| Patent Number |
Title Of Patent |
Date Issued |
| 7601499 |
Paired end sequencing |
October 13, 2009 |
| The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the invention provides cloning and DNA manipulation strategies to isolate the two ends of a |
| 7553619 |
Detection method using dissociated rolling circle amplification |
June 30, 2009 |
| Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a DNA circle with the analyte and subsequent release and rolling circle replication of the circular DNA molecule. In the method, an amplificati |
| 6887664 |
Asynchronous primed PCR |
May 3, 2005 |
| An asynchronous thermal cycling protocol for nucleic acid amplification uses two primers with thermal melting temperatures different by about 10 to 30.degree. C. After the higher melting primer has annealed and polymerase mediated extension, the uncopied, single-stranded target seque |
| 6787310 |
Strand displacement methods employing competitor oligonucleotides for isolating one strand of a |
September 7, 2004 |
| The present invention provides methods and kits for isolating one strand of a double-stranded target nucleic acid. The method capitalizes on the differences in the kinetics and thermodynamic stabilities between conventional DNA/DNA, DNA/RNA and RNA/RNA duplexes and heteroduplexes in |
| 6469151 |
PNA-DNA chimeric probe arrays and methods of use |
October 22, 2002 |
| The invention provides methods, kits, and compositions for ligation of PNA-DNA chimeric probes and oligonucleotides when they are hybridized adjacently to template nucleic acids using ligases and ligation reagents. Structural requirements of the chimeras for ligation include 5 to 15 |
