| Patent Number |
Title Of Patent |
Date Issued |
| RE33125 |
3- and 5-[3-(1-arylureido)]-1,2,4-triazoles |
December 5, 1989 |
|
| 5002944 |
Compounds having cardiotonic activity |
March 26, 1991 |
| Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure: ##STR1## where A is ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.9, an |
| 4954494 |
Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of conges |
September 4, 1990 |
| This invention relates to pyridyl-pyrazolinone compounds of the formula ##STR1## uses of said compounds as cardiotonic agents including methods for increasing cardia contractility and the treatment of congestive heart failure, pharmaceutical compositions including the same and method |
| 4868300 |
Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including |
September 19, 1989 |
| Compounds of the formula ##STR1## wherein: z is O or I;X is ##STR2## a and b are 0, 1, or 2 and a+b=0, 1 or 2; R, R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently hydrogen, alkyl or aralkyl;R.sub.n is hydrogen, alkyl, aralkyl, acyl, carbalkoxy, carbamyl, |
| 4859672 |
Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone |
August 22, 1989 |
| Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure ##STR1## wherein: A is ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.su |
| 4847264 |
Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
July 11, 1989 |
| A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment o |
| 4829066 |
Pyridooxazinone-pyridazinone and pyrazolone compounds, cardiotonic compositions including the sa |
May 9, 1989 |
| This invention relates to substituted pyridooxazinone pyridazinone and pyrazolone compounds, which are useful as cardiotonic agents for the treatment of congestive heart failure. This invention also relates to methods for increasing cardiac contractility using said compounds, and pha |
| 4826835 |
Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of conges |
May 2, 1989 |
| This invention relates to compounds of the formula ##STR1## where Het is imidazol-1-y or 1,2,4-triozol-1-yl and py is 2-,3- or 4-pyridyl; and the uses of said compounds including methods for increasing cardio contractility and in the treatment of congestive heart failure, pharmac |
| 4822794 |
Pyridooxazinone-pyridone compounds, cardiotonic compositions including the same, and their uses |
April 18, 1989 |
| This invention relates to substituted pyridooxazinone pyridones which are useful as cardiotonic agents for the treatment of congestive heart failure, to methods for increasing cardiac contractility using said compounds, and pharmaceutical compositions including the same. |
| 4818755 |
Bicyclic heteroaryl thiazole compounds, cardiotonic compositions including the same, and their u |
April 4, 1989 |
| Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation. |
| 4816583 |
3- and 5-(bicyclic ether or bicyclic alkylene thioether) alkylene amino thiatriazines |
March 28, 1989 |
| A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcero |
| 4806535 |
Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds an |
February 21, 1989 |
| This invention relates to imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds of the formula ##STR1## wherein A is CH or N and not more than one of W, X, Y and Z is a N atom which possess valuable pharmaceutical preparations, e.g., increasing |
| 4788187 |
Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical composition and use |
November 29, 1988 |
| A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4785101 |
Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their |
November 15, 1988 |
| Benzodiazinone-pyridazinone and -hydroxypyrazolyl compounds possess cardiotonic activity and are included in therapeutic cardiotonic compositions useful in methods for increasing cardiac contractility and for the treatment of congestive heart failure. |
| 4785005 |
6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses |
November 15, 1988 |
| This invention relates to 6-pyridone-carbostyril compounds, uses of said compounds, including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof. |
| 4783463 |
Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of conges |
November 8, 1988 |
| Compounds of the formula ##STR1## wherein: Het is imidazol-1-yl or 1,2,4-triazol-1-yl;py is 2-, 3-, or 4-pyridyl;R and R.sub.2 are H or alkyl;R.sub.1 is H, alkyl or vicinal R.sub.1 groups from a C--C double bond; and x is 0 or 1;or a pharmaceutically acceptable salt thereof, and pharmace |
| 4777168 |
Bicyclic benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use |
October 11, 1988 |
| A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting parmacological activity, including anti-secretory and anti-ulcerogenic activity, pharaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity a |
| 4764512 |
Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses |
August 16, 1988 |
| This invention relates to substituted benzodiazinone-pyridone compounds and their use as cardiotonic agents including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof. |
| 4748164 |
Bicyclic benzonoid alkylene amino thieno [3,4-D] isothiazole ethers and thioethethers, pharmaceu |
May 31, 1988 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcero-genic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4745110 |
Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
May 17, 1988 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4743608 |
Pyridone-pyridyl-imidazolyl and triazolyl compounds and their use as cardiotonic agents |
May 10, 1988 |
| This invention relates to pyridone-pyridyl-imidazolyl and triazolyl compounds, including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof. |
| 4743600 |
Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
May 10, 1988 |
| A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4742055 |
3- and 5-amino thiatriazines, and their pharmaceutical uses |
May 3, 1988 |
