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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Gold; Elijah H.
Address:
West Orange, NJ
No. of patents:
42
Patents:












Patent Number Title Of Patent Date Issued
5348944 Carboxyalkyl dipeptides September 20, 1994
Compounds of the formula ##STR1## useful as antihypertensive agents are disclosed.
5302716 Fused benzazepines April 12, 1994
Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.
4996202 1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof February 26, 1991
Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described.
4973586 Fused benzazepines, compositions of, and medical use thereof November 27, 1990
Disclosed are fused benzazepine compounds, pharmaceutical compositions including such compounds, methods of using such compounds, for example, in the treatment of psychoses and/or depression, and intermediates useful in the preparation of such compounds.
4950783 Treatment of hypertension August 21, 1990
Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.
4853476 Phosphorus containing compounds as inhibitors of enkephalinases August 1, 1989
Novel phosphorous containing compounds and compositions containing said compounds inhibit the actions of enkephalinases in mammals. Methods for preparing said compounds and compositions and methods for their use to elicit analgesia and treat mental disorders are described.Useful intermed
4840772 Antiglaucoma compositions and methods June 20, 1989
The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treat
4831157 Preparation of angiotensin-converting enzyme inhibitors May 16, 1989
Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma. Also disclosed is a novel proce
4818749 Carboxyalkyl dipeptides and medical use thereof in treating hypertension and congestive heart fa April 4, 1989
The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure.The compounds of the present invention are compounds of the formulae ##STR1## and
4808573 Carboxyalkyl dipeptides and anti-hypertensive use thereof February 28, 1989
The present invention relates to carboxyalkyl dipeptides which are inhibitors of angiotensin-converting enzyme and are useful as antihypertensive agents and in the treatment of congestive heart failure.The compounds of the present invention are compounds of the formulae ##STR1## and
4783444 Antiglaucoma compositions and methods November 8, 1988
The present invention relates to ophthalmological pharmaceutical compositions comprising (benzothiadiazine, benzamide and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds and to methods for using said composition in reducing intraocular pressure, e.g., in the treat
4691049 Process for preparing a specific diastereomer of a monoamino dicarboxylic acid ester September 1, 1987
(Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds are disclosed. Compounds of this invention are useful as antihypertensive agents.
4619919 Treatment of hypertension October 28, 1986
Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.
4587258 Angiotensin-converting enzyme inhibitors May 6, 1986
Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma.
4584285 Antihypertensive agents April 22, 1986
(Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds are disclosed. Compounds of this invention are useful as antihypertensive agents.
4477378 Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines October 16, 1984
Disclosed are esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepines represented by the general formula I ##STR1## wherein X is chloro, bromo or trifluoromethyl; R.sub.1 is alkyl, aralkyl, aryl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, cycloalkylalkyl,
4470972 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids September 11, 1984
This invention relates to 7-carboxyalkyl-aminoacyl-1,4-adithia-7-azaspiro[4.4]nonane-8-carboxylic acids. The compounds of the invention are useful in the treatment of cardiovascular disorders and especially as antihypertensive agents.
4468400 Antiulcer tricyclic imidazo [1,2-a]pyridines August 28, 1984
There are disclosed certain substituted tricyclic imidazo[1,2-a]pyridines which are useful in the treatment of peptic ulcer diseases.
4379166 Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols April 5, 1983
This invention relates to 5-(2-alkylamino-1-hydroxyethyl)salicylamides and 4-(2-alkylamino-1-hydroxyethyl)-2-(methylsulfinyl)phenols wherein the alkyl group is substituted by arylmethoxy, arylmethylthio, heteroarylmethoxy, or heteroarylmethylthio, pharmaceutical compositions thereof,
4349472 (S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4, 5-tetrahydro-1H-3-benzazepine September 14, 1982
This invention relates to esters of 7 halo-substituted 8-hydroxy-3 methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, processes for the preparation thereof, and pharmaceutical compositions containing them. The novel compounds of this invention show neuroleptic, antidepressive and
4340597 1-Substituted-4-aryl-1,2,5,6-tetrahydro and hexahydropyridines July 20, 1982
Disclosed herein are certain 1-substituted-4-aryl-1,2,5,6-tetrahydro and hexahydro triazolo pyridines which are useful as analgesics.
4322434 N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto March 30, 1982
