Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Frei; Jorg
Address:
Holstein, CH
No. of patents:
25
Patents:












Patent Number Title Of Patent Date Issued
6710047 Phthalazines with angiogenesis inhibiting activity March 23, 2004
The invention relates to compounds of formula I, ##STR1##wherein r is 0 to 2, n is 0 to 2; m is 0 to 4; R.sub.1 and R.sub.2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I* ##STR2##or (iii) together form a bridge in subformula I** ##STR3##wherei
6514974 Pyrido-, pyrimido-, pyridazo- and pyrazo- pyridazines having angiogenesis inhibiting activity February 4, 2003
The invention relates to compounds of formula I, ##STR1##wherein r is 0 to 2, n is 0 to 2; m is 0 to 4; R.sub.1 and R.sub.2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I* ##STR2##or (iii) together form a bridge in subformula I** ##STR3##wherei
6258812 Phthalazines with angiogenesis inhibiting activity July 10, 2001
The invention relates to compounds of formula I, ##STR1##wherein r is 0 to 2, n is 0 to 2; m is 0 to 4; R.sub.1 and R.sub.2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I* ##STR2##(I*) or (iii) together form a bridge in subformula I** ##STR3##(
6251911 Pyrimidine derivatives and processes for the preparation thereof June 26, 2001
4-Amino-1H-pyrazolo[3,4-d]pyrimidine derivatives of formula I ##STR1##wherein the substituents are as defined in claim 1, are described.These compounds inhibit the tyrosine kinase activity of the receptor for epidermal growth factor (EGF) and c-erbB2 kinase and can be used as anti-tumor
6180636 Substituted pyrrolopyrimidines and processes for their preparation January 30, 2001
There are described 7H-pyrrolo[2,3-d]pyrimidine derivatives of the formula I ##STR1##in which the substituents are as defined in claim 1.These compounds inhibit the tyrosine kinase activity of the receptor for the epidermal growth factor (EGF) and c-erbB2 kinase and can be used as an
6140332 Pyrrolopyrimidines and processes for the preparation thereof October 31, 2000
Described are 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula I ##STR1## wherein the symbols are as defined in claim 1. Those compounds inhibit tyrosine protein kinase and can be used in the treatment of hyperproliferative diseases, for example tumour diseases.
6140317 Pyrrolopyrimidines and processes for their preparation October 31, 2000
There are described compounds of formula I ##STR1## wherein R.sub.1 and R.sub.2 are as defined in the description, Q is heterocyclyl boned via a ring nitrogen atom and having the formula IA ##STR2## wherein R.sub.3 and R.sub.4 and m and n are as defined in the description, th
5981533 Pyrazole derivatives and processes for the preparation thereof November 9, 1999
4-Amino-1H-pyrazolo[3,4-d]pyrimidine derivatives of formula I ##STR1## wherein the symbols are as defined in claim 1, and intermediates for their manufacture are described.The compounds of formula I inhibit especially the tyrosine kinase activity of the receptor for epidermal growth
5840911 Imidazole derivatives, their preparation and their use as S-adenosylmethionine decarboxylase (=S November 24, 1998
Described are compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy;R.sub.2, R.sub.2 ' and R.sub.2 " are each independently of the others hydrogen or a substituent other than hydrogen;eitherR.sub.3 is hydrogen or a substituent other than hydrogen andR.sub.4 is hydrogen o
5834486 Piperidinyl-2-alkyl, substituted linear polyamines for the reduction of intracellular, endogenic November 10, 1998
The invention relates to compounds of formula (I) ##STR1## wherein either R.sub.1 is hydrogen andR.sub.2 is lower alkyl lower alkenyl or lower alkynyl,m is 3 or 4 andn is 2 or 3;orR.sub.1 and R.sub.2 together are tetrainethylene,m is 3 or 4 andn is 2;or salts thereof.The compounds of formula
5639911 Hydrazones June 17, 1997
Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
5627215 Unsaturate amino compounds for use as anticancer and antiprotozoic agent May 6, 1997
The invention relates to compounds of formula (I), R.sub.1 and R.sub.2, each independently of the other, are selected from lower alkyl that is unsubstituted or substituted by one or more fluorine atoms which are not linked to the carbon atom of R.sub.1 or R.sub.2 bonding the nitrogen; fr
5610195 Ornithine decarboxylase inhibiting branched aminooxy amino alkane derivatives March 11, 1997