| A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including anti-ulcerogenic and gastrointestinal cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcero |
| 4727169 |
3- and 5-(bicyclic ether or bicyclic alkylene thioether) alkylene amino thiatriazines, and their |
February 23, 1988 |
| A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcero |
| 4725686 |
Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including |
February 16, 1988 |
| A method for increasing cardiotonic contractility in humans or other animals using a class of benzodiazinonepryidazinone and hydroxy-pyrazolyl compounds and pharmaceutical compositions including the same. |
| 4722925 |
Bicyclic benzo-oxy heterocyclic ethers and thioethers pharmaceutical compositions and use |
February 2, 1988 |
| A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastro-intestinal hyperacidity |
| 4721721 |
6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses |
January 26, 1988 |
| Cardiotonic fused aromatic bicyclic ring substituted thiazole compounds and their salts, methods for increasing cardiac contractility in humans and other mammals by the use of said compounds, pharmaceutical compositions including said compounds and methods for compound preparation. |
| 4714707 |
Aryl substituted heterocycles for treating gastrointestinal motility dysfunction |
December 22, 1987 |
| Aryl substituted diazaheterocyclic amines and their use in the treatment of gastrointestinal motility dysfunctions. |
| 4704388 |
3- And 5-(bicyclic ether or bicyclic alkylene thioether)alkylene amino thiatriazines, and their |
November 3, 1987 |
| A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcero |
| 4699906 |
Bicyclic benzenoid alkylene amino thieno[3,4-d]isothiazole ethers and thioethers, pharmaceutical |
October 13, 1987 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4692445 |
Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
September 8, 1987 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4689335 |
Heterocyclic guanidines for treating gastrointestinal motility dysfunction |
August 25, 1987 |
| A method for treating gastrointestinal motility dysfunctions using phenylheterocyclic guanidines and novel heterocyclic guanidine compounds. |
| 4668673 |
Bicycle benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use |
May 26, 1987 |
| A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4666913 |
Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same |
May 19, 1987 |
| A method for increasing cardiotonic contractility in humans or other animals using a class of hydroxy and aminothiazolyl-benzodiazinone compounds and pharmaceutical compositions including the same. |
| 4647559 |
Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
March 3, 1987 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4639442 |
Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
January 27, 1987 |
| A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4638001 |
Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
January 20, 1987 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4632927 |
Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
December 30, 1986 |
| A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including cytoprotective, H.sub.2 -antagonist, anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment o |
| 4612309 |
Antisecretory bicyclic benzo-oxy heterocyclic ethers and thioethers |
September 16, 1986 |
| A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastro-intestinal hyperacidity |
| 4595683 |
3- and 5-[bicyclic ether or bicyclic alkylene thioether]alkylene amino thiatriazines, and their |
June 17, 1986 |
| A class of 3- and 5-amino thiatriazine compounds exhibiting pharmacological activity, including gastrointestinal anti-ulcerogenic and cytoprotective activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcero |
| 4593028 |
5-hetero aryl-substituted-2-pyridones useful as cardiotonic agents for treatment of congestive h |
June 3, 1986 |
| Cardiotonic 5-heteroaryl-substituted-2-pyridone compounds, pharamaceutical compositions, and a method for the treatment of congestive heart failure. |
| 4588719 |
Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
May 13, 1986 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4563475 |
Guanidine derivatives for treating gastrointestinal motility dysfunction |
January 7, 1986 |
| A method for the treatment of a gastrointestinal motility dysfunction using a nitrogen containing heterocyclyl substituted acetylguanidine. |
| 4563460 |
Quinoline and quinazoline derivatives for treating gastrointestinal motility dysfunctions |
January 7, 1986 |
| A method for treating gastrointestinal motility dysfunctions using 2-amino-quinoline and -quinazoline derivatives. |
| 4563456 |
1,2,4-Triazines for treating gastrointestinal motility dysfunction |
January 7, 1986 |
| Method for treating gastrointestinal motility dysfunctions using 1,2,4-triazines. |
| 4562188 |
Triazinones for treating irritable bowel syndrome |
December 31, 1985 |
| A method for the treatment of irritable bowel syndrome using a 1,3,5-triazin-2-one and a class of 6-amino and 6-mercaptyl-1,3,5-triazin-2-one compounds. |
| 4543352 |
Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses |
September 24, 1985 |
| A class of naphthalene aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ul |
| 4539321 |
5-Diaza-aryl-3-substituted pyridone compounds |
September 3, 1985 |
| 5-Diaza-aryl-3-substituted-2-pyridone compounds useful for increasing cardiac contractility, pharmaceutical compositions and a method for the treatment of congestive heart failure comprising the use of said compounds. |
| 4529723 |
Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
July 16, 1985 |
| A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity |
| 4520025 |
Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
May 28, 1985 |
| A class of bicyclic nitrogen heterocyclic ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity a |
