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Inventor:
Hellerstein; Marc K.
Address:
Kensington, CA
No. of patents:
19
Patents:












Patent Number Title Of Patent Date Issued
8129335 Method for automated, large-scale measurement of the molecular flux rates of the proteome or the March 6, 2012
Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates--synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites inn living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, b
8084016 Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or December 27, 2011
Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessib
8021644 Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-athero September 20, 2011
The present invention relates to biochemical methods for determining reverse cholesterol transport. Specifically, the rates of the two arms of reverse cholesterol transport (HDL or first arm and post-HDL or second arm) are obtained by measuring the flow of unlabeled cholesterol from
8005623 Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as b August 23, 2011
The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molec
7910323 Methods for identifying the effect of a drug agent on the metabolism of sugars and fats in an in March 22, 2011
Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabe
7504233 Methods for determining the metabolism of sugars and fats in an individual March 17, 2009
Provided herein are methods for determining the metabolism of one or more sugars and/or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabe
7449171 Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or November 11, 2008
Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the rates of biosynthesis and breakdown of biological molecules inaccessible or not easily accessib
7410633 Measurement of protein synthesis rates in humans and experimental systems by use of isotopically August 12, 2008
Provided herein are methods for measuring protein biosynthesis by using .sup.2H.sub.2O or radioactive .sup.3H.sub.2O and applicable uses thereof.
7357913 Methods for detecting, prognosing, or monitoring a disorder by comparing relative flux rates of April 15, 2008
The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, includi
7307059 Measurement of protein synthesis rates in humans and experimental systems by use of isotopically December 11, 2007
Provided herein are methods for measuring protein biosynthesis by using .sup.2H.sub.2O or radioactive .sup.3H.sub.2O and applicable uses thereof.
7262020 Methods for comparing relative flux rates of two or more biological molecules in vivo through a August 28, 2007
The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, includi
7255850 Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-athero August 14, 2007
The present invention relates to biochemical methods for determining reverse cholesterol transport. Specifically, the rates of the two arms of reverse cholesterol transport (HDL or first arm and post-HDL or second arm) are obtained by measuring the flow of unlabeled cholesterol from
7022834 Isotopically labelled DNA April 4, 2006
The present invention relates to a labeled deoxyribonucleic acid (DNA) molecule. In one aspect, the labeled DNA molecule is produced by contacting a cell or subject with a detectable amount of a stable isotope label which is incorporated into DNA via the de novo nucleotide synthesis
7001587 Measurement of protein synthesis rates in humans and experimental systems by use of isotopically February 21, 2006
Provided herein are methods for measuring protein biosynthesis by using .sup.2H.sub.2O or radioactive .sup.3H.sub.2O and applicable uses thereof.
6808875 Methods for screening cellular proliferation using isotope labels October 26, 2004
The present invention relates to methods for measuring the proliferation and destruction rates of cells by measuring deoxyribonucleic acid (DNA) synthesis and/or destruction. In particular, the methods utilize non-radioactive stable isotope labels to endogenously label DNA synthesize
6461806 Methods for measuring cellular proliferation and destruction rates in vitro and in vivo October 8, 2002
The present invention relates to methods for measuring the proliferation and destruction rates of cells by measuring deoxyribonucleic acid (DNA) synthesis and/or destruction. In particular, the methods utilize non-radioactive stable isotope labels to endogenously label DNA synthesize
6010846 Methods for measuring cellular proliferation and destruction rates in vitro and in vivo January 4, 2000
The present invention relates to methods for measuring the proliferation and destruction rates of cells by measuring deoxyribonucleic acid (DNA) synthesis and/or destruction. In particular, the methods utilize non-radioactive stable isotope labels to endogenously label DNA synthesize
5910403 Methods for measuring cellular proliferation and destruction rates in vitro and in vivo June 8, 1999
The present invention relates to methods for measuring the proliferation and destruction rates of cells by measuring deoxyribonucleic acid (DNA) synthesis. In particular, the methods utilize non-radioactive stable isotope labels to endogenously label DNA synthesized through the de novo
5338686 Method for measuring in vivo synthesis of biopolymers August 16, 1994
A method for determining the mass isotope enrichment of a subunit from which a biopolymer is formed, and the rates of synthesis and decay of the biopolymer. The mass isotope enrichment of the subunit is determined by comparing the mass isotopomer distribution of the biopolymer after










 
 
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