| Patent Number |
Title Of Patent |
Date Issued |
| 5862999 |
Method of grinding pharmaceutical substances |
January 26, 1999 |
| A method of preparing submicron particles of a therapeutic or diagnostic agent which comprises grinding the agent in the presence of grinding media having a mean particle size of less than about 75 microns. In a preferred embodiment, the grinding media is a polymeric resin. The method pr |
| 5718388 |
Continuous method of grinding pharmaceutical substances |
February 17, 1998 |
| A continuous method of preparing submicron particles of a therapeutic or diagnostic agent comprises the steps of continuously introducing the agent and rigid grinding media into a milling chamber, contacting the agent with the grinding media while in the chamber to reduce the particle si |
| 5609998 |
Process for dispersing concentrated aqueous slurries |
March 11, 1997 |
| A process for dispersing a particulate solid substance in a continuos aqueous phase comprising the steps of:providing a comminution reactor;providing a particulate solid substance comprising a weak acid functional group, having effective pK.sub.a1 >1 and less than 1% by weight aqueous |
| 5605785 |
Annealing processes for nanocrystallization of amorphous dispersions |
February 25, 1997 |
| A process for forming a nanocrystalline dispersion of a photographically useful compound in a continuous phase comprising the steps of:providing a nanoamorphous dispersion of said photographically useful compound in said continuous phase, andannealing said nanoamorphous dispersion to transfo |
| 5513803 |
Continuous media recirculation milling process |
May 7, 1996 |
| A continuous method of preparing submicron particles of a compound useful in imaging elements (or other materials, such as pigments, etc.) comprises the steps of continuously introducing the compound and rigid milling media into a milling chamber, contacting the compound with the milling |
| 5500331 |
Comminution with small particle milling media |
March 19, 1996 |
| A method of preparing submicron particles of a material, such as a pigment useful in paints or a compound useful in imaging elements, which comprises milling the agent in the presence of milling media having a mean particle size of less than about 100 microns. In a preferred embodiment, |
| 5478705 |
Milling a compound useful in imaging elements using polymeric milling media |
December 26, 1995 |
| Particles of compound useful in imaging elements are milled using a milling media comprising a polymeric resin. The use of polymeric milling media permits the production of particles having an average particle size less than 1 micron. Further, the resulting particles are free from the |
| 5411715 |
Apparatus for preparing aqueous amorphous particle dispersions of high-melting microcrystalline |
May 2, 1995 |
| An apparatus for producing amorphous particle dispersions of high-melting microcrystalline solids in a continuous process. The apparatus comprises a pump, two heat exchangers, a back-pressure valve and conduits connecting them, whereby it is possible to make aqueous dispersions of partic |
| 5338345 |
Water-based water repellent coating compositions |
August 16, 1994 |
| There is provided a water based water repellent coating composition, method of making and method of use. The coating composition comprises an emulsion having water as the continuous phase and, as the discontinuous phase, droplets of a nonvolatile organic water repellent composition, the |
| 5298386 |
In-line solvent incorporation for amorphous particle dispersions |
March 29, 1994 |
| An in-line process for mixing solvents with amorphous particle dispersions is disclosed. Continuous emulsification of the solvent is achieved by an in-line high-shear mixer, and diffusion of solvent to the amorphous particles is controlled in a plug flow reactor. Both processes are c |
| 5145684 |
Surface modified drug nanoparticles |
September 8, 1992 |
| Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and d |
| 5110717 |
Stability improvement of amorphous particle dispersions |
May 5, 1992 |
| An object of the invention is to overcome disadvantages of prior practices. A further object of the invention is to provide a process for providing particles that result in improved UV absorption in photographic products.An additional object is to provide lower cost polymer particle dispersi |
