| Patent Number |
Title Of Patent |
Date Issued |
| 7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres |
December 2, 2008 |
| This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promotin |
| 7410995 |
N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders |
August 12, 2008 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked sulfonamides of heterocyclic thioesters. |
| 7338976 |
Heterocyclic esters or amides for vision and memory disorders |
March 4, 2008 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic esters and amides. |
| 7282510 |
Small molecule inhibitors of rotamase enzyme activity |
October 16, 2007 |
| This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or ro |
| 7265150 |
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory |
September 4, 2007 |
| This invention relates to novel compositions and uses of N-heterocyclic carboxylic acids and carboxylic acid isosteres for treating a vision disorder, improving vision, treating memory impairment or enhancing memory performance in an animal. |
| 7253169 |
Aza compounds, pharmaceutical compositions and methods of use |
August 7, 2007 |
| The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. |
| 7153883 |
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
December 26, 2006 |
| This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treati |
| 7098211 |
Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodie |
August 29, 2006 |
| The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, s |
| 7078424 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres |
July 18, 2006 |
| This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promotin |
| 7056935 |
Rotamase enzyme activity inhibitors |
June 6, 2006 |
| This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal degeneration. |
| 6984639 |
Heterocyclic ketone and thioester compounds and uses |
January 10, 2006 |
| This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative dis |
| 6974823 |
Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same |
December 13, 2005 |
| The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; |
| 6943187 |
Pyrrolidine derivative hair growth compositions and uses |
September 13, 2005 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives. |
| 6677376 |
Non-peptidic cyclophilin binding compounds and their use |
January 13, 2004 |
| The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interac |
| 6593362 |
Non-peptidic cyclophilin binding compounds and their use |
July 15, 2003 |
| This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promoting hair growth, in treating infe |
| 6509477 |
Small molecule inhibitors of rotamase enzyme activity |
January 21, 2003 |
| This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity. |
| 6506788 |
N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
January 14, 2003 |
| The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance. |
| 6500959 |
Pyrrolidine derivatives and processes for preparing same |
December 31, 2002 |
| This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or ro |
| 6500843 |
Inhibitors of rotamase enzyme activity |
December 31, 2002 |
| This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase |
| 6486151 |
N-oxides of heterocyclic esters, amides, thioesters, and ketones |
November 26, 2002 |
| This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particular |
| 6462072 |
Cyclic ester or amide derivatives |
October 8, 2002 |
| This invention relates to low molecular weight, small molecule cyclic esters and amides having an affinity for FKBP-type immunophilins, pharmaceutical compositions comprising the same, and methods of using the same to effect a neuronal activity. |
| 6444643 |
Methods of using inhibitors of cyclophilin rotamase activity to affect neurological activity |
September 3, 2002 |
| This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rot |
| 6429215 |
N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
August 6, 2002 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone. |
| 6417209 |
Heterocyclic ketone and thioester compounds and uses |
July 9, 2002 |
| This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative dis |
| 6417189 |
AZA compounds, pharmaceutical compositions and methods of use |
July 9, 2002 |
| The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. |
| 6399648 |
N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
June 4, 2002 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-Oxides of heterocyclic esters, amides, thioesters, or ketones |
| 6395758 |
Small molecule carbamates or ureas for vision and memory disorders |
May 28, 2002 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule carbamates and ureas. |
| 6384056 |
Heterocyclic thioesters or ketones for vision and memory disorders |
May 7, 2002 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic thioesters and ketones. |
| 6376517 |
Pipecolic acid derivatives for vision and memory disorders |
April 23, 2002 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using pipecolic acid derivatives. |
| 6339101 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory diso |
January 15, 2002 |
| This invention relates to novel compositions and uses of a N-linked sulfonamide of an N-heterocylic carboxylic acid or isostere thereof for treating a vision disorder or improving vision or treating memory impairment or enhancing memory performance in an animal. |
| 6337340 |
Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vi |
January 8, 2002 |
| This invention relates to novel compositions and uses of carboxylic acid or isostere of a heterocyclic ring compound having two or more heteroatoms within the heterocyclic ring and wherein the heterocyclic ring has at least one substituent attached thereto, the substituent selected from |
| 6335348 |
Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
January 1, 2002 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal, using pipecolic acid derivatives. |
| 6333340 |
Small molecule sulfonamides for vision and memory disorders |
December 25, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal using small molecule sulfonamides. |
| 6331537 |
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
December 18, 2001 |
| This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and promoting hair growth, for trea |
| 6294551 |
N-linked sulfonamides of heterocyclic thioesters |
September 25, 2001 |
| This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl |
| 6291510 |
Small molecule inhibitors of rotamase enzyme activity |
September 18, 2001 |
| This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity. |
| 6274617 |
Heterocyclic ester and amide hair growth compositions and uses |
August 14, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic esters or amides. |
| 6274607 |
N-linked ureas and carbamates of heterocyclic thioesters |
August 14, 2001 |
| This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly |
| 6274602 |
Heterocyclic thioester and ketone hair growth compositions and uses |
August 14, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using heterocyclic thioesters and ketones. |
| 6251892 |
N-oxides of heterocyclic esters, amides, thioesters, and ketones |
June 26, 2001 |
| This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particula |
| 6245783 |
Method of using neurotrophic sulfonamide compounds |
June 12, 2001 |
| This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or r |
| 6242468 |
Carbamate and urea compositions and neurotrophic uses |
June 5, 2001 |
| This invention relates to pharmaceutical compositions and methods for effecting a neuronal activity using low molecular weight, small molecule carbamates and ureas having an affinity for FKBP-type immunophilins. |
| 6239164 |
Pyrrolidine carboxylate and pyrrolidine amide hair revitalizing agents |
May 29, 2001 |
| This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate and pyrrolidine amide compounds. |
| 6218544 |
Heterocyclic esters and amides |
April 17, 2001 |
| This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, |
| 6218424 |
Heterocyclic ketone and thioester compounds and uses |
April 17, 2001 |
| This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative dis |
| 6218423 |
Pyrrolidine derivatives for vision and memory disorders |
April 17, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using pyrrolidine derivatives. |
| 6200972 |
Heterocyclic esters and amides |
March 13, 2001 |
| This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, |
| 6191125 |
Small molecule pipecolic acid derivative hair growth compositions and uses |
February 20, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pipecolic acid derivatives. |
| 6187806 |
N-linked sulfone of heterocyclic thioester hair growth compositions and uses |
February 13, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-linked sulfonamides of heterocyclic thioesters. |
| 6187796 |
Sulfone hair growth compositions and uses |
February 13, 2001 |
| This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using small molecule sulfonamides. |
