponding imidazolyl-substituted phenylacetic acids with prolines. The imidazolyl-substituted phenylacetic acid prolinamides can be used as active compounds in medicaments, preferably for the treatment of |
| 5418243 |
Substituted 4-phenyl-pyridones and 4-phenyl-3-alkoxypyridines |
May 23, 1995 |
| Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines are prepared by reducing corresponding 4-phenyl-pyridone and 4-phenyl-2-alkoxypyridine derivatives. The substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines can be employed as active compounds in medicaments, in p |
| 5414008 |
Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives |
May 9, 1995 |
| Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives are prepared by reacting appropriate benzyl compounds with imidazoles and optionally varying the substituents. The imidazolyl-substituted phenylpropionic and cinnamic acid derivatives can be used as active compounds |
| 5414003 |
Pyridinylmethyl-substituted pyridines and pyridones |
May 9, 1995 |
| Pyridinylmethyl-substituted pyridines and pyridones are prepared by reacting pyridine- or pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substances according to the invention can be used as active compounds in medicaments, in particular for the treatme |
| 5409910 |
Substituted pyridines |
April 25, 1995 |
| New substituted pyridines are prepared by reducing suitably substituted pyridine derivatives. The new substituted pyridines are suitable as active compounds in pharmaceuticals, in particular for the treatment of hyperlipoproteinaemia. |
| 5407948 |
Substituted mono- and bipyridylmethylpyridones |
April 18, 1995 |
| Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones c |
| 5407942 |
Biphenylmethyl-substituted pyridones |
April 18, 1995 |
| Biphenylmethyl-substituted pyridones are prepared by reaction of pyridones with appropriate biphenylmethyl compounds.The biphenylmethyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis. |
| 5401746 |
Substituted pyridines heptenoic acid derivatives, useful for treating arterioscleros, lipopotaem |
March 28, 1995 |
| Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, andR is ##STR2## wherein R.sup.21 --denotes hydrogen or alkyl andR.sup.22 --de |
| 5395840 |
Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
March 7, 1995 |
| Heterocyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting appropriate heterocyclic compounds with cyclohexanebenzyl halides.The compounds can be employed as active compounds in medicaments for the treatment of arterial hypertension and atheroscle |
| 5376671 |
Propenoyl-imidazole derivatives |
December 27, 1994 |
| Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypert |
| 5364942 |
Sulphonylbenzyl-substituted imidazopyridines |
November 15, 1994 |
| Sulphonylbenzyl-substituted imidazopyridines can be prepared by reacting correspondingly substituted imidazopyridines with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted imidazopyridines can be employed as active compounds in medicaments, in particular for the treatment o |
| 5356911 |
Substituted biphenylpyridones |
October 18, 1994 |
| Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. |
| 5354749 |
Sulfonylbenzyl-substituted benzo- and pyridopyridones |
October 11, 1994 |
| Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and pyridopyridones can be employed as active compounds in medicaments, in particular for the |
| 5352687 |
Substituted phenylacetamides |
October 4, 1994 |
| Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can be employed in medicaments for the treatment of high blood pressure and atherosclerosis. |
| 5318980 |
Sulphonylbenzyl-substituted imidazoles |
June 7, 1994 |
| Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicamen |
