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Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inventor:
Devadas; Balekudru
Address:
Chesterfield, MO
No. of patents:
57
Patents:


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Patent Number Title Of Patent Date Issued
8563558 Substituted pyridine urea compounds October 22, 2013
The present disclosure provides pyridine urea compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, V and W are as defi
7629363 Diaryl substituted pyridinones December 8, 2009
Disclosed are compounds Formula I ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, R.sub.3/R.sub.4, and R.sub.5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kin
7339078 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors March 4, 2008
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
7161033 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors January 9, 2007
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
7141594 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors November 28, 2006
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to se
7138411 Substituted benzopyran derivatives for the treatment of inflammation November 21, 2006
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR00001## wherein X, A.sup.1, A.sup.2, A.sup.3, A
7119098 Heteroarylakanoic acids as intergrin receptor antagonists October 10, 2006
The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the .alpha..nu..beta..sub.3 and/or the .alpha..nu..
7109211 Substituted benzopyran derivatives for the treatment of inflammation September 19, 2006
A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR00001## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R'', R.sup.1 and R.sup.2 are as described in the specifi
7098202 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors August 29, 2006
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds,
7067540 Substituted pyridinones June 27, 2006
Disclosed are compounds Formula I ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kin
7045518 Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors May 16, 2006
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected no
6998415 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors February 14, 2006
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6933304 Heteroarylalkanoic acids as integrin receptor antagonists August 23, 2005
The present invention relates to a class of compounds represented by the Formula I ##STR1##or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the .alpha..sub.V.beta..sub.3 and/or th
6921767 Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives July 26, 2005
The present invention relates to a class of compounds represented by the Formula I ##STR1##or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v.beta..s
6906051 Lactone integrin antagonists June 14, 2005
The present invention relates to a class of compounds represented by the Formula I: ##STR1##or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.V.beta..
6875785 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhib April 5, 2005
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6861539 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors March 1, 2005
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
6806288 Substituted benzopyran derivatives for the treatment October 19, 2004
A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1##wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specification.
6753344 Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibit June 22, 2004
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6730669 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors May 4, 2004
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds,
6720327 Lactone integrin antagonists April 13, 2004
The present invention relates to a class of compounds represented by the Formula I. ##STR1##or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v.beta..
6696477 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhib February 24, 2004
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I
6689754 Heterocyclic glycyl .beta.-alanine derivatives February 10, 2004
The present invention relates to a class of compounds represented by the Formula I ##STR1##or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the .alpha..sub.v.beta..sub.3 integrin.
6683210 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors January 27, 2004
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
6677364 Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors January 13, 2004
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6673822 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors January 6, 2004
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to se
6667307 Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors December 23, 2003
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected no
6531494 Gem-substituted .alpha.v.beta.3 antagonists March 11, 2003
The present invention relates to a class of compounds represented by the Formula I. ##STR1##or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.V.beta..
6515014 Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibit February 4, 2003
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6512121 Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhib January 28, 2003
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6492390 Substituted benzopyran analogs for the treatment of inflammation December 10, 2002
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1##wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4
6458785 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors October 1, 2002
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compo
6432999 Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibito August 13, 2002
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
6407134 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors June 18, 2002
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to se
6388132 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors May 14, 2002
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
6380188 Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors April 30, 2002
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected no
6316496 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors November 13, 2001
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
6310080 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors October 30, 2001
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds,
6271253 Substituted benzopyran derivatives for the treatment of inflammation August 7, 2001
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1##wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4
6214861 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors April 10, 2001
Selected heterocycle carbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to s
6169085 Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors January 2, 2001
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected no
6150556 Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors November 21, 2000
Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel com
6100423 Amino benzenepropanoic acid compounds and derivatives thereof August 8, 2000
The present invention is directed to compounds of the formula ##STR1## where R.sup.1 is BOC or H, R is H or lower alkyl; X and Y are the same or different halo atoms selected from the group consisting of Cl, Br or I and pharmaceutically acceptable salts and isomers thereof.
6077850 Substituted benzopyran analogs for the treatment of inflammation June 20, 2000
A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R",
6063795 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors May 16, 2000
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to se
6034256 Substituted benzopyran derivatives for the treatment of inflammation March 7, 2000
A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A.sup.1, A.sup.2, A.sup.3, A.sup.4, R, R", R.sup.1 and R.sup.2 are as described in the specifica
5985870 Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors November 16, 1999
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected no
5972989 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors October 26, 1999
Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to se
5968970 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors October 19, 1999
Described herein is a retroviral protease inhibiting compound of the formula: ##STR1## or a pharmaceutically acceptable salt, prodrug or ester thereof.
5965601 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors October 12, 1999
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds,
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