| Patent Number |
Title Of Patent |
Date Issued |
| 5057621 |
11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
October 15, 1991 |
| This invention covers a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, Y is lower alkyl or ##STR2## wh |
| 4792617 |
11-substituted-16-phenoxy and 16-substituted phenoxy-prostatrienioc acid derivatives |
December 20, 1988 |
| This invention covers a compound of the formula ##STR1## wherein R is hydrogen, lower alkyl or a pharmaceutically acceptable, non-toxic salt of a compound wherein R is hydrogen; X is hydrogen, halo, trifluoromethyl, lower alkyl or lower alkoxy, Y is lower alkyl or ##STR2## wh |
| 4761416 |
N-N-disubstituted-.omega.-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides an |
August 2, 1988 |
| Pharmaceutical compositions comprising, or compositions consisting essentially of, compounds according to the formula ##STR1## or an optical isomer thereof are disclosed, wherein the substituents A, Z and R.sup.1 are defined herein. The invention is also directed to certain compo |
| 4690925 |
(2-Oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl) oxyalkylamides properties having phosphodi |
September 1, 1987 |
| Compounds according to the formula ##STR1## , its optical isomers, or a pharmaceutically acceptable salt thereof wherein:m and n are integers of 1 to 6;R.sub.1 is hydrogen or alkyl of 1 to 4 carbons;R.sub.2 is hydrogen or R.sub.1 and R.sub.2 are combined to form an oxo group;R.sub.3 |
| 4323564 |
Esters of 6-chloro-11.beta., 17.alpha.,21-trihydroxypregna-1,4,6-triene-3,20-dione |
April 6, 1982 |
| The 17-butyrate, 17-benzoate, 17,21-methyl orthobutyrate, 17,21-methyl orthobenzoate, and 17,21-dibutyrate esters of cloprednol (6-chloro-11.beta., 17.alpha., 21-trihydroxy-pregna-1,4,6-triene-3,20-dione) are useful as topical, anti-inflammatory steroids. |
| 4207241 |
2-Naphthyl acetic acid derivatives and compositions and methods thereof |
June 10, 1980 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 4097674 |
2-Naphthylacetic acid derivatives |
June 27, 1978 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 4080461 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
March 21, 1978 |
| Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SO.sub.2 R.sup.2, --SCN, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 where M and M' a |
| 4072696 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
February 7, 1978 |
| Carbalkoxythioureidobenzene derivatives represented by the following formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SR.sup.2, --SOR.sup.2, --SO.sub.2 R.sup.2, --OR.sup.2, --SCN, --SC(O)NR.sup.3 R.sup.4, or --M'(CH.sub.2).sub.n MR.sup.7 w |
| 4051233 |
2-Naphthylacetic acid derivatives and compositions and methods thereof |
September 27, 1977 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 4048330 |
Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating infla |
September 13, 1977 |
| Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid derivatives substituted at the 2-position of the acetic acid moiety with methyl, ethyl, difluoromethyl, or methylene, and the salts and esters thereof, having anti-inflammatory, analgesic and anti-pyretic activities, a |
| 4046801 |
13-Cis prostaglandin derivatives |
September 6, 1977 |
| 13-Cis prostaglandin derivatives; cis-octenol ether copper.sup.(I) lithium reagents and methods of making such reagents and using the reagents to prepare the 13-cis prostaglandin derivatives. The 13-cis prostaglandin derivatives exhibit prostaglandin-like pharmacological properties and a |
| 4045485 |
Naphthyl acetaldehyde derivatives; methods of use thereof; and processes for the preparation the |
August 30, 1977 |
| 2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity. |
| 4031234 |
1,5(6)-Disubstituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
June 21, 1977 |
| This application relates to 1,5(6)-disubstituted benzimidazole-2-carbamate derivatives represented by the following formula: ##STR1## where R is lower alkyl having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 ; R.sup.2 is lower |
| 4011320 |
7(8)-Substituted triazinobenzimidazoles and anthelmintic compositions and method |
March 8, 1977 |
| 7(8)-substituted triazinobenzimidazoles represented by the formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R' is diloweralkylaminoalkyl (C.sub.2-6) or alkyl having 1 to 18 carbon atoms; R.sup.2 is phenylsulfinyl, phenoxyethoxy, benzyloxyethoxy, methox |
| 4009197 |
2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof |
February 22, 1977 |
| 2-(6'-Substituted-2'-naphthyl)acetic acid derivatives substituted at the 2-position of the acetic acid moiety with methyl, methylene or halomethylene and the salts and esters thereof have anti-inflammatory, analgesic and anti-pyretic activities. |
| 4005202 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
January 25, 1977 |
| Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is a heterocyclic ring having 1-4 hetero atoms; and M is O, S, or ##STR2## The R.sup.1 M-substitution is at th |
| 4002640 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
January 11, 1977 |
| Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##STR1## where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is -SOR.sup.2, -SO.sub.2 R.sup.2, -SCN, -SR.sup.5, -OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 where M and M' are in |
| 4001301 |
6-Substituted 2-naphthyl acetic acid derivatives |
January 4, 1977 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 4001295 |
11,12-Difluoromethylene substituted prostanoic and prost-5-cis-enoic acid derivatives |
January 4, 1977 |
| Novel racemic and antimeric prostaglandin analogs having a difluoromethylene group attached to the C-11,12 positions of the molecule, and oxygenated functions at C-9 and C-15, which may be further substituted at C-15 by a methyl group and processes for the production of such compound |
| 3998966 |
Anti-inflammatory, analgesic, anti-pyretic and anti-pruritic 6-substituted 2-naphthyl acetic aci |