N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto, useful as antihypertensive agents, are prepared by reaction of an N-substituted aniline with a polyfluoroacetone.
4312863 Treatment of glaucoma January 26, 1982
Ophthalmic compositions containing (-)-5-{(R)-1-Hydroxy- 2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamide and a method of using them in the treatment of glaucoma are disclosed.
4304790 2-(Alkylthio, alkylsulfinyl or alkylsulfonyl)-4-[2-anilinoalkylamino)-1-hydroxyethyl]phenols and December 8, 1981
2-(Alkylthio, alkylsulfinyl or alkylsulfonyl)-4-[2-(anilinoalkylamino)-1-hydroxyalkyl]phenols and derivatives thereof, particularly useful as agents for the treatment of hypertension, are disclosed herein.
4299845 Dermatological compositions and methods of use therefor November 10, 1981
The present invention relates to topical compositions and methods of use utilizing compounds of the formula ##STR1## wherein X is oxygen or sulfur;W is a bridge group of the formulae ##STR2## wherein R is hydrogen alkyl of 1 to 7 carbon atoms, cycloalkyl of 4-8 carbon atoms,
4284555 7-Chloro-8(substituted amino carbonyloxy)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines August 18, 1981
This invention relates to substituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. The compounds of this invention show neuroleptic, antidepressive and antiagressive activity.
4272550 Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids June 9, 1981
Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with a
4267193 N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto May 12, 1981
N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto, useful as antihypertensive agents, are prepared by reaction of an N-substituted aniline with a polyfluoroacetone.
4199597 Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio)alkanoic acids April 22, 1980
Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with a
4196124 1-Benzhydryl-2-benzimidoyl-azetidine April 1, 1980
1-Benzhydryl-2-benzimidoyl-azetidine, an intermediate useful in the preparation of novel N-diphenylalkyl-2-benzyl azacyclic compounds which can be used as antiobesity agents, is disclosed.
4183923 Antipsoriatic compositions January 15, 1980
Disclosed herein are compositions containing 1-substituted-3-alkanesulfonyloxyazetidines, useful in the treatment of psoriasis.
4173583 Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide November 6, 1979
Disclosed is an improved process for separating 5-[1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl]salicylamide into its two diastereoisomeric racemates; a process for converting either diastereoisomer into the other; and the use of one specified diastereoisomer as a superior antiarr
4173566 1-Benzhydryl-2-cyanoazetidine November 6, 1979
1-benzhydryl-2-cyanoazetidine is a novel intermediate for the synthesis of N-diphenylalkyl-2-benzyl azacyclic compounds.
4163053 Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides July 31, 1979
5-[2-(Substituted-anilinoalkylamino)-1-hydroxyalkyl]-salicylamides, particularly useful as agents for the treatment of hypertension, are disclosed herein.
4140780 Pharmaceutical compositions comprising N-diphenylalkyl-2-benzyl azacyclic compounds and methods February 20, 1979
N-diphenylalkyl-2-benzyl azacyclic compounds and pharmaceutical compositions thereof which are useful as antiobesity agents are disclosed herein. Some of these compounds also exhibit useful antimicrobial properties. Additionally, novel chemical intermediates for the synthesis of this
4088644 N-Acyl-3-azetidinone May 9, 1978
Disclosed herein are novel N-acyl-3-aryl-3-azetidinols useful as intermediates. A method is provided for their direct preparation from acyclic starting materials. These N-acyl-3-aryl-azetidinols provide a convenient route to the 3-azetidinol series.
4052383 N-diphenylalkyl-2-benzyl azacyclic compounds October 4, 1977
Novel N-diphenylalkyl-2-benzyl azacyclic compounds are disclosed which can be used as antiobesity agents. Some of these compounds also exhibit useful antimicrobial properties. Additionally, novel chemical intermediates for the synthesis of this series are provided.
3987182 Novel benzimidazoles useful as anti-androgens October 19, 1976
Disclosed herein are chemical compounds identifiable as substituted 2-alkylbenzimidazoles particularly useful as anti-androgens.
3965176 Novel substituted amidines June 22, 1976
This application relates to substituted amidines, to methods for their preparation and to methods for their use as anti-androgenic agents.
3965175 Poultry coccidiosis treating compositions and method of using the same June 22, 1976
Poultry coccidiosis is treated with certain malonanilides.
3956390 Preparation of amines May 11, 1976
A process is provided for the preparation of amines via the desulfonylation of sulfonamides by means of sodium bis-(2-methoxyethoxy) aluminum hydride.
3941885 Compositions useful for treating parkinsonism March 2, 1976
Disclosed herein are compounds of the formula: ##EQU1## wherein Ad is 1-adamantyl; R is H or CH.sub.3 ; X is COOM or CH.sub.2 ##EQU2## wherein M is H or a pharmaceutically acceptable cation, and R.sub.1 is lower n-alkyl; and the pharmaceutically acceptable salts thereof.Preferred










 
 
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