| Patent Number |
Title Of Patent |
Date Issued |
| 7189553 |
Modified subtilisins and detergent, compositions containing same |
March 13, 2007 |
| The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes ar |
| 6951878 |
Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases |
October 4, 2005 |
| The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP.alpha., LAR and HePT |
| 6908991 |
Useful mutations of bacterial alkaline protease |
June 21, 2005 |
| The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of |
| 6835821 |
Useful mutations of bacterial alkaline protease |
December 28, 2004 |
| The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of |
| 6808913 |
Useful mutations of bacterial alkaline protease |
October 26, 2004 |
| The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of |
| 6506589 |
Useful mutations of bacterial alkaline protease |
January 14, 2003 |
| The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess |
| 6410586 |
Modulators of protein tyrosine phosphatases (PTPases) |
June 25, 2002 |
| The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B. CD45, SHP-1, SHP-2, PTP.alpha., LAR and HePT |
| 6262044 |
Modulators of protein tyrosine phosphatases (PTPASES) |
July 17, 2001 |
| The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP.alpha., LAR and HePT |
| 6225329 |
Modulators of protein tyrosine phosphatases (PTPases) |
May 1, 2001 |
| The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP- |
| 6197567 |
Modified subtilisins and detergent compositions containing same |
March 6, 2001 |
| Enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented.The enzyme exhibit improved wash performance in comparison to their wild type parent enzymes.The enzymes are well-suited for use in detergent compositi |
| 6169087 |
Modulators of protein tyrosine phosphatases (PTPases) |
January 2, 2001 |
| The present invention provides novel compounds of Formula 1 or Formula 2 and compositions thereof, methods of their use, and methods of their manufacture, ##STR1##wherein X, Y, Z, W, R.sub.1, R.sub.2 and R.sub.3 are defined more fully in the description. These compounds are useful in |
| 5858757 |
Stabilized enzymes and detergent compositions |
January 12, 1999 |
| The invention relates to stabilized subtilisin proteases wherein one or more prolines is substituted for a native amino acid at stabilizing positions defined both by the range of the dihedral angles in the primary structure present at the substitution site and by selected characteristics |
| 5843753 |
Metalloprotease having increased activity |
December 1, 1998 |
| The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells com |
| 5807729 |
Metalloprotease having increased activity |
September 15, 1998 |
| The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells com |
| 5741694 |
Useful mutations of bacterial alkaline protease |
April 21, 1998 |
| The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess |
| 5702934 |
Processes for producing an enzyme |
December 30, 1997 |
| The present invention is related to a process for producing an active enzyme comprising fermenting the proform of the active enzyme in the present of a proteolytic enzyme different from the active enzyme and capable of converting the proenzyme into an active enzyme as well as to host |
| 5693520 |
Recombinant trypsin-like protease |
December 2, 1997 |
| An active recombinant trypsin-like protease enzyme comprising the amino acid residues 25-224 of the amino acid sequence of SEQ ID NO:2, as well as a DNA construct encoding the enzyme and comprising the sequence of SEQ ID NO:1. The enzyme may be used as a detergent enzyme. |
| 5691162 |
Metalloprotease having increased activity |
November 25, 1997 |
| The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells com |
| 5665587 |
Modified subtilisins and detergent compositions containing same |
September 9, 1997 |
| The present invention relates to modified subtilisins comprising a mutation in an amino acid sequence of a subtilisin at a position selected from the group consisting of 1, 2, 3, 4, 6, 9, 10, 12, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 27, 36, 37, 38, 40, 41, 43, 44, 45, 46, 49, 50, 51, |
| 5631217 |
Detergent compositions comprising a modified subtilisin |
May 20, 1997 |
| This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions cont |
| 5482849 |
Subtilisin mutants |
January 9, 1996 |
| This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions cont |
| 5208158 |
Oxidation stable detergent enzymes |
May 4, 1993 |
| Novel chemically modified detergent enzymes are provided, wherein one or more methionines have been mutated into cysteines, said cysteines subsequently being chemically modified in order to confer the enzyme improved stability towards oxidative agents. A novel process for stabilizing |
