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Inventor:
Craighead; Harold G.
Address:
Ithaca, NY
No. of patents:
48
Patents:












Patent Number Title Of Patent Date Issued
8293337 Multiplexed electrospray deposition method October 23, 2012
Multiplexed electrospray deposition apparatus capable of delivering picoliter volumes of one or more substances is disclosed. The apparatus may include a unitary planar dispenser etched from a silicon wafer through microfabrication or micromachining technology. The apparatus may be u
8174352 Method for making a transducer, transducer made therefrom, and applications thereof May 8, 2012
A method for manufacturing or preparing thin-film stacks that exhibit moderate, finite, stress-dependent resistance and which can be incorporated into a transduction mechanism that enables simple, effective signal to be read out from a micro- or nano-mechanical structure. As the stru
8106580 Electrospun light-emitting fibers January 31, 2012
The invention teaches electrospun light-emitting fibers made from ionic transition metal complexes ("iTMCs") such as [Ru(bpy).sub.3].sup.2+(PF.sub.6.).sup.2]/PEO mixtures with dimensions in the 10.0 nm to 5.0 micron range and capable of highly localized light emission at low operatin
8072117 Thermal-mechanical signal processing December 6, 2011
A source signal is converted into a time-variant temperature field with transduction into mechanical motion. In one embodiment, the conversion of a source signal into the time-variant temperature field is provided by utilizing a micro-fabricated fast response, bolometer-type radio fr
8049580 MEMS controlled oscillator November 1, 2011
An array of micromechanical oscillators have different resonant frequencies based on their geometries. In one embodiment, a micromechanical oscillator has a resonant frequency defined by an effective spring constant that is modified by application of heat. In one embodiment, the osci
7943307 Methods for analyzing nucleic acid sequences May 17, 2011
The present invention is directed to a method of sequencing a target nucleic acid. The method provides a complex comprising a polymerase enzyme, a target nucleic acid molecule, and a primer, wherein the complex is immobilized on a support Fluorescent label is attached to a terminal p
7943305 High speed nucleic acid sequencing May 17, 2011
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid. Each type of labeled nucleotide
7942568 Active micromixer using surface acoustic wave streaming May 17, 2011
An active micromixer uses a surface acoustic wave, preferably a Rayleigh wave, propagating on a piezoelectric substrate to induce acoustic streaming in a fluid in a microfluidic channel. The surface acoustic wave can be generated by applying an RF excitation signal to at least one in
7939273 High sensitivity mechanical resonant sensor May 10, 2011
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first res
7918979 Entropic trapping and sieving of molecules April 5, 2011
Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially small
7843283 MEMS controlled oscillator November 30, 2010
An array of micromechanical oscillators have different resonant frequencies based on their geometries. In one embodiment, a micromechanical oscillator has a resonant frequency defined by an effective spring constant that is modified by application of heat. In one embodiment, the osci
7833398 Length-dependent recoil separation of long molecules November 16, 2010
Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor sub
7812502 Shell type actuator October 12, 2010
A micromechanical resonator is formed on a substrate. The resonator has a partial spherical shell clamped on an outside portion of the shell to the substrate. In other embodiments, a flat disc or other shape may be used. Movement is induced in a selected portion of the disc, inducing eas
7781378 Protective coating for array material deposition August 24, 2010
An array is formed with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate. Desired material is deposited on the substrate through the openings. The protective cover may then be removed. In one embodiment, the protective
7695988 Quantum dot conjugates in a sub-micrometer fluidic channel April 13, 2010
A nanofluidic channel fabricated in fused silica with an approximately 500 nm square cross section was used to isolate, detect and identify individual quantum dot conjugates. The channel enables the rapid detection of every fluorescent entity in solution. A laser of selected waveleng
7691583 High sensitivity mechanical resonant sensor April 6, 2010
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first res
7654140 Heat pumped parametric MEMS device February 2, 2010
A micro-electrical mechanical oscillator has a resonant frequency of oscillation that is varied by application of heat. The resonant frequency is varied at a frequency different from the resonant frequency of the oscillator to amplify oscillations. In one embodiment, the oscillator is
7537807 Scanned source oriented nanofiber formation May 26, 2009
Nanofibers are formed using electrospray deposition from microfluidic source. The source is brought close to a surface, and scanned in one embodiment to form oriented or patterned fibers. In one embodiment, the surface has features, such as trenches on a silicon wafer. In further emb
7485424 Labeled nucleotide phosphate (NP) probes February 3, 2009
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7473361 Diffusion-based molecular separation in structured microfluidic devices January 6, 2009
A microfluidic device has features that reduce the speed of flow of higher speed diffusing molecules. The features are used to separate various components of a mixture in the microfluidic device. The channel is sized to ensure laminar flow of the mixture to promote only diffusive mixing
7427343 Entropic trapping and sieving of molecules September 23, 2008
Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially small
7416844 Composition for nucleic acid sequencing August 26, 2008
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7409851 Detection of small bound mass August 12, 2008
Prefabricated catalyzing adsorption sites are incorporated into small oscillators. In one embodiment, the sites are formed of precisely positioned gold anchors on surface micromachined oscillators. The micromachined oscillators may be formed of silicon, such as polysilicon, or silico
