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Inventor: Goschke; Richard
Address: Bottmingen, CH
No. of patents: 33
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 5705658 |
Azido containing tetrahydro furan compounds |
January 6, 1998 |
| .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients. |
| 5659065 |
Alpha-aminoalkanoic acids and reduction products |
August 19, 1997 |
| Compounds of formula I ##STR1## wherein R.sub.1 is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or heteroaromatic radical, a hydroxy group that is aliphatically, araliphatically or heteroarylaliphatically etherified or protected by a hydroxy-protecting group, |
| 5654445 |
.delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acids |
August 5, 1997 |
| .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients. |
| 5646143 |
.delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides |
July 8, 1997 |
| .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## |
| 5641778 |
Aromatically substituted .omega.-amino-alkanoic acid amides and alkanoic acid diamides |
June 24, 1997 |
| Compounds of formula I ##STR1## wherein R.sub.1 is a 2-R.sub.A -3-R.sub.B -phenyl radical, a 2-R.sub.A -4-R.sub.C -phenyl radical, a 2-R.sub.A -pyridin-3-yl radical, a 3-R.sub.A -pyridin-2-yl radical or a 1-R.sub.D -indol-3-yl radical, wherein one of the radicals R.sub.A and R.su |
| 5627182 |
.delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides |
May 6, 1997 |
| .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients. |
| 5606078 |
3,5-Disubstituted tetrahydrofuran-2-ones |
February 25, 1997 |
| Compounds of formula I ##STR1## wherein R.sub.1 is free or esterified carboxy, hydroxymethyl or formyl,R.sub.2 and R.sub.4 are each independently of the other aliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radicals andR.sub.3 is azido, or amino that is aliphatica |
| 5559111 |
.delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides |
September 24, 1996 |
| .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients. |
| 4914129 |
Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups |
April 3, 1990 |
| Compounds of the formula ##STR1## in which R.sub.1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated .alpha.-amino acid residue that is bonded N-terminally to R.sub.1 and C-terminally to the group --NR.sub.2 --, R.sub.2 re |
| 4889869 |
Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups |
December 26, 1989 |
| Compounds of the formula ##STR1## in which R.sub.1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated .alpha.-amino acid residue that is bonded N-terminally to R.sub.1 and C-terminally to the group --NR.sub.2 --, R.sub.2 re |
| 4758584 |
Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups |
July 19, 1988 |
| Compounds of the formula ##STR1## in which R.sub.1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated .alpha.-amino acid residue that is bonded N-terminally to R.sub.1 and C-terminally to the group --NR.sub.2 --, R.sub.2 re |
| 4727060 |
Novel 5-amino-4-hydroxyvaleryl derivatives |
February 23, 1988 |
| Compounds of the formula ##STR1## in which R.sub.1 represents hydrogen or acyl, A represents an optionally N-alkylated .alpha.-amino acid residue which is bonded N-terminally to R.sub.1 and C-terminally to the group --NR.sub.2 --, R.sub.2 represents hydrogen or lower alkyl, R.sub |
| 4704391 |
Pyridazinones, and pharmaceutical preparations thereof |
November 3, 1987 |
| The invention concerns compounds of formula I ##STR1## wherein R is a fluorine, bromine or iodine atom or the amino, acetylamino, methyl, cyano, hydroxyl, methoxy or trifluoromethyl group, the tautomeric forms thereof, and acid addition salts of the compounds in which R represent |
| 4699908 |
Alkyl substituted pyridazinones and pharmaceutical compositions |
October 13, 1987 |
| The present invention relates to novel 6-phenyl-5-alkyl substituted-4,5-dihydro-3(2H)-pyridazinones of formula I: ##STR1## in which R.sub.1 is halogen, lower alkyl, lower alkoxy, NO.sub.2, NH.sub.2, NHCOR.sub.3 (R.sub.3 is H or C.sub.1 -C.sub.4 alkyl), CN, carboxy, lower alkoxyca |
| 4654340 |
Pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof |
March 31, 1987 |
| The invention concerns compounds of formula I ##STR1## wherein R is a fluorine, bromine or iodine atom or the amino, acetylamino, methyl, cyano, hydroxyl, methoxy or trifluoromethyl group, the tautomeric forms thereof, and acid addition salts of the compounds in which R represent |
| 4629789 |
Alkyl substituted pyridazinones and pharmaceutical compositions |
December 16, 1986 |
| The present invention relates to novel 6-phenyl-5-alkyl substituted-4,5-dihydro-3(2H)-pyridazinones of formula I: ##STR1## in which R.sub.1 is halogen, lower alkyl, lower alkoxy, NO.sub.2, NH.sub.2, NHCOR.sub.3 (R.sub.3 is H or C.sub.1 -C.sub.4 alkyl), CN, carboxy, lower alkoxyca |
