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Inventor:
Bristol; James A.
Address:
Ann Arbor, MI
No. of patents:
23
Patents:




Patent Number Title Of Patent Date Issued
4820697 4,5-dihydro-4,4-dialkyl-6-(substituted)phenyl-3(2H)-pyridazinones useful as cardiotonic agents April 11, 1989
Novel 4,5-dihydro-4,4-dialkyl-6-(substituted)phenyl-3(2H)-pyridazinones having unexpected activity for use as cardiotonic and antihypertensive agents.
4734415 Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3( March 29, 1988
Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.Said compounds cause a significant increase in myocardial
4717730 4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions January 5, 1988
A novel method of producing 4,5-dihydro-6-(substituted)phenyl-5-methyl-3(2H)-pyridazinone compounds and the corresponding pharmaceutically acceptable salt compounds is provided as well as pharmaceutical compositions containing one or more of the compounds as active components of the
4701453 Substituted indeno-pyridazinones October 20, 1987
Substituted 2,5-dihydro- and 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
4663313 N.sup.6 -tricyclic adenosines for treating hypertension May 5, 1987
N.sup.6 -Tricyclic adenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical composition and methods for using said compounds and compositions are describ
4657898 N.sup.6 -substituted adenosines and method of use April 14, 1987
N.sup.6 -Substituted diarylalkyladenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compos
4657897 N.sup.6 -substituted adenosines for treating pain April 14, 1987
N.sup.6 -Substituted diarylalkyladenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compos
4626526 (S)-N.sup.6 -2-hydroxypropyladenosines December 2, 1986
(S)-N.sup.6 -2-Hydroxypropyladenosines and pharmaceutically acceptable acid addition salts having highly desirable antihypertensive properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
4607037 Cardiotonic 2(1H)-pyridinones August 19, 1986
Certain 2(1H)-pyridinones are cardiotonic agents. Methods for their preparation and use are disclosed.
4602019 Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents July 22, 1986
Substituted 2,5-dihydro- and 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
4593019 N.sup.6 -tricyclic adenosines June 3, 1986
N.sup.6 -Tricyclic adenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system and cardiovascular properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are de
4521416 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)- June 4, 1985
4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones 6-[(substituted)-1H- imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents.The above compounds cause a signifi
4507294 Imidazo[1,2-a]pyrazines March 26, 1985
There are disclosed herein certain substituted imidazo[1,2-a]pyrazine compounds which are useful in the treatment of peptic ulcer diseases.
4503061 Substituted phenyl-pyridinones as cardiotonic agents March 5, 1985
Certain 2(1H)-pyridinones are cardiotonic agents. Methods for their preparation and use are disclosed.
4464372 Imidazo[1,2-b]pyridazines August 7, 1984
There are disclosed herein certain substituted imidazo[1,2-b]pyridazine compounds which are useful in the treatment of peptic ulcer diseases.
4452788 Substituted 8-phenylxanthines June 5, 1984
Substituted 8-phenylxanthines and their use as bronchodilators is described. Methods for their preparation and use as well as pharmaceutical compositions containing them are also described.
4450164 Imidazo[1,2-A]pyridines and use May 22, 1984
This invention relates to imidazo[1,2-a]pyridine derivatives which are useful in the treatment of peptic ulcer diseases.
4428962 Indoles in treatment of peptic ulcers January 31, 1984
There are disclosed herein certain indole derivatives which are useful in the treatment of peptic ulcer diseases.
4409226 Imidazo[1,5-a]pyridines October 11, 1983
The invention relates to imidazo[1,5-a]pyridine derivatives which are useful in the treatment of peptic ulcer diseases.
4361567 Treatment of peptic ulcer disease November 30, 1982
Disclosed herein are certain imidazo[1,5-a]pyridines, and pharmaceutical compositions containing them as the active ingredient for treatment and promotion of healing of peptic ulcer disease by virtue of their antisecretory and cytoprotective properties.
4358454 1,3,4-Triazolo[1,5-a]pyridines November 9, 1982
There are disclosed herein certain 1,3,4-triazolo[1,5-a]pyridine compounds which are useful in the treatment of peptic ulcer diseases.
4358453 1,2,4-Triazolo[4,3-a]pyridines November 9, 1982
There are disclosed herein certain 1,2,4-triazolo-[4,3-a]pyridine compounds which are useful in the treatment of peptic ulcer diseases.
4353905 Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imid October 12, 1982
Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)-phenyl]-3(2H)-pyridazinone compounds and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic agents.Said compounds cause a significant increase in myocardial co


 
 
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