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Inventor:
Gunzler-Pukall; Volkmar
Address:
Marburg, DE
No. of patents:
12
Patents:












Patent Number Title Of Patent Date Issued
5679583 Monoclonal antibodies for the selective immunological determination of intact procollagen peptid October 21, 1997
It is possible with the aid of a monoclonal antibody which is specifically directed against an epitope of amino-terminal procollagen peptide (type III) which is not present on the fragment Col 1, and of a second monoclonal or polyclonal antibody against an epitope of amino-terminal p
5620996 Sulfonamidocarbonyl pyridine-2-carboxesteramides and their pyridine-N-oxide compounds and their April 15, 1997
The invention relates to sulfonamidocarbonylpyridine-2-carboxesteramides and their pyridine-N-oxides according to the formula I ##STR1## Said compounds are used as pharmaceuticals against fibrotic disorders, as fibrosuppressants and as inhibitors of proline hydroxylase.
5614537 2,4-and 2,5-bistetrazolylpyridines, a process for the preparation thereof and the use thereof as March 25, 1997
The invention relates 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
5610172 Sulfonamidocarbonylpyridine-2-carboxamides and pyridine-n-oxides which are useful as pharmaceuti March 11, 1997
Sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation, and their use as pharmaceuticalsThe invention relates to sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-N-oxides according to the formula I ##STR1## Said compounds ar
5607954 Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process March 4, 1997
The invention relates to sulfonamido- and sulfonamido-carbonylpyridine-2-carboxa of the formula I ##STR1## and their use as pharmaceuticals, in particular against fibrotic diseases.
5519038 N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamines May 21, 1996
The invention relates to N,N'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides of the formula I ##STR1## wherein R.sup.1, R.sup.2, n, R.sup.1', R.sup.2' and n' have the meanings given. The compounds inhibit proline hydroxylase and lysine hydroxylase and are suitable as f
5482953 2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals January 9, 1996
The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.
5428046 Acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, p June 27, 1995
The invention relates to acylsulfonamido- and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides of the formula I ##STR1## in whichThe compounds are suitable as medicaments against fibrotic diseases.
5260323 2,4- and 2,5-substituted pyridine-N-oxides, processes for their preparation and their use November 9, 1993
2,4- and 2,5-substituted pyridine-N-oxides are provided which are effective as fibrosuppressives and immunosuppressives. Said compounds are also suitable for the treatment of disorders of the metabolism of collagen and collagen-like substances or the biosynthesis of Clq.
5240921 Cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides, processes for their preparation and th August 31, 1993
The invention relates to cyclic pyridine-2,4- and -2,5-dicarboxylic acid diamides of the formula I ##STR1## in which n and X have the meanings given. The compounds according to the invention inhibit proline hydroxylase and lysine hydroxylase and can accordingly be employed as fib
5204338 Oxalylamino acid derivatives and their use as medicaments for inhibiting proline hydroxylase April 20, 1993
The invention relates to oxalylamino acid derivatives of the formula I ##STR1## in which R and R' are identical or different and are C.sub.1 -C.sub.6 -alkyl or hydrogen,R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.2 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.3 -alkoxy,
5130317 Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals ba July 14, 1992
Pyrimidine-4,6-dicarboxylic acid diamides, processes for the use thereof, and pharmaceuticals based on these compoundsThe invention relates to pyrimidine-4,6-dicarboxylic acid diamides of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings given. The compounds a










 
 
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