7405434 Quantum dot conjugates in a sub-micrometer fluidic channel July 29, 2008
A nanofluidic channel fabricated in fused silica with an approximately 500 nm square cross section was used to isolate, detect and identify individual quantum dot conjugates. The channel enables the rapid detection of every fluorescent entity in solution. A laser of selected waveleng
7361466 Nucleic acid analysis using terminal-phosphate-labeled nucleotides April 22, 2008
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7358822 MEMS oscillator drive April 15, 2008
The temperature of a remote portion of device having a microelectromechanical oscillator is modulated to create oscillation of the oscillators. In one embodiment, a localized heat source is placed on a device layer of a multilayered stack, consisting of device, sacrificial and substr
7316769 Length-dependent recoil separation of long molecules January 8, 2008
Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor sub
7292742 Waveguides for performing enzymatic reactions November 6, 2007
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequenc
7267797 Nanofabricated photon tunneling based sensor September 11, 2007
A system and method for detecting changes in the refractive index of a fluid in a small test volume. A change in the refractive index can indicate a change in the chemical composition of the fluid. The test volume has a depth comparable to or less than the wavelength of incident ligh
7181122 Zero-mode waveguides February 20, 2007
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequenc
7148017 High sensitivity mechanical resonant sensor December 12, 2006
A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first res
7105810 Electrospray emitter for microfluidic channel September 12, 2006
An electrospray ionization device incorporates a shaped thin film with a microfluidic channel. The device may be interfaced to a time-of-flight mass spectrometer (TFOMS). In one embodiment, the shaped thin film has a polygonal-shaped or triangle-shaped thin polymer tip formed by lith
7081622 Electrospray emitter for microfluidic channel July 25, 2006
An electrospray ionization device incorporates a shaped thin film with a microfluidic channel. The device may be interfaced to a time-of-flight mass spectrometer (TFOMS). In one embodiment, the shaped thin film has a polygonal-shaped or triangle-shaped thin polymer tip formed by lith
7056676 Method for sequencing nucleic acid molecules June 6, 2006
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7056661 Method for sequencing nucleic acid molecules June 6, 2006
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7052847 Method for sequencing nucleic acid molecules May 30, 2006
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7033764 Method for sequencing nucleic acid molecules April 25, 2006
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic
7013054 Waveguides for performing spectroscopy with confined effective observation volumes March 14, 2006
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequenc
6917726 Zero-mode clad waveguides for performing spectroscopy with confined effective observation volume July 12, 2005
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency le
6900575 Multiple mechanical resonator parametric device May 31, 2005
A resonator device utilizes two small mechanical resonators that are electrostatically coupled. A first resonator receives an input signal near its resonant frequency, and the input signal and a second signal are summed and provided to a second resonator. The resonant frequency of the
6753200 Monolithic nanofluid sieving structures for DNA manipulation June 22, 2004
A new technique for fabricating two-dimensional and three-dimensional fluid microchannels for molecular studies includes fabricating a monolithic unit using planar processing techniques adapted from semiconductor electronics fabrication. A fluid gap between a floor layer (12) and a ceili
6743570 Method of using heat-depolymerizable polycarbonate sacrificial layer to create nano-fluidic devi June 1, 2004
A polycarbonate polymer such as poly(cyclohexene carbonate) acts as a positive electron beam resist, is substantially transparent to ultra violet light and that depolymerizes when heated. The polymer acts as a positive electron beam resist at 5 kV, and depolymerizes at temperatures b
6635163 Entropic trapping and sieving of molecules October 21, 2003
Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller t
6559474 Method for topographical patterning of materials May 6, 2003
A method of patterning a preselected material on a substrate is provided, comprising coating a substrate surface with a releasable polymer coating, creating one or more openings through the polymer coating to expose a portion of the substrate surface in a predefined pattern, coating at l
6515751 Mechanically resonant nanostructures February 4, 2003
Electron beam lithography is used to make very small mechanical structures in single-crystal silicon. The structure may be a mesh having beam widths of less than 30 nm and suspended in a wafer, above a substrate. An rf drive voltage applied between the suspended structure and the underly
6438279 Unitary microcapiliary and waveguide structure and method of fabrication August 20, 2002
Fabrication techniques for forming arbitrarily shaped fluid capillaries at dimensions below 1 .mu.m and for forming optical waveguides in the same devices with the same fabrication processes include methods to make integral optical waveguide/fluid-flow systems for greater miniaturization
6214246 Multiple optical channels for chemical analysis April 10, 2001
Apparatus for optical analysis of a sample material includes a channel block incorporating microfabricated channels and an integral gel material. Illuminating optics direct light to the sample material and light reflected from, refracted by and/or emitted by the sample is collected by
5867266 Multiple optical channels for chemical analysis February 2, 1999
Apparatus for optical analysis of a sample material includes a channel block incorporating microfabricated channels and an integral gel material. Illuminating optics direct light to the sample material and light reflected from, refracted by and/or emitted by the sample is collected by










 
 
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