| Patent Number |
Title Of Patent |
Date Issued |
| 6426182 |
Apparatus and method for determining whether formaldehyde in aqueous solution has been neutraliz |
July 30, 2002 |
| A test device, method, and indicators for the colorimetric determination of formaldehyde neutralization in an aqueous solution initially containing formaldehyde are provided. Formaldehyde is neutralized by reaction with sulfite ion, where the sulfite ion is provided by dissolving a s |
| 5420016 |
Test device and kit for detecting helicobacter pylori |
May 30, 1995 |
| A rapid method and easy to use unitized test device is disclosed for determining the presence of Helicobacter pylori in a biological tissue specimen by detecting the presence of urease in the tissue. The system basically utilizes a multilayer test device for separating and optimizing |
| 5314804 |
Test for Helicobacter pylori |
May 24, 1994 |
| A rapid method and easy to use unitized test device is disclosed for determining the presence of Helicobacter pylori in a biological tissue specimen by detecting the presence of urease in the tissue. The system basically utilizes a multilayer test device for separating and optimizing |
| 5200313 |
Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
April 6, 1993 |
| A nucleic acid hybridization assay employing an immobilized or immobilizable polynucleotide probe selected to form DNA.RNA or RNA.RNA hybrids with the particular polynucleotide sequence to be determined. Resulting hybrids are detected by binding of an antibody reagent, preferably lab |
| 4833084 |
Monoclonal antibody specific for DNA.RNA hybrids |
May 23, 1989 |
| A monoclonal antibody specific for DNA.multidot.RNA duplexes, particularly DNA.multidot.RNA heteropolymer duplexes, characterized by having cross-reactivity for binding to single- or double-stranded DNA or RNA as measured by competitive immunoassay of less than about 1:1000, and pref |
| 4806631 |
Immobilization of nucleic acids on solvolyzed nylon supports |
February 21, 1989 |
| Immobilization of nucleic acids, e.g., DNA and RNA, by contact with a solid support comprising nylon whose amide groups have been partially solvolyzed. Solvolysis of the nylon support can be accomplished by treatment with an alkylating agent such as a trialkyloxonium salt under anhyd |
| 4806546 |
Immobilization of nucleic acids on derivatized nylon supports |
February 21, 1989 |
| Immobilization of nucleic acids, e.g., DNA and RNA, by contact with a solid support comprising nylon having amide groups that have been derivatized to amidine residues. Derivatization of the nylon support can be accomplished by treatment with an alkylating agent such as a trialkyloxonium |
| 4743535 |
Hybridization assay employing labeled probe and anti-hybrid |
May 10, 1988 |
| A nucleic acid hybridization assay involving a labeled probe and formation of a hybrid having epitopes for an antibody reagent. The label provides a detectable response which is measurably different when the labeled probe is comprised in a hybrid that is bound by the antibody reagent com |
| 4472301 |
Propranolol immunogen and antibodies |
September 18, 1984 |
| A propranolol immunogen comprising an unsubstituted hydroxypropylamine precursor of propranolol coupled through a bis-imidate linking group to an immunogenic carrier material. The immunogen is useful to stimulate the production of antibodies which recognize propranolol and can perform as |
| 4468469 |
Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays |
August 28, 1984 |
| An improved immunoassay method, reagent means, and test kit for determining an iodothyronine, e.g., thyroxine (T-4), in a biological fluid, usually serum or plasma, wherein fenclofenac and related phenylacetic acids, or salts thereof, are employed as novel blocking agents for the binding |
| 4404366 |
Beta-galactosyl-umbelliferone-labeled hapten conjugates |
September 13, 1983 |
| An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula:wherein G is a glycone, D is a dye indicator moiety, and R is a linking group through which the label residue |
| 4399121 |
Iodothyronine immunogens and antibodies |
August 16, 1983 |
| Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates. |
| 4363759 |
Chemiluminescent-labeled haptens and antigens |
December 14, 1982 |
| Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 is hydrogen and the other is -NR.sup.3 R.sup.4 ; R.sup.3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R.sup.4 is ##STR2## wherein n=1-3 and L(CO-- is the lig |
| 4358604 |
N-Aminoalkyl iodothyronine derivatives |
November 9, 1982 |
