| Patent Number |
Title Of Patent |
Date Issued |
| 7138524 |
Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, po |
November 21, 2006 |
| The present invention is related to novel processes for preparing anhydrous and hydrated forms of piperidine derivatives, polymorphs and pseudomorphs thereof of the formulas ##STR00001## which are useful as antihistamines, antiallergic agents and bronchodilators. |
| 6777555 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
August 17, 2004 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6566526 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
May 20, 2003 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6559312 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
May 6, 2003 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6555689 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
April 29, 2003 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6552200 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
April 22, 2003 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6548675 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
April 15, 2003 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6479663 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
November 12, 2002 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6441179 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
August 27, 2002 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##wherein W represents --C(.dbd.O)-- or --CH(OH)--; R.sub.1 represents hydrogen or hydroxy; R.sub.2 r |
| 6348597 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
February 19, 2002 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##whereinW represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hy |
| 6340761 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
January 22, 2002 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##whereinW represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hy |
| 6242606 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
June 5, 2001 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1##whereinW represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represents hy |
| 6147216 |
Intermediates useful for the preparation of antihistaminic piperidine derivatives |
November 14, 2000 |
| The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula ##STR1## wherein W represents --C(.dbd.O)-- or --CH(OH)--;R.sub.1 represents hydrogen or hydroxy;R.sub.2 represe |
| 6063793 |
Esters of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidi nemethano |
May 16, 2000 |
| The present invention is directed to esters of (+)-.alpha.-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A r |
| 6028083 |
Esters of (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
February 22, 2000 |
| The present invention is directed to esters of (+)-.alpha.-(2,3 Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, pharmaceutical formulations, methods of making and methods of using these esters. These compounds antagonize the effects of serotonin at the 5HT.sub.2A r |
| 6004980 |
(+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2- (4-fluorophenyl)ethyl]-4-piperidinemethanol |
December 21, 1999 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5962469 |
Cyclic nitrones |
October 5, 1999 |
| The present invention is directed to novel cyclic nitrones and their use in the prevention of oxidation tissue damage by free radicals, their use in the treatment of a number of disease states in which radicals either damage or destroy tissues via oxidation, and pharmaceutical compositio |
| 5874445 |
(+) -.alpha.- (2,3-dimethoxyphenyl)-1-(2-(4-fluorephenyl) ethyl)-4-piepridinemethanol |
February 23, 1999 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5739150 |
Piperidinyl thiacyclic derivatives |
April 14, 1998 |
| Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds. |
| 5721249 |
(+)-.alpha.-(2,3-di methoxyphenyl)-1-[2-(4-flurophenyl)etyl]-4-piperidinemethanol |
February 24, 1998 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5700813 |
(+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluor ophenyl)ethyl]-4-piperidinemethanol |
December 23, 1997 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5700812 |
(+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pip eridinemethanol |
December 23, 1997 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5677315 |
Cyclic nitrones |
October 14, 1997 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5650416 |
Piperidinyl thiacyclic derivatives |
July 22, 1997 |
| Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositi |
| 5631268 |
Piperidinyl thiacyclic derivatives |
May 20, 1997 |
| Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositi |
| 5602147 |
Piperidinyl thiacyclic derivatives |
February 11, 1997 |
| Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds. |
| 5596003 |
Piperidinyl thiacyclic derivatives |
January 21, 1997 |
| Piperidinyl thiacyclic derivatives useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods of treatment using these compounds. |
| 5561144 |
(+)-.alpha.-(2,3-dime thoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
October 1, 1996 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5541201 |
Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives |
July 30, 1996 |
| The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.s |
| 5541200 |
Piperidinyl thiacyclic derivatives |
July 30, 1996 |
| Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods |
| 5532252 |
Cyclic nitrones |
July 2, 1996 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5527812 |
Cyclic nitrones |
June 18, 1996 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5525615 |
Cyclic nitrones |
June 11, 1996 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5500433 |
Method of treating drug abuse |
March 19, 1996 |
| The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse. |
| 5498778 |
Cyclic nitrone compounds useful in treating stroke |
March 12, 1996 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5478846 |
1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia |
December 26, 1995 |
| The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents. |
| 5476861 |
Piperidinyl thiacyclic derivatives |
December 19, 1995 |
| Piperidinyl thiacyclic derivatives of the formula ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the specification, are useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors. Pharmaceutical compositi |
| 5397789 |
Cyclic nitrones |
March 14, 1995 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5380731 |
Antiallergic compounds |
January 10, 1995 |
| The present invention is directed to a new class of piperidinyl benzimidazoles that are useful in the treatment of allergic disorders. |
| 5371093 |
Piperidinyl thiacyclic derivatives |
December 6, 1994 |
| Piperidinyl thiacyclic derivatives ##STR1## wherein X, Y, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification. useful in the treatment of allergic diseases and diseases responding to antagonism of 5HT.sub.2 receptors, pharmaceutical compositions and a methods |
| 5292752 |
Antithrombotic compounds |
March 8, 1994 |
| The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists. |
| 5292746 |
Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock |
March 8, 1994 |
| The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents. |
| 5286866 |
Piperidinyl compounds |
February 15, 1994 |
| The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists. |
| 5169096 |
N-aralkyl-piperidine-methanol derivatives |
December 8, 1992 |
| This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5HT.sub.2 |
| 5166211 |
Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons |
November 24, 1992 |
| The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists. |
| 5162342 |
Use of 1,4-disubstituted-piperidinyl compounds for analgesia and muscle relaxation |
November 10, 1992 |
| The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants. |
| 5134149 |
(+)-.alpha.-(2,3-dimethoxyphenyl)-1-[ 2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
July 28, 1992 |
| The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidine methanol, and its use in the treatment of a number of disease states. |
| 5106845 |
Calcium antagonists |
April 21, 1992 |
| The present invention is directed to a new class of cyclic guanidines of the formula: ##STR1## in which Q is represented by a substituent selected from the group consisting of (CH.sub.2).sub.n in which n is an integer from 2-10, ##STR2## A is a substituent selected from the g |
| 5093341 |
N-aralkyl piperidine derivatives useful as antithrombolytic agents |
March 3, 1992 |
| The present invention is directed to a new class of compounds useful as antiarrhythmics, analgesics and serotonin 5HT.sub.2 antagonists, which compounds have the following formula: ##STR1## wherein; Y is represented by H, CO(CH.sub.2).sub.n CH.sub.3 in which n is an integer from |
| 5064838 |
1,4-disubstituted-piperidinyl compounds as pain relievers |
November 12, 1991 |
| The present invention relates to 1,4-disubstituted-piperidinyl compounds that have utility as analgesics and as muscle relaxants. |
