| Patent Number |
Title Of Patent |
Date Issued |
| 7456250 |
Thrombin peptide derivative dimers |
November 25, 2008 |
| Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or |
| 7378500 |
Use of thrombin-derived peptides for the therapy of chronic dermal ulcers |
May 27, 2008 |
| Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor. |
| 7304035 |
Stimulation of bone growth with thrombin peptide derivatives |
December 4, 2007 |
| Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. |
| 7291596 |
Pharmaceutical composition for thrombin peptide derivatives |
November 6, 2007 |
| Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activa |
| 7214661 |
Methods of therapy with thrombin derived peptides |
May 8, 2007 |
| The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention a |
| 7049294 |
Use of thrombin-derived peptides for the therapy of chronic dermal ulcers |
May 23, 2006 |
| Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor. |
| 7034001 |
Methods of therapy with thrombin derived peptides |
April 25, 2006 |
| The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention a |
| 6914050 |
Stimulation of bone growth with thrombin peptide derivatives |
July 5, 2005 |
| Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. |
| 6894027 |
Stimulation of bone growth with thrombin peptide derivatives |
May 17, 2005 |
| Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. |
| 6867190 |
Methods of therapy with thrombin derived peptides |
March 15, 2005 |
| The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention a |
| 6861407 |
Methods of therapy with thrombin derived peptides |
March 1, 2005 |
| The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention a |
| 6855687 |
Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin rece |
February 15, 2005 |
| Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated th |
| 6815416 |
Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin rece |
November 9, 2004 |
| Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated th |
| 6630572 |
Thrombin derived polypeptides: compositions and methods for use |
October 7, 2003 |
| Thrombin is now known to mediate a number of potent biological effects on cells bearing high-affinity thrombin receptors. These effects depend, at least in part, upon receptor occupancy signals generated by thrombin's interaction with the high affinity thrombin receptor. The present |
| 6602978 |
Synthetic peptide neutrophil cell chemotactic agents |
August 5, 2003 |
| These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neu |
| 6184342 |
Synthetic peptide neutrophil cell chemotactic agents |
February 6, 2001 |
| These compositions are new synthetic peptides and antibodies which are potent chemotactic agents for human neutrophils, and methods for their use. The specificity of these peptides is amino acid sequence specific for binding to a heretofore unidentified receptor on the surface of neu |
| 5500412 |
Thrombin derived polypeptides; compositions and methods for use |
March 19, 1996 |
| Thrombin is now known to mediate a number of potent biological effects on cells bearing high-affinity thrombin receptors. These effects depend, at least in part, upon receptor occupancy signals generated by thrombin's interaction with the high affinity thrombin receptor. The present |