| N-Aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, immunogen conjugates comprising the derivatives coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates. |
| 4355165 |
Amino-functionalized phthalhydrazide intermediates |
October 19, 1982 |
| Amino-functionalized phthalhydrazide intermediates of the formula: ##STR1## wherein one of R.sup.5 and R.sup.6 is hydrogen and the other is --NR.sup.7 R.sup.8 ; R.sup.7 is hydrogen or straight chain alkyl containing 1-4 carbon atoms and R.sup.8 is ##STR2## wherein n=1-3. The |
| 4331590 |
.beta.-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates |
May 25, 1982 |
| An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula:wherein G is a glycone, D is a dye indicator moiety, and R is a linking group through which the label residue |
| 4279992 |
Specific binding assay employing an enzyme-cleavable substrate as label |
July 21, 1981 |
| An improved specific binding assay method and reagent for determining a ligand in a liquid medium employing, as an enzyme-cleavable substrate label, a residue having the formula:wherein G is a glycone, D is a dye indicator moiety, and R is a linking group through which the label residue |
| 4261893 |
Bis-phthalimide intermediates |
April 14, 1981 |
| Bis-phthalimide intermediates of the formula: ##STR1## wherein one of R.sup.9 and R.sup.10 is hydrogen and the other is --NR.sup.11 R.sup.12 ; R.sup.11 is hydrogen or straight stain alkyl containing 1-4 carbon atoms and R.sup.12 is ##STR2## wherein n=1-3. The compounds are in |
| 4259233 |
.beta.-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates |
March 31, 1981 |
| A .beta.-galactosyl-umbelliferone-labeled conjugate of the formula: ##STR1## wherein --NH)L is a protein or polypeptide, such as an immunoglobulin, bound through an amino group thereof, n is an integer from 2 through 10, m is an integer from 1 through 10, and p is on the average from |
| 4259232 |
Flavin adenine dinucleotide-labeled protein and polypeptide conjugates |
March 31, 1981 |
| Flavin adenine dinucleotide-labeled conjugates of the formula: ##STR1## wherein Riboflavin--Phos).sub.2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide (FAD), --NH)L is a protein or polypeptide (e.g., an immunoglobulin) bound through a |
| 4255566 |
Flavin adenine dinucleotide derivatives and labeled conjugates prepared therefrom |
March 10, 1981 |
| A flavin adenine dinucleotide (FAD) derivative of the formula: ##STR1## wherein n is an integer from 2 through 10, and preferably is 6. The derivatives are intermediates in the preparation of FAD-labeled conjugates useful as reagents in specific binding assays for determining ligands |
| 4238195 |
Fluorescer-labeled specific binding assays |
December 9, 1980 |
| A specific binding assay method and reagent means for determining a ligand, such as an antigen or antibody, in, or the ligand binding capacity of, a liquid medium which employs a fluorescent substance, i.e., a fluorescer, as a label. The improvement comprises measuring the fluorescer-lab |
| 4226978 |
.beta.-Galactosyl-umbelliferone-labeled aminoglycoside antibiotics and intermediates in their pr |
October 7, 1980 |
| .beta.-Galactosyl-umbelliferone labeled aminoglycoside antibiotics, e.g., gentamicin, useful in homogeneous and heterogeneous specific binding assays for such antibiotics in liquid media such as serum. Also provided are a .beta.-galactosyl-umbelliferone-carboxylic acid and salts thereof |
| 4213893 |
Flavin adenine dinucleotide-labeled conjugates for use in specific binding assays |
July 22, 1980 |
| Labeled conjugates of the formula: ##STR1## wherein Riboflavin--Phos).sub.2 Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide (FAD), n=2 through 6, and --CO)L is a specifically bindable ligand, or a binding analog thereof, and is prefera |
| 4171432 |
Flavin adenine dinucleotide-iodothyronine conjugates |
October 16, 1979 |
| Conjugates of the formula: ##STR1## wherein Riboflavin-(Phos).sub.2 -Ribose represents the riboflavin-pyrophosphate-ribose residue in flavin adenine dinucleotide (FAD), n equals 2 through 6, Y is hydrogen or trifluoroacetyl, and .beta..sup.1 and .beta..sup.2 are, independently, h |
| 4134792 |
Specific binding assay with an enzyme modulator as a labeling substance |
January 16, 1979 |
| A specific binding assay method employing, as a labeling substance, a reversibly binding enzyme modulator for the detection of a ligand in a liquid medium. The method follows conventional specific binding assay techniques of either the homogeneous or heterogeneous type wherein the li |
