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Inventor:
Hickory; Brian S.
Address:
Wildwood, MO
No. of patents:
38
Patents:












Patent Number Title Of Patent Date Issued
7700658 (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting chol April 20, 2010
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
7629363 Diaryl substituted pyridinones December 8, 2009
Disclosed are compounds Formula I ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, R.sub.3/R.sub.4, and R.sub.5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kin
7253211 (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting chol August 7, 2007
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
7196118 Amidino compounds useful as nitric oxide synthase inhibitors March 27, 2007
The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides
7122536 (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting chol October 17, 2006
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
7102013 Methods of making amidino compounds useful as nitric oxide synthase inhibitors September 5, 2006
Method of making an alpha-amino acid compound having the structure of Formula 32: ##STR00001## comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: ##STR00002## where the substituents are described herein.
7067540 Substituted pyridinones June 27, 2006
Disclosed are compounds Formula I ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kin
6914158 Amidino compounds useful as nitric oxide synthase inhibitors July 5, 2005
The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides
6803388 (R)-Chiral halogenated substituted n,n-bis-phenyl aminoalcohol compounds useful for inhibiting c October 12, 2004
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
6765023 Use of substituted N, N-disubstituted reverse aminoalcohol compounds useful for inhibiting chole July 20, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6723753 Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester tra April 20, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6710089 Substituted N-fused-phenyl-N-benzyl aminoalcohol compounds useful for inhibiting cholesteryl est March 23, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6699898 Substituted N,N-disubstituted non-fused heterocyclo amino compounds useful for inhibiting choles March 2, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6696472 Substituted N-phenoxy-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester tr February 24, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6696435 Substituted N,N-disubstituted fused-heterocyclo amino compounds useful for inhibiting cholestery February 24, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6683113 (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting January 27, 2004
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
6677382 Substituted N,N-bis-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transf January 13, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6677380 Substituted N, N-disubstituted mercapto amino compounds useful for inhibiting cholesteryl ester January 13, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6677375 Substituted N,N-bis-benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transf January 13, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6677353 Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds useful for inhibiting cholesteryl es January 13, 2004
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6677341 (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibitin January 13, 2004
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
6586474 Amidino compounds useful as nitric oxide synthase inhibitors July 1, 2003
The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides
6586433 Substituted N-heteroaryl-N-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester July 1, 2003
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6583183 Substituted n-phenyl-n-fused-benzyl aminoalcohol compounds useful for inhibiting cholesteryl est June 24, 2003
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6544974 (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting chol April 8, 2003
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
6521607 (R)-chiral halogenated substituted N-phenoxy N-phenyl aminoalcohol compounds useful for inhibiti February 18, 2003
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atheroscl
6479552 Use of substituted N, N-disubstituted diamino compounds for inhibiting cholesteryl ester transfe November 12, 2002
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6476075 Use of substituted N, N-bis-benzyl aminoalcohol compounds inhibiting cholesteryl ester transfer November 5, 2002
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6476057 Use of substituted N, N-disubstituted cycloalkyl aminoalcohol compounds for inhibiting cholester November 5, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6462092 Use of substituted N, N-disubstituted reverse aminoalcohol compounds for inhibiting cholesteryl October 8, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6458852 Use of substituted N, N-bis-phenyl aminoalcohol compounds for inhibiting cholesteryl ester trans October 1, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6458849 use of substituted N,N-disubstituted mercapto amino compounds for inhibiting cholesteryl ester t October 1, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkyamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6458803 Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester tra October 1, 2002
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6455519 Use of substituted N, N-disubstituted fused-heterocyclo amino compounds for inhibiting cholester September 24, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6451830 Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting choles September 17, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6451823 Use of substituted N-phenoxy-N-phenyl aminoalcohol compounds for inhibiting cholesteryl ester tr September 17, 2002
The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other
6448295 Use of substituted N-fused-phenyl-N-benzyl aminoalcohol compounds for inhibiting cholesteryl est September 10, 2002
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other co
6403830 Amidino compound and salts thereof useful as nitric oxide synthase inhibitors June 11, 2002
The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.










 
 
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