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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Hofmann; Gunter A.
Address:
San Diego, CA
No. of patents:
60
Patents:


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Patent Number Title Of Patent Date Issued
7412284 Apparatus for electroporation mediated delivery for drugs and genes August 12, 2008
A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction
7395110 Electrode apparatus and method for the delivery of drugs and genes into tissue July 1, 2008
An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal
7171264 Intradermal delivery of active agents by needle-free injection and electroporation January 30, 2007
Methods are proved for introducing a biologically active agent into cells of a subject by introducing the agent in a form suitable for electrotransport into a region of tissue of the subject using one or more needle-free injectors, and applying a pulsed electric field to the region o
6947791 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applicati September 20, 2005
The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical
6865416 Electrically induced vessel vasodilation March 8, 2005
The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation
6763264 Method of treatment using electroporation mediated delivery of drugs and genes July 13, 2004
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6748265 Electrode apparatus and method for the delivery of drugs and genes into tissue June 8, 2004
An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal sur
6746441 Flow-through electroporation system for ex vivo gene therapy June 8, 2004
A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating
6697669 Skin and muscle-targeted gene therapy by pulsed electrical field February 24, 2004
The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic
6654636 Skin and muscle-targeted gene therapy by pulsed electrical field November 25, 2003
The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic
6569149 Method of treatment using electroporation mediated delivery of drugs and genes May 27, 2003
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6520950 Method of electroporation-enhanced delivery of active agents February 18, 2003
Methods are provided for introducing a biologically active agent into cells of a subject by injecting the agent with a needle-free injector and applying a pulsed electric field to the region of tissue to cause electrotransport of the agent into cells of the tissue. Preferably the age
6516223 Apparatus for electroporation mediated delivery for drugs and genes February 4, 2003
A device for in vivo electroporation therapy comprising an electrode applicator with at least two pairs of electrodes arranged relative to one another to form an array and a power supply. The device is used to generate an electric field in a biological sample and effect introduction
6451002 Method of treatment using electroporation mediated delivery of drugs and genes September 17, 2002
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6418341 Needle electrode assembly for electroporation mediated delivery of genes and drugs July 9, 2002
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
6347247 Electrically induced vessel vasodilation February 12, 2002
The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation
6302874 Method and apparatus for electrically assisted topical delivery of agents for cosmetic applicati October 16, 2001
The present invention is based on the development of a method for cosmetic delivery of L-ascorbic acid-containing compositions to the layer of the skin wherein collagen formation takes place to enhance production of collagen and thereby combat some of the effects of aging and oxy-radical
6266560 Electrically assisted transdermal method and apparatus for the treatment of erectile dysfunction July 24, 2001
A non-invasive method is provided for treating erectile dysfunction using electroporation enhanced with delivery of a vasoactive or androgenic composition applied to the penis which affords an alternative treatment for patients afflicted with erectile dysfunction (ED). Sufficient electri
6241701 Apparatus for electroporation mediated delivery of drugs and genes June 5, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6233482 Method of electroporation mediated delivery of drugs and genes May 15, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6216034 Method of programming an array of needle electrodes for electroporation therapy of tissue April 10, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6208893 Electroporation apparatus with connective electrode template March 27, 2001
An electrode template apparatus, includes a three dimensional support member having opposite surfaces, a plurality of bores extending through the support member and through the opposite surfaces, a plurality of conductors on the member separately connected to the plurality of bores, a
6192270 Apparatus and method for the delivery of drugs and genes into tissue February 20, 2001
An electrode assembly for an apparatus for and a method of trans-surface molecular delivery, including a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a first electrode disposed on at
6181964 Minimally invasive apparatus and method to electroporate drugs and genes into tissue January 30, 2001
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6150148 Electroporation apparatus for control of temperature during the process November 21, 2000
An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing and temperature profile scheme. The apparatus includes a cuvette holder with a Peltier device forming part of the electrode structures that form part of the holder.
6132419 Electroporetic gene and drug therapy October 17, 2000
A method and apparatus are provided for introducing molecules such as genes and pharmaceutical compounds into living blood cells of a patient for therapeutic purposes. A device is placed into contact with the body of the patient for generating an electric field at a preselected location
6120493 Method for the introduction of therapeutic agents utilizing an electroporation apparatus September 19, 2000
A method is provided for the introduction of an agent to a neoplastic cell for electroporating the cell, including contacting the cell with an electrode template apparatus. The electrode template apparatus is utilized to apply an electric field to the cell in order to introduce the agent
6096020 Electroporation employing user-configured pulsing scheme August 1, 2000
An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing scheme. Advantageously, one such pulse includes a low voltage pulse of a first duration, immediately followed by a high voltage of a second duration, immediately follow
6068650 Method of Selectively applying needle array configurations May 30, 2000
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described, tumors treated by a combination of electroporation using the apparatus and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, a method of EPT ut
6055453 Apparatus for addressing needle array electrodes for electroporation therapy April 25, 2000
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6027488 Flow-through electroporation system for ex vivo gene therapy February 22, 2000
A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating
6014584 Electroporation therapy apparatus January 11, 2000
A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In
6009347 Electroporation apparatus with connective electrode template December 28, 1999
An electrode template apparatus, comprises a three dimensional support member having opposite surfaces, a plurality of bores extending through the support member and through the opposite surfaces, a plurality of conductors on the member separately connected to the plurality of bores, a
6009345 Method and apparatus for a combination of electroporation and iontophoresis for the delivery of December 28, 1999
An apparatus for transdermal molecular delivery, comprises a first electrode assembly having an anode and a cathode in closely spaced relation for engaging the stratum corneum through which to apply an electric field, first power supply including a first circuit connected to the firs
5993434 Method of treatment using electroporation mediated delivery of drugs and genes November 30, 1999
A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.
