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Inventor: Harmange; Jean-Christophe
Address: Andover, MA
No. of patents: 21
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 8217177 |
Fused heterocyclic derivatives and methods of use |
July 10, 2012 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 8212041 |
Fused heterocyclic derivatives and methods of use |
July 3, 2012 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 8198448 |
Fused heterocyclic derivatives and methods of use |
June 12, 2012 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 8178557 |
Compounds and methods of use |
May 15, 2012 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 8088794 |
Substituted amide derivatives and methods of use |
January 3, 2012 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 8017601 |
Bis-aryl kinase inhibitors and method |
September 13, 2011 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 7915306 |
Macrocyclic compounds useful as pharmaceuticals |
March 29, 2011 |
| The present invention provides compositions comprising compounds having formula (I): ##STR00001## and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased |
| 7915287 |
Substituted heterocycles and methods of use |
March 29, 2011 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 7858623 |
Substituted amide derivatives and methods of use |
December 28, 2010 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 7799827 |
Macrocyclic compounds useful as pharmaceuticals |
September 21, 2010 |
| The present invention provides compounds having formula (I): ##STR00001## and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy |
| 7795254 |
Benzomorpholine derivatives and methods of use |
September 14, 2010 |
| Selected benzomorpholine compounds, including 7-((6,7-bis(methyloxy)-4-quinolinyl)oxy)-N-(5 -methyl-3-isoxazolyl)-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel com |
| 7759344 |
Bis-aryl amide derivatives and methods of use |
July 20, 2010 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as c-Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatme |
| 7687522 |
Substituted pyridines and pyrimidines and their use in treatment of cancer |
March 30, 2010 |
| Selected pyridine and pyrimidine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, p |
| 7626030 |
Compounds and methods of use |
December 1, 2009 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 7531553 |
Heterocyclic compounds and methods of use |
May 12, 2009 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and |
| 7524883 |
Eponemycin and epoxomicin analogs and uses thereof |
April 28, 2009 |
| The present invention provides compounds having formula (1): wherein R.sub.1-R.sub.6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in th |
| 7435823 |
Compounds and methods of use |
October 14, 2008 |
| Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment |
| 7115617 |
Amino-substituted pyrimidinyl derivatives and methods of use |
October 3, 2006 |
| The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer. |
| 6939874 |
Substituted pyrimidinyl derivatives and methods of use |
September 6, 2005 |
| The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer. |
| 6107345 |
Benzocyclobutane compounds |
August 22, 2000 |
| A compound of formula (I): ##STR1## wherein: Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, which may be identical or different, represent a group as defined in the description,X represents oxygen, S(O).sub.p, --(CH.sub.2).sub.n -- or --CH.sub.2 --Y--CH.sub.2 -- wherein p, n and Y are as define |
| 6025356 |
Disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth[1,2-b]-1,4-oxazines |
February 15, 2000 |
| New compounds of formula: ##STR1## wherein: A represents alkyl, alkenyl, alkynyl, cycloalkylalkyl or aralkyl, andE represents: ##STR2## in racemic form or in the form of optical isomers, and the addition salts thereof with pharmaceutically acceptable acids.Those compounds ma |
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