| Patent Number |
Title Of Patent |
Date Issued |
| 7335509 |
Stable lipid-comprising drug delivery complexes and methods for their production |
February 26, 2008 |
| Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture |
| 6927213 |
Cationic cholesteryl derivatives containing cyclic polar groups |
August 9, 2005 |
| The present invention discloses compounds which are cationic cholesteryl derivatives having a nitrogen-containing ring structure as their polar head group. These compounds are useful for delivering biologically active substances to cells and for transfecting nucleic acids into cells. |
| 6890557 |
Emulsion formulations for hydrophilic active agents |
May 10, 2005 |
| This invention discloses emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one hydrophilic biologically active molecule and, optionally, cholesteryl ester, and/or apoprotein; |
| 6610321 |
Emulsion formulations for hydrophilic active agents |
August 26, 2003 |
| This invention includes emulsion formulations comprising an aqueous carrier and the following components: triglyceride, cholesterol, phospholipid, at least one charged lipid, at least one hydrophilic biologically active molecule and, optionally, cholesteryl ester, and/or apoprotein; meth |
| 6586003 |
Emulsion and micellar formulations for the delivery of biologically active substances to cells |
July 1, 2003 |
| New emulsion and micelle formulations are described as are complexes of these formulations with biologically active substances. The novel formulations are different from cationic lipid vectors such as cationic liposomes in that the complexes formed between biologically active substan |
| 6583131 |
Cationic cholesteryl derivatives containing cyclic polar groups |
June 24, 2003 |
| The present invention discloses compounds which are cationic cholesteryl derivatives having a nitrogen-containing ring structure as their polar head group. These compounds are useful for delivering biologically active substances to cells and for transfecting nucleic acids into cells. |
| 6509032 |
Cationic amphiphiles |
January 21, 2003 |
| A cationic lipid useful in transfection of cells with DNA is disclosed. |
| 6361791 |
Stable aqueous dispersions including cationic lipids |
March 26, 2002 |
| A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, |
| 6319516 |
Acid salts of cholesterol |
November 20, 2001 |
| A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and relatively resistant to base-catalyzed hydrolysis, a spacer arm and a cationic amino group, |
| 6258792 |
Cationic cholesteryl derivatives containing cyclic polar groups |
July 10, 2001 |
| The present invention discloses compounds which are cationic cholesteryl derivatives having a nitrogen-containing ring structure as their polar head group. These compounds are useful for delivering biologically active substances to cells and for transfecting nucleic acids into cells. |
| 6120794 |
Emulsion and micellar formulations for the delivery of biologically active substances to cells |
September 19, 2000 |
| New emulsion and micelle formulations are described as are complexes of these formulations with biologically active substances. The novel formulations are different from cationic lipid vectors such as cationic liposomes in that the complexes formed between biologically active substan |
| 6008202 |
Stable lipid-comprising drug delivery complexes and methods for their production |
December 28, 1999 |
| Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture |
| 5908777 |
Lipidic vector for nucleic acid delivery |
June 1, 1999 |
| A simple, rapid method for creating a lipidic vector for delivery of a therapeutic molecule entails bringing the molecule into contact with a polycation, thereby forming a complex, and then mixing the complex with an anionic lipidic preparation. Tissue-specific targeting peptides, fusoge |
| 5795587 |
Stable lipid-comprising drug delivery complexes and methods for their production |
August 18, 1998 |
| Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture |
| 5637315 |
Treatment of disease states induced by oxidative stress |
June 10, 1997 |
| Liposome carrier systems, methods and pharmaceutical compositions that target an organ preferentially with high concentrations of at least one therapeutic agent utilize a liposome carrier having a lipid membrane and an aqueous space to deliver pharmacologically active agents, such as fre |