| 4624951 |
Substituted pyridazinones, pharmaceutical preparations containing these compounds, and the use t |
November 25, 1986 |
| The present invention relates to novel substituted pyridazinones of the general formula I ##STR1## wherein R is a halogen atom, a lower alkyl or lower alkoxy group, the nitro, hydroxyl, cyano, carboxyl, lower alkoxycarbonyl or carbamoyl group or the trifluoromethyl group, and Z i |
| 4613599 |
Method of treating thrombotic disease with pyridazinones |
September 23, 1986 |
| The invention concerns compounds of formula I ##STR1## wherein R is a fluorine, bromine or iodine atom or the amino, acetylamino, methyl, cyano, hydroxyl, methoxy or trifluoromethyl group, the tautomeric forms thereof, and acid addition salts of the compounds in which R represent |
| 4608382 |
2-(Sulphinyl and sulfonyl)-4(5)-phenyl-5(4)-(3'-pyridyl)-imidazols |
August 26, 1986 |
| Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or |
| 4584310 |
Novel mercaptoimidazole derivatives |
April 22, 1986 |
| Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or |
| 4476132 |
Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic re |
October 9, 1984 |
| Quinolinone derivatives of the formula (I) ##STR1## in which X represents oxy or a direct bond, R.sub.1 represents an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical or hydrogen, Ph represents an optionally additionally substituted |
| 4461770 |
Mercaptoimidazole derivatives |
July 24, 1984 |
| Novel substituted 2-mercaptoimidazoles of the formula ##STR1## in which at least one of the radicals R.sub.1 and R.sub.2 is a substituted or unsubstituted heteroaryl group and the other is a substituted or unsubstituted aryl group, R.sub.3 is hydrogen or lower alkyl, n is 0, 1 or |
| 4451471 |
Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods |
May 29, 1984 |
| 2,4,5-Trisubstituted thiazoles of the formula ##STR1## in which each of R.sub.1 and R.sub.2, independently of the other, represents an aryl or optionally N-oxidized heteroaryl radical each of which is unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherifie |
| 4396621 |
Certain 2-oxo-2,3-dihydro-3-benzothiophene-carboxamides and their pharmaceutical compositions |
August 2, 1983 |
| Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 |
| 4353918 |
Dextrorotatory bicyclic thiadiaza compounds and pharmaceutical preparations containing them |
October 12, 1982 |
| The invention relates to the dextrorotatory enantiomer of trans-5,6-di-p-methoxyphenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and its pharmaceutically acceptable salts and to pharmaceutical preparations containing them.The new compounds have valuable pharmacological properties, especia |
| 4320138 |
Oxothia compounds |
March 16, 1982 |
| Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 |
| 4308277 |
2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same |
December 29, 1981 |
| Compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 independently of one another are substituted or unsubstituted aryl or hetero-aryl groups, R.sub.3 is hydrogen or lower alkyl and R.sub.4 is a substituted or unsubstituted aliphatic hydrocarbon radical, and their pharm |
| 4296128 |
Carboxylic acid hydrazides and processes for their manufacture |
October 20, 1981 |
| New carboxylic acid hydrazides of the formula ##STR1## in which R represents an optionally esterified carboxy group,and salts of the compound of the formula I, in which R represents carboxy, possess antithrombotic properties and can be used as medicinal active substances in pharmaceu |
| 4263455 |
Novel 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones |
April 21, 1981 |
| The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower |
| 4260779 |
Oxothia compounds |
April 7, 1981 |
| Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 d |
| 4192873 |
Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones |
March 11, 1980 |
| The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower |
| 4185110 |
Certain benzofuryl or benzothienyl-2-glyoxylic acid compounds |
January 22, 1980 |
| Novel benzoheterocyclylglyoxylic acid derivatives of the formula ##STR1## in which Z is free, etherified or acylated hydroxyl, X is thio or oxy, R is free or etherified hydroxyl, R.sub.1 is lower alkyl, cycloalkyl, hydroxyl, lower alkoxy, substituted or unsubstituted phenoxy, substit |
| 3973022 |
Quinolineacetic acid compositions |
August 3, 1976 |
| Compounds of the formula ##SPC1##Wherein Ar denotes an optionally substituted phenyl group or hetero-aromatic group with 5 or 6 ring members wherein the atom directly bonded to the quinoline ring is a carbon atom, R.sub.1 represents hydrogen, halogen, lower alkyl, lower alkoxy or tri |
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