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Inventor:
Hollingsworth; Rawle I.
Address:
Haslett, MI
No. of patents:
44
Patents:












Patent Number Title Of Patent Date Issued
7498430 Process for the preparation and separation of arabinose and xylose from a mixture of saccharides March 3, 2009
A process for the preparation and separation of the pentoses, xylose and arabinose from mixtures of saccharides by forming acetals is described. D-xylose is a precursor to xylitol, a sweetener, and L-arabinose is a precursor to the drug intermediate (R)-3,4-dihydroxybutyric acid, car
7390825 Process for the preparation of oxazolidinones and method of use thereof June 24, 2008
Substituted oxazolidinone of the formula: ##STR00001## wherein R.sub.2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
7342010 2-thiaquinolizidines and process for the preparation thereof March 11, 2008
A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula: ##STR00001## where x is 0 to 3.
7115706 Polyether polymers and compositions derived therefrom October 3, 2006
Polyether polymers providing a backbone substituted at intervals with electron stabilizing groups containing electron withdrawing groups are described. The polymers capture electrons and are electronegative. The polymers act to solvate alkali metals so that electrons are withdrawn fr
6831176 Process for the preparation of 1, 5-dideoxy-1,5-imino hexitols from oximes or imines December 14, 2004
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6740780 Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines May 25, 2004
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6683185 Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines January 27, 2004
A process for the preparation of 1,5-dideoxy -1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6653482 Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines November 25, 2003
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6653480 Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines November 25, 2003
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6649766 Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines November 18, 2003
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6605724 Process for the preparation of 1,5-dideoxy-1, 5-imino hexitols from oximes or imines August 12, 2003
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6590121 Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines July 8, 2003
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6583297 Process and intermediate compounds for the preparation of pyrrolidines June 24, 2003
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6541601 Unsaturated side chain polyamide polymers April 1, 2003
Polyamide polymers with side chains from a polyamide backbone, preferably containing carbon to carbon unsaturation which provides unique conductive and color change properties, are described. In particular, unsaturation is in the form of side chains from the polyamide backbone, with alig
6518437 Process and intermediate compounds for the preparation of pyrrolidines February 11, 2003
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6492543 Ordered polyacetylenes and process for the preparation thereof December 10, 2002
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6492534 Process and intermediate compounds for the preparation of pyrrolidines December 10, 2002
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6482974 Process and intermediate compounds for the preparation of pyrrolidines November 19, 2002
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6482973 Process and intermediate compounds for the preparation of pyrrolidines November 19, 2002
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6462197 Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines October 8, 2002
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs.
6423867 Process and intermediate compounds for the preparation of pyrrolidines July 23, 2002
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6414163 Process and intermediate compounds for the preparation of pyrrolidines July 2, 2002
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid
6399842 Ordered polyacetylenes and process for the preparation thereof June 4, 2002
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6395868 Ordered polyacetylenes and process for the preparation thereof May 28, 2002
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6392112 Ordered polyacetylenes and process for the preparation thereof May 21, 2002
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6392110 Ordered polyacetylenes and process for the preparation thereof May 21, 2002
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6388085 Ordered polyacetylenes and process for the preparation thereof May 14, 2002
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6288244 Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substitu September 11, 2001
A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-.gamma.-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-.gam
6288239 5-trityloxymethyl-oxazolidinones and process for the preparation thereof September 11, 2001
A method for preparing protected, preferably chiral, 5-trityloxymethyl-oxazolidinone in one step directly from optically active 3-hydroxy-4-trityloxy butyramide is described. Oxazolidinones are an important class of molecules in the pharmaceutical industry especially in the areas of
6288238 Process for the preparation of 5-hydroxymethyl 2-oxazolidinone and novel intermediate September 11, 2001
A process for preparing 5-hydroxymethyl-2-oxazolidinone (1), preferably optically active, in one step from 3,4-boronic acid ester protected 3,4-dihydroxybutyramides (2) is described. The oxazolidinone is important in the pharmaceutical industry especially in the areas of antimicrobials
6274144 Method for generating antibodies to saccharide fragments August 14, 2001
A method for depolymerizing polysaccharides containing into saccharide fragments using ozonolysis is described.
6239311 Process for the preparation of 3,4-dihydroxybutanoic acid and salts and lactones derived therefr May 29, 2001
An improved process for the preparation of 3,4-dihydroxybutanoic acid (1) and salts thereof from a D- or L-hexose source is described. The process uses an alkali metal or alkaline earth metal hydroxide and peroxide oxidizing agent to convert the D- or L-hexose source to (1) by maintainin
6235930 Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substitut May 22, 2001
A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-.gamma.-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-.gam
6194529 Ordered polyacetylenes and process for the preparation thereof February 27, 2001
Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing
6153724 Preparation of cross-linked 2-dimensional polymers with sidedness from .alpha.,.beta.-lactones November 28, 2000
Polymers and processes for synthesizing the polymers from .alpha.,.beta.-unsaturated lactones, particularly 2(5H)-furanone, and amines with side chains. The polymers are used as hydrogels, as polymers that can bind metals and form complexes that are soluble in organic solvents, as po
6114566 4-cyano-3-hydroxybutanoyl hydrazines, derivatives and process for the preparation thereof September 5, 2000
Novel 4-cyano-3-hydroxybutanoyl hydrazides (10), particularly R-chiral intermediates are described. The intermediates are useful in preparing (R)-3-hydroxy-4-trimethylaminobutyric acid (L-carnitine) and R-4-amino-3-hydroxybutyric acid (GABOB) and chiral chemical intermediates which a
6084131 Process for the preparation of protected dihydroxypropyl trialkylammonium salts and derivatives July 4, 2000
A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl)trialkylammonium salts, particularly in chiral form is described. Further
6040464 Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives the March 21, 2000
A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,
6027733 Method for generating saccharide fragments February 22, 2000
A method for depolymerizing polysaccharides containing into saccharide fragments using ozonolysis is described.
5851807 Process for biological material carbon-carbon bond formation December 22, 1998
A process for providing vicinal dimethyl long chain between alkyl groups of organic compounds is described. The process uses intact or disrupted cells of various species of bacteria, particularly Thermoanaerobacter sp., Sarcina sp. and Butyrivibrio sp. The process can be conducted in an
5808107 Process for the preparation of hydroxy substituted gamma butyrolactones September 15, 1998
Preparation of 4-hydroxy substituted butyrolactones is described. A process for the preparation of 3-hydroxybutyrolactone, 1,2,4-trihydroxybutane and 3,4-dihydroxy acid methyl ester from malic acid is particularly described. The preparation of 4-hydroxymethyl-4-hydroxybutyric acid -1-met
5374773 Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof December 20, 1994
A process for the preparation of 3,4-dihydroxybutanoic acid (1) and salts thereof from a glucose source containing 1,4-1inked glucose as a substituent is described. The process uses an alkali metal hdyroxide and hydrogen peroxide to convert the glucose source to (1). The compound (1)
5319110 Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof June 7, 1994
A process for the preparation of 3,4-dihydroxybutanoic acid (1) and salts thereof from a glucose source containing 1,4-linked glucose as a substituent is described. The process uses an alkali metal hdyroxide and hydrogen peroxide to convert the glucose source to (1). The compound (1)
5292939 Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof March 8, 1994
A process for the preparation of 3,4-dihydroxybutanoic acid (1) and salts thereof from a glucose source containing 1,4-linked glucose as a substituent is described. The process uses an alkali metal hdyroxide and hydrogen peroxide to convert the glucose source to (1). The compound (1)










 
 
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