| Patent Number |
Title Of Patent |
Date Issued |
| 7449489 |
Indolylalkylamino-methylidenecarbamate derivatives useful as GnRH antagonists |
November 11, 2008 |
| The invention relates to a group of novel indole compounds of Formula (I): wherein: R.sup.1, R.sup.2, R.sup.4, R.sup.6, R.sup.6a, R.sup.7, R.sup.8, R.sup.9, R.sup.10, and A are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention |
| 7030123 |
Indole derivatives with vascular damaging activity |
April 18, 2006 |
| The invention provides a compound of Formula (I). ##STR00001## Wherein R1, R2, R3, R10 and R11 have the meanings given in the description. Such compounds are predicted to cause the selective destruction of tumour vasculature. They may therefore be used to inhibit and/or reverse, and/or |
| 6946468 |
3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
September 20, 2005 |
| The present invention relates to inhibitors of ras farnesylation of the Formula I ##STR1##wherein: R.sup.1 is for example H and further values as defined in the specification; R.sup.2 is for example H and further values as defined in the specification; R.sup.3 is for example H or |
| 6541491 |
4-mercaptopyrrolidine derivatives as farnesyl transferase inhibitors |
April 1, 2003 |
| Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R.sup.1 is for example H and further values as defined in the specification; R.sup.2 is for example H and further values as defined in the specification; R.sup.3 is for example H or a substit |
| 6414145 |
Imidazolyl compounds as inhibitors of farnesyl-protein tranferase |
July 2, 2002 |
| ##STR1##The present invention relates to inhibitors of ras farnesylation of Formula (I), wherein T is of Formula (1) or (2) or (3); A is aryl or heteroaryl; B is aryl or heteroaryl; X and Y represent hydrogen, or both X and Y can represent a single bond (so as to form a double bond); R.s |
| 6232338 |
4-Mercaptopyrrolidine derivatives as farnesyl transferase inhibitors |
May 15, 2001 |
| Pharmaceutical compositions comprising an inhibitor of ras farnesylation of formula (I) wherein, R.sup.1 is for example H and further values as defined in the specification; R.sup.2 is for example H and further values as defined in the specification; R.sup.3 is for example H or a substit |
| 5985281 |
Chemical compounds |
November 16, 1999 |
| A two component system for therapeutic treatment of a host, having a first component comprising a targeting moiety capable of binding with a tumour associated antigen, linked to a mutated enzyme capable of converting a prodrug into an antineoplastic drug, and a second component comprisin |