Compounds of formula (I) in which (a) four of the radicals R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen and the others independently of one another are in each case C.sub.1 -C.sub.2 alkyl, these groups being bonded to the same carbon atom or to two different c
5516806 Ornithine decarboxylase inhibiting cyclic aminooxy compounds May 14, 1996
Compounds of formula (I): H.sub.2 N--(CH.sub.2).sub.n --A--(CH.sub.2).sub.m --O--NH.sub.2 and salts thereof are described in which the radical A is C.sub.3 -C.sub.6 cycloalkylene; n is 0 or 1 and, independently thereof, m is 0 or 1; with the provisos that a) the distance between the amin
5395855 Hydrazones March 7, 1995
Compounds of formula I ##STR1## wherein A, X, Z and R.sub.1 -R.sub.5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
5376685 Arylhydrazones using as SAMDC inhibitors December 27, 1994
Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
5354761 Bipyridyls October 11, 1994
Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a manner known per se.
5322852 Aminooxy piperidines as ornithine decarboxylase inhibitors June 21, 1994
The invention relates to compounds of formula I ##STR1## wherein either R.sub.1 is a radical of formula Ia,in which n is 0 or 1, is hydrogen and R.sub.2 is a radical of formula Ib,in which p is 1 or 2, and wherein R is C.sub.1 -C.sub.2 alkyl which is attached to one carbon atom of the ce
5238941 Arylhydrazones and pharmaceutical compositions thereof August 24, 1993
Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
5169867 Hydroxylamine compounds December 8, 1992
Compounds of formula ##STR1## wherein R.sub.1 is amino or is a radical ##STR2## wherein R.sub.3 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, carboxy, lower alkoxycarbonyl, phenyl, phenyl substituted by lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, halo
5118709 Arylhydrazones and pharmaceutical compositions containing the same June 2, 1992
Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.
5064832 Biaryl compounds November 12, 1991
Compounds of formula I ##STR1## wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, Y, Z and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are especially active against tumors. They are prepared in a manner known per se.
4971986 Arylhydrazones useful as SAMDC inhibitors November 20, 1990
Compounds of formula I ##STR1## wherein A, X.sub.1, X.sub.2, X.sub.3, X.sub.4, Y, Z and R.sub.1 to R.sub.6 have the meanings given in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.
4968804 Bipyridine compounds November 6, 1990
Compounds of formula I ##STR1## wherein X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5, X.sub.6, Y, Z and R.sub.1 -R.sub.4 are as defined in the description, have valuable pharmaceutical properties and are especially active against tumours. They are prepared in a manner known per se
4342764 Guanidine compounds, pharmaceutical compositions and use August 3, 1982
The invention relates to guanidine derivatives, particularly to substituted guanidines of the formula ##STR1## having hypoglycaemic activity, for the oral treatment of hyperglycaemia in mammals, especially for the oral treatment of Diabetes mellitus.










 
 
  Recently Added Patents
Image forming unit having agitating portion and image forming apparatus
Chemical method of making a suspension, emulsion or dispersion of pyrithione particles
Provision of downlink packet access services to user equipment in spread spectrum communication network
Image browsing device, computer control method and information recording medium
Group of amino substituted benzoyl derivatives and their preparation and their use
Semiconductor device having a bonding pad and shield structure of different thickness
Passive millimeter wave differential interference contrast polarimetry
  Randomly Featured Patents
Magnetic material, and a MEMS device using the magnetic material
Method and means for measuring guidance errors at one or more points along the length of a displacement-measuring system
Sampling apparatus and method for sampling
Front door of motor vehicle
Composite semipermeable membrane created by precipitation of emulsion polymers onto base film microporous surfaces
Method for making sucker rod oil well pump
Fuel/air mixing device for jet engines
Ion exchange regeneration method
Battery side terminal extender
Seismic cable locator