December 21, 1976 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 3993769 |
1,5(6)-Disubstituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
November 23, 1976 |
| This application relates to 1,5(6)-disubstituted benzimidazole-2-carbamate derivatives represented by the following formula: ##SPC1##Where R is lower alkyl having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 ; R.sup.2 is lower alk |
| 3993768 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
November 23, 1976 |
| This application describes further species embraced by the following generic formula: ##SPC1##Where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SOR.sup.2, --SO.sub.2 R.sup.2, --SCN, --SR.sup.5, --OR.sup.5 or M'(CH.sub.2).sub.n MR.sup.7 where M and M' are indepen |
| 3989721 |
Disubstituted xanthone carboxylic acid compounds |
November 2, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3989720 |
Disubstituted xanthone carboxylic acid compounds |
November 2, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3988352 |
Disubstituted xanthone carboxylic acid compounds |
October 26, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3985791 |
16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
October 12, 1976 |
| Novel racemic and 8R-antimeric 16-phenoxy- and 16-(o, m or p)-substituted phenoxy derivatives of 9.alpha., 11.alpha.,15-trihydroxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acids, which may be further substituted at C-15 by a methyl or ethyl group, the pharmaceutically accepta |
| 3980699 |
2-Naphthyl acetic acid derivatives |
September 14, 1976 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 3979458 |
Production of unsaturated carbocyclic ketones |
September 7, 1976 |
| Preparation of .alpha.,.beta.-unsaturated carbocyclic ketones by reacting an enol lactone with a carbanion generated by treatment of a methylphosphonate or a mono-substituted methylphosphonate with base. |
| 3979414 |
Disubstituted xanthone carboxylic acid compounds |
September 7, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3978124 |
6-Substituted 2-naphthyl .alpha.-substituted acetamides |
August 31, 1976 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 3978116 |
2-Naphthyl acetic acid derivatives and compositions and methods thereof |
August 31, 1976 |
| 2-Naphthyl acetic acid derivatives and the corresponding amides, esters, hydroxamic acids and addition salts thereof, optionally substituted at the .alpha.-position on the acetic acid moiety and/or at position 6 and/or at positions 1, 4, 7 or 8 on the naphthyl ring and optionally saturat |
| 3970684 |
Polyunsaturated prostaglandin derivatives |
July 20, 1976 |
| Novel prostaglandin dehydro analogs of the PGA and PGB series and the 9-hydroxy-derivatives thereof, which possess a diethylenic unsaturation in the carboxylic acid chain and may be additionally substituted at C-4, C-6, C-9 and/or C-15 by a methyl, ethyl or propyl group, as well as the |
| 3969412 |
16,17-Seco-delta 4,9(10) and -delta 4,9(10),11 steroids |
July 13, 1976 |
| The novel 16,17-secoestra-4,9(10)-diene, 16,17-secoestra-4,9(10),11-triene, 16,17-secogona-4,9(10)-diene and 16,17-secogona-4,9(10)-triene compounds and the 14.beta.-isomers thereof useful as antiandrogenic agents, and methods for their preparation. |
| 3965115 |
Disubstituted xanthone carboxylic acid compounds |
June 22, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3965113 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
June 22, 1976 |
| Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##SPC1##Where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is --SR.sup.5 or --OR.sup.5 ; and R.sup.5 is aryl. The R.sup.1 substitution is at the 5(6)-position.The compounds are |
| 3963753 |
Disubstituted xanthone carboxylic acid compounds |
June 15, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3963752 |
Disubstituted xanthone carboxylic acid compounds |
June 15, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3960936 |
Naphthyl substituted aliphatic acids |
June 1, 1976 |
| 2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity. |
| 3958012 |
D 2-(6-Substituted-2-naphthyl)-propanals |
May 18, 1976 |
| The d 2-(6-substituted-2-naphthyl)propanals of this invention are prepared by oxidizing the corresponding 2-(6-substituted-2-naphthyl)-1-propanols or by reducing d 2-(6-substituted-2-naphthyl)propionic acids, the 6-substituent being a methyl, ethyl, isopropyl, cyclopropyl, trifluorom |
| 3951618 |
Method of use of, and compositions containing, disubstituted xanthone carboxylic acid compounds |
April 20, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel disubstituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed |
| 3949084 |
Novel substituted xanthone carboxylic acid compounds |
April 6, 1976 |
| Compositions containing and methods employing, as the essential ingredient, novel substituted xanthone carboxylic acid compounds which are useful in the treatment of allergic conditions. Methods for preparing these compounds and compositions and intermediates therein are also disclosed. |
| 3947472 |
Naphthyl acetaldehyde derivatives |
March 30, 1976 |
| 2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity. |
| 3940407 |
.beta.-Adrenergic blocking agents in the 1,2,3-thiadiazole series |
February 24, 1976 |
| Novel 4-[2,3 or 4(3-amino-2-hydroxypropoxy) phenyl]- and 5-[2,3 or 4(3-amino-2-hydroxypropoxy) phenyl]-1,2,3-thiadiazole derivatives which may be further substituted at the C-5 or C-4 position of the thiadiazole ring, respectively, by a lower alkyl, phenyl, trifluoromethyl, carboxy, |
| 3935273 |
Naphthyl acetaldehyde derivatives |
January 27, 1976 |
| 2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity. |
| 3935209 |
5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
January 27, 1976 |
| Benzene ring substituted benzimidazole-2-carbamate derivatives represented by the formula: ##SPC1##Where R is a lower alkyl group having 1 to 4 carbon atoms; R.sup.1 is a heterocyclic ring having 1-4 hetero atoms; and M is O, S, or ##EQU1## The R.sup.1 M-substitution is at the 5( |
