| Patent Number |
Title Of Patent |
Date Issued |
| RE30561 |
Vinca alkaloid intermediates |
March 31, 1981 |
| 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates. |
| RE30560 |
Oxazolidinedione derivatives of Vinca alkaloids |
March 31, 1981 |
| 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates. |
| 4357334 |
Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
November 2, 1982 |
| VLB 3-(2-chloroethyl)carboxamide, the corresponding 4-desacetyl derivative and salts thereof, useful in treatment of neoplasms in pharmaceutical dosage forms. |
| 4160767 |
Vinca alkaloid intermediates |
July 10, 1979 |
| 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates. |
| 4096148 |
Oxazolidinedione derivatives of Vinca alkaloids |
June 20, 1978 |
| 3-Spiro-5"-oxazolidine-2",4"-dione derivatives of Vinca alkaloids, useful as anti-tumor agents and as intermediates. |
| 4087429 |
5' Acetoxy vinblastine 4' bis-sulfite |
May 2, 1978 |
| Vincaleukoblastine (VLB, vinblastine) is reacted with thionyl chloride to form a bis-sulfite ester which is converted to various 5'-oxygenated derivatives. |
| 4075214 |
Preparation of leurosidine and novel leurosidine 4'-ethers and esters |
February 21, 1978 |
| Vincaleukoblastine (VLB, vinblastine) is converted to leurosidine, its 4' epimer, by reaction with thionyl chloride to form a bis-sulfite ester followed by treatment of the bis-sulfite ester with silver perchlorate. The bis-sulfite ester is covertible to novel 4' ethers by treatment with |
| 4053698 |
Acylation of pyrazofurin |
October 11, 1977 |
| A process for preparing new compounds which are N- and O-acylates of pyrazofurin comprises first selective mono-N-acylation under non-basic conditions in an organic solvent. The mono-N-acylate so formed is further acylated under mild basic conditions to provide a tetra-acylated or pe |
| 4029663 |
Dimeric anhydro-vinca derivatives |
June 14, 1977 |
| Dimeric Vinca alkaloids are converted to three separable anhydro derivatives, useful as mitotic inhibitors or as intermediates for the preparation of other oncogenetically active alkaloids. |
| 3960836 |
Acylated derivatives of pyrazofurin and process for their preparation |
June 1, 1976 |
| A process for preparing new compounds which are N- and O-acylates of pyrazofurin comprises first selective mono-N-acylation under non-basic conditions in an organic solvent. The mono-N-acylate so formed is further acylated under mild basic conditions to provide a tetra-acylated or pe |
