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Inventor:
Brechbiel; Martin W.
Address:
Annandale, VA
No. of patents:
12
Patents:












Patent Number Title Of Patent Date Issued
8288530 Method of preparing macromolecular contrast agents and uses thereof October 16, 2012
Disclosed are methods of preparing a macromolecular conjugated ligand and a metal complex thereof. The metal complex is targeted for use as a contrast agent, for example, in MRI. The method of preparing a macromolecular conjugated ligand comprises: (a) providing a compound of formula
7371225 Method for convection enhanced delivery of therapeutic agents May 13, 2008
A method for monitoring and controlling convection enhanced delivery of a therapeutic agent to a target tissue is disclosed. A tracer that is detectable, for example, by magnetic resonance imaging (MRI) and/or by X-ray computed tomography (CT) is co-infused with the therapeutic agent
7163935 Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of January 16, 2007
Substituted 1,4,7-triazacyclononane-N,N',N''-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.
7081452 Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of July 25, 2006
Substituted 1,4,7-triazacyclononane-N,N',N''-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder.
6995247 Ac-HEHA and related compounds, methods of synthesis and methods of use February 7, 2006
The present invention provides an .alpha.-particle-emitting radioisotope chelation complex comprising .sup.225Actinium (.sup.225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N',N',N',N',N'-hexaacetic acid (HEHA) (.sup.225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunct
6852842 Methods for functional kidney imaging using small dendrimer contrast agents February 8, 2005
Small dendrimer-based MRI contrast agents are disclosed to accumulate in renal tubules. The accumulation enables visualization of renal structure and function, permitting assessment of structural and functional damage to the kidneys. In a disclosed embodiment, six, small dendrimer-based
6696551 225Ac-HEHA and related compounds, methods of synthesis and methods of use February 24, 2004
The present invention provides an .alpha.-particle-emitting radioisotope chelation complex comprising .sup.225 Actinium (.sup.225 Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N',N",N'",N"",N'""-hexaacetic acid (HEHA) (.sup.225 Ac-HEHA). Also provided is a bifunctional HEHA, and a
6589966 Cytotoxic metal chelators and methods for making and using same July 8, 2003
A family of hexadentate Fe(II) chelators having marked antiproliferative activity against tumor cells is disclosed. The cytotoxic metal chelators and complexes of the present invention are represented by the general formula below: ##STR1##wherein: X.sup.1, X.sup.3, and X.sup.5 are
5434287 Bifunctional DTPA-type ligand July 18, 1995
The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds.
5428154 Complexes of functionalized tetraazacyclododecane chelates with bismuth, lead, ytriium, actinium June 27, 1995
The invention is a chelate of formula I: ##STR1## wherein R.sub.1-4 is --CH.sub.2 COOH;n is 1 to 5;X is a member selected from the group consisting of--NO.sub.2,--NH.sub.2,--NCS,--NHCOCH.sub.2 --Z, with Z being a member selected from the group consisting of Br and I,--COOH; and--OCH.sub.
5286850 Antibody DTPA-type ligand conjugates February 15, 1994
The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds. Antibody DTPA-type ligand conjugates are also provided.
5124471 Bifunctional DTPA-type ligand June 23, 1992
The subject matter of the present invention relates to bifunctional cyclohexyl DPTA ligands and methods for utilizing these compounds.










 
 
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