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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Harmange; Jean-Christophe
Address:
Andover, MA
No. of patents:
21
Patents:












Patent Number Title Of Patent Date Issued
8217177 Fused heterocyclic derivatives and methods of use July 10, 2012
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
8212041 Fused heterocyclic derivatives and methods of use July 3, 2012
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
8198448 Fused heterocyclic derivatives and methods of use June 12, 2012
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
8178557 Compounds and methods of use May 15, 2012
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
8088794 Substituted amide derivatives and methods of use January 3, 2012
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
8017601 Bis-aryl kinase inhibitors and method September 13, 2011
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
7915306 Macrocyclic compounds useful as pharmaceuticals March 29, 2011
The present invention provides compositions comprising compounds having formula (I): ##STR00001## and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased
7915287 Substituted heterocycles and methods of use March 29, 2011
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
7858623 Substituted amide derivatives and methods of use December 28, 2010
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
7799827 Macrocyclic compounds useful as pharmaceuticals September 21, 2010
The present invention provides compounds having formula (I): ##STR00001## and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy
7795254 Benzomorpholine derivatives and methods of use September 14, 2010
Selected benzomorpholine compounds, including 7-((6,7-bis(methyloxy)-4-quinolinyl)oxy)-N-(5 -methyl-3-isoxazolyl)-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, are effective for prophylaxis and treatment of diseases, such as VEGF mediated diseases. The invention encompasses novel com
7759344 Bis-aryl amide derivatives and methods of use July 20, 2010
Selected compounds are effective for prophylaxis and treatment of diseases, such as c-Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatme
7687522 Substituted pyridines and pyrimidines and their use in treatment of cancer March 30, 2010
Selected pyridine and pyrimidine compounds of Formula I are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, p
7626030 Compounds and methods of use December 1, 2009
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
7531553 Heterocyclic compounds and methods of use May 12, 2009
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and
7524883 Eponemycin and epoxomicin analogs and uses thereof April 28, 2009
The present invention provides compounds having formula (1): wherein R.sub.1-R.sub.6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in th
7435823 Compounds and methods of use October 14, 2008
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment
7115617 Amino-substituted pyrimidinyl derivatives and methods of use October 3, 2006
The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
6939874 Substituted pyrimidinyl derivatives and methods of use September 6, 2005
The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.
6107345 Benzocyclobutane compounds August 22, 2000
A compound of formula (I): ##STR1## wherein: Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, which may be identical or different, represent a group as defined in the description,X represents oxygen, S(O).sub.p, --(CH.sub.2).sub.n -- or --CH.sub.2 --Y--CH.sub.2 -- wherein p, n and Y are as define
6025356 Disubstituted trans-3,4,4a,5,6,10b-hexahydro-2H-naphth[1,2-b]-1,4-oxazines February 15, 2000
New compounds of formula: ##STR1## wherein: A represents alkyl, alkenyl, alkynyl, cycloalkylalkyl or aralkyl, andE represents: ##STR2## in racemic form or in the form of optical isomers, and the addition salts thereof with pharmaceutically acceptable acids.Those compounds ma










 
 
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