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Inventor:
Hone; David M.
Address:
Ellicott City, MD
No. of patents:
11
Patents:












Patent Number Title Of Patent Date Issued
7393525 Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors July 1, 2008
A method for introducing and expressing genes in animal cells is disclosed comprising infecting said the animal cells with live invasive bacteria, wherein bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a vaccine antigen, an therapeutic ag
6841345 Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic January 11, 2005
The present inventors have found that certain preparations containing LPS and/or lipid A variants, derivatives, and/or analogs demonstrate non-pyrogenic properties and exhibit anti-viral activities. In particular, non-pyrogenic preparations of LPS, lipid A, LPS antagonists and lipid A
6759241 Adjuvant comprising a lipopolysaccharide antagonist July 6, 2004
LPS preparations, isolated from gram negative bacterial strains that contain at least one mutation in at least one of the htrB and msbB genes, and methods and therapeutics related thereto. The LPS preparations display both LPS antagonist and adjuvant activities.
6682729 Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors January 27, 2004
A method for introducing and expressing genes in animal cells is disclosed comprising infecting the animal cells with live invasive bacteria, wherein the bacteria contain a eukaryotic expression cassette encoding the gene. The gene may encode, e.g., a vaccine antigen, a therapeutic agent
6596477 Treatment and prevention of immunodeficiency virus infection by administration of non-pyrogenic July 22, 2003
The present inventors have found that certain preparations containing LPS and/or lipid A variants, derivatives, and/or analogs demonstrate non-pyrogenic properties and exhibit anti-viral activities. In particular, non-pyrogenic preparations of LPS, lipid A, LPS antagonists and lipid A
6548287 Non-pyrogenic bacterial strains and use of the same April 15, 2003
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the same for introducing endogen
6500419 Method for introducing and expressing RNA in animal cells December 31, 2002
The invention pertains to a method for introducing RNA molecules into eukaryotic cells, wherein the RNA molecules are capable of being translated in the eukaryotic cells or is an antisense RNA or a catalytic RNA, as well as to such bacteria, compositions comprising such bacteria, and
6368604 Non-pyrogenic derivatives of lipid A April 9, 2002
The present inventors have found that certain preparations containing LPS and/or lipid A variants, derivatives, and/or analogs demonstrate non-pyrogenic properties and exhibit anti-viral activities. In particular, non-pyrogenic preparations of LPS, lipid A, LPS antagonists and lipid A
6150170 Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors November 21, 2000
A method for introducing and expressing genes in animal cells is disclosed comprising infecting said animal cells with live invasive bacteria, wherein said bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a vaccine antigen, an therapeutic
5997881 Method of making non-pyrogenic lipopolysaccharide or A December 7, 1999
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the same for introducing endogen
5877159 Method for introducing and expressing genes in animal cells and live invasive bacterial vectors March 2, 1999
A method for introducing and expressing genes in animal cells is disclosed comprising infecting said animal cells with live invasive bacteria, wherein said bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a vaccine antigen, an therapeutic










 
 
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