5968006 Method and apparatus for a combination of electroporation and iontophoresis for the delivery of October 19, 1999
An apparatus and method for transdermal molecular delivery, comprises a first electrode assembly having an anode and a cathode in closely spaced relation for engaging the stratum corneum through which to apply an electric field, a second electrode assembly spaced from the first elect
5944710 Electroporation-mediated intravascular delivery August 31, 1999
A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least o
5869326 Electroporation employing user-configured pulsing scheme February 9, 1999
An electroporation method and apparatus generating and applying an electric field according to a user-specified pulsing scheme. Advantageously, one such pulse includes a low voltage pulse of a first duration, immediately followed by a high voltage of a second duration, immediately follow
5810762 Electroporation system with voltage control feedback for clinical applications September 22, 1998
An electrode apparatus for the application of electroporation to a portion of the body of a patient, comprising a support member, a pair of electrodes adjustably mounted on the support member for movement toward and away from one another for positioning on opposite sides of a body po
5704908 Electroporation and iontophoresis catheter with porous balloon January 6, 1998
An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient includes an elongated catheter having a proximal end and a distal end and a guide wire extending from the proximal end to the distal end, an inflatable balloo
5702359 Needle electrodes for mediated delivery of drugs and genes December 30, 1997
An electrode apparatus for the application of electroporation to a portion of the body of a patient, comprises a support member, a pair of electrodes adjustably mounted on the support member for movement toward and away from one another for positioning on opposite sides of a body portion
5688233 Electronincorporation enhanced transdermal delivery of molecules November 18, 1997
A method of transdermal molecular delivery comprising molecules to be delivered mixed with particles, contacting a selected area of a skin surface with the particles and molecules, applying a pulsed electric field of sufficient amplitude and duration to induce dielectric breakdown of the
5676646 Flow through electroporation apparatus October 14, 1997
A flow through apparatus for implanting molecules into living blood cells of a patient, comprises a housing including an elongated flow through chamber having an inlet and an outlet at opposite ends thereof, a pair of elongated spaced apart parallel electrodes disposed between the inlet
5545130 Flow through electroporation method August 13, 1996
A flow through apparatus for implanting molecules into living blood cells of a patient, comprises a housing including an elongated flow through chamber having an inlet and an outlet at opposite ends thereof, a pair of elongated spaced apart parallel electrodes disposed between the inlet
5507724 Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cel April 16, 1996
A catheter device having a plurality of axially extending, circumferentially spaced electrodes carried thereby, infusion means for infusion of fluid medium for carrying genes and drugs, and expandable sealing means at each end of the electrodes for sealing off and confining the thera
5501662 Implantable electroporation method and apparatus for drug and gene delivery March 26, 1996
A method and apparatus are provided for introducing molecules such as genes and pharmacological compounds into living blood cells of a patient for therapeutic purposes. A device is implanted into the body of the patient for generating an electric field at a preselected location within a
5464386 Transdermal drug delivery by electroincorporation of vesicles November 7, 1995
A method of transdermal molecular delivery comprises the steps of encapsulating molecules to be delivered in a vesicle, contacting a selected area of a tissue surface with a solution of the vesicles, and applying a pulsed electric field of sufficient amplitude to induce dielectric br
5462520 Transsurface drug delivery by electrofusion of microbubbles to the tissue surface October 31, 1995
A method of transtissue molecular delivery comprises encapsulating molecules to be delivered in a microbubble carrier, contacting a selected area of a tissue surface with a solution of the encapsulated molecules, and applying an electric field of sufficient amplitude to induce electr
5439440 Electroporation system with voltage control feedback for clinical applications August 8, 1995
A method and apparatus are provided for introducing macromolecules such as genes and pharmacological compounds into cells of a patient for therapeutic purposes. An apparatus for the therapeutic application of electroporation to a portion of the anatomy of a patient, includes adjustab
5318514 Applicator for the electroporation of drugs and genes into surface cells June 7, 1994
An apparatus for implanting macromolecules such as genes, DNA or pharmaceuticals into a preselected surface tissue region of of a patient. An applicator having a plurality of electrodes is provided for contacting a surface tissue region of a patient. A mechanism associated with the a
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