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Inventor:
Dolfini; Joseph E.
Address:
Cincinnati, OH
No. of patents:
28
Patents:




Patent Number Title Of Patent Date Issued
4927805 Hydrolysis of curcumin May 22, 1990
Curcumin is subjected to the action of heat and pressure in the presence of water by a continuous or batch process to produce vanillin and other natural flavor products. The proportion of vanillin in the final product varies with the pH of the reaction mixture.
4871881 Hydrolysis of activated olefinic ketones and aldehydes October 3, 1989
Ketones or aldehydes containing one or more carbon-carbon double bonds and a carbonyl group conjugated with at least one double bond are hydrolyzed by the action of heat and pressure in the presence of water by a batch or continuous process. The ketone or aldehyde cleaves at the double b
4810824 Hydrolysis of activated olefinic ketones and aldehydes March 7, 1989
Ketones or aldehydes containing one or more carbon-carbon double bonds and a carbonyl group conjugated with at least one double bond are hydrolyzed by the action of heat and pressure in the presence of water by a batch or continuous process. The ketone or aldehyde cleaves at the double b
4766249 Method of catalytically hydrolyzing alpha, beta-unsaturated carbonyl compounds August 23, 1988
Alpha, beta-unsaturated carbonyl compounds are hydrolyzed under alkaline conditions in the presence of water to produce additional carbonyl-containing compounds. High yields are obtained when the alkaline catalyst contains hydroxide ion and the pH is maintained in the range of about
4709098 Hydrolysis of activated olefinic ketones and aldehydes November 24, 1987
Ketones or aldehydes containing one or more carbon-carbon double bonds and a carbonyl group conjugated with at least one double bond are hydrolyzed by the action of heat and pressure in the presence of water. The ketone or aldehyde cleaves at the double bond conjugated with the carbonyl
4673766 Method of producing benzaldehyde June 16, 1987
A method is disclosed for producing benzaldehyde by fractionally steam distilling benzaldehyde from cinnamaldehyde in the presence of hydroxide catalyst and at a pH on the order of about 11 to about 13. Conversions of cinnamaldehyde to benzaldehyde can be achieved on the order of about 7
4302581 7-(1,3-Dithiolan-2-imino)cephalosporanic acid derivatives November 24, 1981
Novel 7-(1,3-dithiolan-2-imino)cephalosporin derivatives are described which are particularly useful for their antibacterial properties.
4291160 7-(1,3-Dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives September 22, 1981
Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties.
4285958 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof August 25, 1981
Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole
4285957 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof August 25, 1981
Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, -
4254130 Piperidine derivatives March 3, 1981
Pharmaceutically useful compounds of the following formula: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is a positive whole
4254129 Piperidine derivatives March 3, 1981
Novel compounds of the following formula: ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.3, -
4244955 2,4a-Ethanobenz[g]isoquinolin-5(1H)-ones and their use as anti-fertility and analgesic agents January 13, 1981
2,4a-Ethanobenz[g]isoquinolin-5(1H)-one derivatives are described which are useful as analgesic and anti-fertility agents.
4208516 7-(1,3-Dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives June 17, 1980
Novel 7-(1,3-dithiolan-2-imino)-.DELTA..sup.2 -cephalosporanic acid derivatives are described which possess useful antibacterial properties.
4206305 7-(1,3-Dithiolan-2-imino)cephalosporanic acid derivatives June 3, 1980
Novel 7-(1,3-dithiolan-2-imino)cephalosporin derivatives are described which are particularly useful for their antibacterial properties.
4206119 6-(1,3-Dithiolan-2-imino)penicillanic acid derivatives June 3, 1980
Novel 6-(1,3-dithiolan-2-imino)penicillanic acid derivatives are described which are particularly useful for their antibacterial properties.
4172941 7-[2-[.omega.-(1,3-Dit hiolan-2-imino)substituted]-acetylamino]cephalosporanic acid derivatives October 30, 1979
Novel 7-[2-[.omega.-(1,3-dithiolan-2-imino)substituted]-acetylamino]cephalospora nic acid derivatives are described having useful antibacterial activity.
4131683 .omega.-(1,3-Dithiolan-2-imino) substituted acetic acids December 26, 1978
.omega.-(1,3-Dithiolan-2-imino) substituted acetic acids are prepared useful as antibacterial agents, inhibitors of cholesterol and fatty acid synthesis, anti-inflammatory agents and as intermediates for cephalosporin antibiotics.
4062842 Method for preparing 7-substituted cephalosporins and 6-substituted penicillins by replacement o December 13, 1977
Disclosed is a method for replacing 7-lower alkylthio and 7-arylthio groups from cephalosporins with lower alkanoyloxy,lower alkoxy, aryloxy, aroyloxy, amino, lower alkylamino and azido moieties, and for replacing 6-lower alkylthio and 6-arylthio groups from penicillins with lower al
4061629 6-Amino-6-arylthio penicillanic acids and derivatives thereof December 6, 1977
6-Amino and 6-benzalimino-6-arylthio penicillins are disclosed. These compounds are useful as intermediates in the preparation of 6-acylamino-6-arylthio penicillins.
4060630 Ethylenediamine derivatives useful in treating sickle cell anemia November 29, 1977
Compounds of the following general formula are useful in the treatment of sickle cell anemia: ##STR1## WHEREIN EACH OF R and R.sub.1 is hydrogen, chlorine, fluorine, bromine, trifluoromethyl, hydroxy, a lower alkoxy group of from 1 to 4 carbon atoms or a straight or branched lowe
4039537 Thio-.beta.-lactam cephalosporins August 2, 1977
Thio-.beta.-lactam cephalosporins of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R.sub.1 is hydrogen, lower alkyl, cycloalkyl, phenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic
4029669 6-Benzalimino-6-arylthio penicillanic acids and derivatives thereof June 14, 1977
6-Amino and 6-benzalimino-6-arylthio penicillins are disclosed. These compounds are useful as intermediates in the preparation of 6-acylamino-6-arylthio penicillins.
4018761 Thio-.beta.-lactam cephalosporins April 19, 1977
New intermediates of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal and X is lower alkylthiadiazolylthio or lower alkyltetrazolylthio are useful for the production of antimicrobially active acyl deri
4018760 Thio-.beta.-lactam cephalosporins April 19, 1977
Thio-.beta.-lactam cephalosporins of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R.sub.1 is hydrogen, lower alkyl, cycloalkyl, phenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic
3971780 Thio-.beta.-lactam cephalosporins July 27, 1976
Thio-.beta.-lactam cephalosporins of the general formula ##SPC1##Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R.sub.1 is hydrogen, lower alkyl, cycloalkyl, phenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic group
3971776 Thio-.beta.-lactam penicillins July 27, 1976
Thio-.beta.-lactam penicillins of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R.sub.1 is hydrogen, lower alkyl, cycloalkyl, phenyl, lower alkoxyphenyl, phenoxy, phenyl-lower alkyl or cert
3944544 Bis-cephalosporins March 16, 1976
Derivatives of difunctional compounds such as dicarboxylic acids, diisocyanates or diisothiocyanates wherein each functional group is reacted with 7-aminocephalosporanic acid or 7-aminodesacetoxycephalosporanic acid possess antibacterial activity.


 
 
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