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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Gregory; Richard J.
Address:
Westford, MA
No. of patents:
15
Patents:












Patent Number Title Of Patent Date Issued
7105156 Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferati September 12, 2006
Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56.sup.RB protein, a fragment of the p56.sup.RB protein, and the gene encoding p56.sup.RB protein to alter the cell cycle progr
7053062 Compositions and methods for inducing gene expression May 30, 2006
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and n
6902731 Methods of treating hyperproliferative disorders using retinoblastoma fusion proteins June 7, 2005
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
6485720 Transgene expression systems November 26, 2002
The present invention relates to transgene expression systems, related compositions comprising the transgene expression systems, and methods of making and using them. Preferred systems employ an adenovirus transgene expression vector comprising DNA encoding a transgene which codes for a
6432927 Compositions and methods for inducing gene expression August 13, 2002
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and n
6379927 Retinoblastoma fusion proteins April 30, 2002
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
6358507 Transgene expression systems March 19, 2002
The present invention relates to transgene expression systems, related compositions comprising the transgene expression systems, and methods of making and using them. Preferred systems employ an adenovirus transgene expression vector comprising DNA encoding a transgene which codes for a
6331524 Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy December 18, 2001
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at
6100086 Transgene expression systems August 8, 2000
The present invention relates to transgene expression systems, related pharmaceutical compositions, and methods of making and using them. Preferred systems employ an adenovirus transgene expression vector comprising DNA sequence encoding a transgene which codes for a desired product,
6093567 Gene therapy for cystic fibrosis July 25, 2000
Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
6074850 Retinoblastoma fusion polypeptides June 13, 2000
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
6020191 Adenoviral vectors capable of facilitating increased persistence of transgene expression February 1, 2000
The invention is directed to novel adenoviral vectors which are capable of facilitating persistent expression of a transgene which is delivered by the vector to a cell. The vectors are E1/partial E3 deleted vectors which contain a transgene operably linked to expression control sequences
5981275 Transgene expression system for increased persistence November 9, 1999
The invention is directed to a transgene expression system comprising a transcription unit which contains a transgene operably linked to expression control sequences, preferably the CMV promoter, and which is delivered simultaneously with all or part of the adenovirus E4 genomic regi
5882877 Adenoviral vectors for gene therapy containing deletions in the adenoviral genome March 16, 1999
Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide
5877011 Chimeric adenoviral vectors March 2, 1999
A chimeric adenoviral vector is provided that comprises nucleotide sequence of a first adenovirus, wherein at least one gene of said first adenovirus encoding a protein that facilitates binding of said vector to a target mammalian cell, or internalization thereof within said cell, is rep










 
 
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