| Patent Number |
Title Of Patent |
Date Issued |
| RE38981 |
DNA sequence coding for protein C |
February 14, 2006 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| RE37958 |
DNA sequence coding for protein C |
January 7, 2003 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| 7541449 |
Human kunitz-type inhibitors and methods relating thereto |
June 2, 2009 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked t |
| 7122342 |
Protease-activated receptor PAR4 (ZCHEMR2) |
October 17, 2006 |
| The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease |
| 6656746 |
Antibodies to human kunitz-type inhibitor |
December 2, 2003 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to |
| 6436400 |
Protease-activated receptor PAR4 ZCHEMR2 |
August 20, 2002 |
| The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease |
| 6111075 |
Protese-activated receptor PAR4 (ZCHEMR2) |
August 29, 2000 |
| The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease |
| 6080406 |
Hematopoietic cytokine receptor |
June 27, 2000 |
| Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells a |
| 6025176 |
Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
February 15, 2000 |
| Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specifi |
| 5989537 |
Methods for stimulating granulocyte/macrophage lineage using thrombopoietin |
November 23, 1999 |
| Methods for stimulating granulocyte/macrophage lineage cells using thrombopoiet in are provided. The methods provided may be used to stimulate granulocyte/macrophage progenitors and neutrophils in bone marrow and peripheral blood cells and in vitro and in vivo. In addition, methods f |
| 5935854 |
Human amyloid protein precursor homolog and kunitz-type inhibitor |
August 10, 1999 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor |
| 5925735 |
Hematopoietic cytokine receptor |
July 20, 1999 |
| Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells a |
| 5919635 |
Method of detecting glucagon receptor antagonists |
July 6, 1999 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first |
| 5914315 |
Human Kunitz-type inhibitors and compositions thereof |
June 22, 1999 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein first DNA segment is operably linked to add |
| 5905185 |
Protein C production in non-human transgenic mammals |
May 18, 1999 |
| Methods for producing protein C in transgenic non-human mammals are disclosed. The protein C is modified at the two-chain cleavage site between the light and heavy chains of protein C from Lys-Arg to R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 where R.sub.1 through R.sub.4 are individually Ar |
| 5792850 |
Hematopoietic cytokine receptor |
August 11, 1998 |
| Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular ligand-binding domain of a cell-surface receptor that is expressed at high levels in lymphoid tissue, including B-cells a |
| 5792620 |
Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
August 11, 1998 |
| Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specifi |
| 5776725 |
Recombinant production of glucagon receptors |
July 7, 1998 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first |
| 5770445 |
Glucagon receptor proteins, peptides, and antibodies |
June 23, 1998 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first |
| 5766921 |
Hybrid protein C |
June 16, 1998 |
| Human protein C molecules are modified to provide increased resistance to inactivation by human plasma factors while retaining substantially the biological activity of human protein C. The modifications are generally to the heavy chain of protein C, which chain may be substituted with a |
| 5753224 |
Hybrid protein C |
May 19, 1998 |
| Human protein C molecules are modified to provide increased resistance to inactivation by human plasma factors while retaining substantially the biological activity of human protein C. The modifications are generally to the heavy chain of protein C, which chain may be substituted with a |
| 5728674 |
Inhibition of blood coagulation by human-kunitz-type inhibitors |
March 17, 1998 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to |
| 5677146 |
Human amyloid protein precursor homolog and kunitz-type inhibitor |
October 14, 1997 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor |
| 5641655 |
Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator |
June 24, 1997 |
| DNA constructs useful in the production of thrombopoietin are disclosed. In general, the DNA constructs comprise a first DNA segment encoding a fusion of an amino-terminal secretory peptide joined to a thrombopoietin polypeptide and one or more additional DNA segments that provide for th |
| 5639940 |
Production of fibrinogen in transgenic animals |
June 17, 1997 |
| Materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding A.alpha., B.beta. and .gamma. chains of fibrinogen are introduced into the germ line of a non-human mammal, and the mammal or its female progeny produces milk containing |
| 5618696 |
Human kunitz-type protease inhibitor and variants thereof |
April 8, 1997 |
| The present invention relates to a human Kunitz-type protease inhibitor comprising the following amino acid sequenceor a variant thereof with protease inhibitor properties. |
| 5527692 |
Methods for producing thrombin |
June 18, 1996 |
| Methods are disclosed for producing thrombin. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. The DNA constructs generally include the following operably linked elem |
| 5516650 |
Production of activated protein C |
May 14, 1996 |
| Methods are disclosed for producing a protein which has substantially the same biological activity as human protein C or human activated protein C. The protein is produced by mammalian host cells transfected with a plasmid capable of integration in mammalian host cell DNA. The plasmid in |
| 5504001 |
Hybrid plasminogen activator |
April 2, 1996 |
| Hybrid proteins comprising a cross-linking domain derived from a protein that acts as an acyl-donor substrate for factor XIIIa, a fibrin-binding domain, and a serine protease domain are disclosed. Host cells transfected or transformed with an expression vector comprising a transcriptiona |
| 5502034 |
Methods for producing thrombin |
March 26, 1996 |
| Methods are disclosed for producing thrombin. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. The DNA constructs generally include the following operably linked elem |
| 5476777 |
Methods for producing thrombin |
December 19, 1995 |
| Methods are disclosed for producing thrombin. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. The DNA constructs generally include the following operably linked elem |
| 5455338 |
DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
October 3, 1995 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to |
| 5441931 |
Human amyloid protein precursor homologue and Kunitz-type inhibitors |
August 15, 1995 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor |
| 5436153 |
Human amyloid protein precursor homolog and Kunitz-type inhibitor |
July 25, 1995 |
| The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homolog and Kunitz-type inhibitor. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homolog or a |
| 5358932 |
Hybrid protein C |
October 25, 1994 |
| Human protein C molecules are modified to provide increased resistance to inactivation by human plasma factors while retaining substantially the biological activity of human protein C. The modifications are generally to the heavy chain of protein C, which chain may be substituted with a |
| 5302529 |
Plasmid coding for human protein C |
April 12, 1994 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| 5225537 |
Methods for producing hybrid phospholipid-binding proteins |
July 6, 1993 |
| Methods are disclosed for producing hybrid phospholipid-binding proteins from eukaryotic cells. DNA constructs comprising a transcriptional promoter, at least one signal sequence and a hybrid phospholipid-binding protein coding sequence comprising at least one lipocortin lipid-binding |
| 5200340 |
Thrombin-activated tissue plasminogen activators |
April 6, 1993 |
| Zymogens of proteins having fibrinolytic activity are disclosed. The proteins are cleavable by thrombin, the cleavage resulting in the stimulation of fibrinolytic activity. Suitable proteins which may be modified in accordance with the present invention include tissue plasminogen act |
| 5073609 |
DNA sequence coding for protein C |
December 17, 1991 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| 4968626 |
DNA sequence coding for protein C |
November 6, 1990 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed. |
| 4959318 |
Expression of protein C |
September 25, 1990 |
| Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C and recombinant transfer vectors comprising these sequences are disclosed.Methods are disclosed for producing a protein which has substantially the same biological activit |
