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Inventor: Boshagen; Horst
Address: Haan, DE
No. of patents: 40
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 5432282 |
Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine derivatives |
July 11, 1995 |
| The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5420142 |
Certain 3-formyl-1, 4-dihydropyridines and their pharmaceutical composition and use |
May 30, 1995 |
| The present invention relates to the use of 3-formyl-1,4-dihydropyridine derivatives as medicaments for the control of cardiovascular diseases, in particular of pathologically changed blood pressure and of cardiac insufficiency, new compounds and a process for their preparation. |
| 5412099 |
Intermediate benzothiazolyl- and benzoxazolyl-aldehyde compounds |
May 2, 1995 |
| Intermediate compounds of formula IIwherein R.sup.3 is ##STR1## and R.sup.6 and R.sup.7 are as defined in the specification, are useful to make compounds having cardiovascular activity. |
| 5380851 |
2-amino-5-cyano-1,4-dihydropyridines, processes for their preparation |
January 10, 1995 |
| The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5254692 |
2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
October 19, 1993 |
| 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl hav |
| 5225558 |
2-amino-5-cyano-1,4-dihydropyridines, and their use in medicaments |
July 6, 1993 |
| The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5204472 |
Quinoline and isoquinoline intermediates |
April 20, 1993 |
| Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a la |
| 5200420 |
2,6-dialkyl-4-(benzothiazol- or benzoxazol-4-yl-1,4-dihydropyridines |
April 6, 1993 |
| 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl hav |
| 5100900 |
Positive inotropically active 4-quinolyl-dihydropyridines and use thereas |
March 31, 1992 |
| Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a la |
| 5096897 |
Antithrombotic substituted cycloalkano(b)dihydroindole- and -indole-sulphonamides |
March 17, 1992 |
| Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X |
| 5079258 |
Tetrahydro-1-benz-(C,D)-indolepropionic acid sulphonamides as thrombocyte aggregation inhibitors |
January 7, 1992 |
| Tetrahydro-1-benz-[c,d],indolepropionic acid sulphonamides of the formula ##STR1## can be prepared by reaction of tetrahydro-1-benz-[c,d]-indolesulphonamides with acrylonitrile and subsequent hydrolysis. The new compounds can be employed inhibiting thrombocyte aggregation. |
| 5051407 |
Methods for treating viruses in patients by administering 2-hydroxymethylene-3,4,5-trihydroxypip |
September 24, 1991 |
| A method for treating a viral infection in a human or animal patient comprising administering to such patient an antivirally effective amount of a substituted hydroxypiperidine, namely a 2-hydroxymethylene-3,4,5-trihydroxypiperidine. |
| 5039670 |
Antithrombotic substituted cycloalkano(B)dihydroindole- and -indole-sulphonamides and use |
August 13, 1991 |
| Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X i |
| 5015657 |
2-halogen-substituted N-indolylethyl-sulphonamides and inhibiting platelet aggregation and antag |
May 14, 1991 |
| Inhibiting platelet aggregation and antagonizing thromboxane A.sub.2 with new 2-halogen-substituted N-indolyethyl-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl having up to 8 carbon atoms, orrepresents |
| 4988820 |
Cycloalkano(1,2-B) indole-sulponamides |
January 29, 1991 |
| Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula --S(O).sub.m R.sup.3, in which R.sup.3 denotes alkyl or aryl, and m denotes one of the numbers |
| 4965258 |
Cycloalkano(1,2-B)indole-sulphonamides, pharmaceutical compositions and use |
October 23, 1990 |
| Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A.sub.2. |
| 4940705 |
N-substituted derivatives of 1-desoxynojirimycin and 1-desoxymannonojirimycin and pharmaceutical |
July 10, 1990 |
| N-substituted derivatives of 1-desoxynojirimycin and 1-desoxymannojirimycin of the formula ##STR1## in which one of R and R' are hydroxyl and the other is hydrogenn is a number from 1 to 6R.sup.1 is hydrogen, alkyl or benzyl andR.sup.2 is alkyl which is optionally substituted by an optio |
| 4904797 |
Process of preparing cycloalkano(1,2-B)indole-sulphonamides |
February 27, 1990 |
| Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2. |
| 4895855 |
Mixture of different dihydropyridines |
January 23, 1990 |
| A composition effective for treating circulation disorders comprises a mixture of ##STR1## wherein the variables can have varied meetings. I are inotropic and II are vasodilating but, whereas the ingredients in the combination would be expected to be antagonistic, they are reinfo |
| 4882353 |
Chroman derivatives for combating thrombosis and asthma |
November 21, 1989 |
| For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano,R.sup.2 and R.sup.3 are identical or different and stand for h |
| 4853406 |
Polyhydrobenzi[c,d]indolesulphonamides |
August 1, 1989 |
| Thrombocyte aggregation-inhibiting polyhydrobenz[c,d]indolesulphonamide of the formula ##STR1## in which R.sup.1 is hydrogen, aryl or alkyl,R.sup.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, hydroxyl, aralkoxy ora group of the formula ##STR2## R.s |
| 4843091 |
Indolylpropionic acids, compositions of, and use thereof to inhibit thrombocyte aggregation |
June 27, 1989 |
| An N-sulphonamidoethyl-indole of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, aryl, arylthio, aralkyl, aralkoxy, aralkylthio, acyl or a group of the formula |
| 4827032 |
Cycloalkyl-one-containing benzenesulphonamides |
May 2, 1989 |
| Cycloalkanol[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2. |
| 4822798 |
Circulation-active 4-phenyl-6-substituted dihydropyrimidines |
April 18, 1989 |
| Circulatory system-active novel dihydropyrimidines of the formula ##STR1## in which R.sup.1 and R.sup.6 are diverse organic radicals, and pharmacologically acceptable addition salts thereof. |
| 4806667 |
Promoting production of useful livestock with silylated aminophenylethylamine derivatives |
February 21, 1989 |
| A method for promoting production of useful livestock comprising administering to such livestock an amount effective therefor of a monosilylated aminopheylethylamine derivative of the formula ##STR1## in which X and Y are identical or different and represent hydrogen or CN,R.sup.2 re |
| 4806551 |
N-dihydroindolylethyl-sulphonamides |
February 21, 1989 |
| New N-dihydroindolylethyl-sulphonamides are prepared from the corresponding N-indolylethyl-sulphonamides by oxidation or hydrogenation and are useful as active compounds in medicaments. These compounds exhibit a platelet aggregation-inhibiting and thromboxan A.sub.2 -antagonistic action. |
| 4774240 |
N-indolylethyl-sulphonic acid amides and their use |
September 27, 1988 |
| The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are defined in the specification and X is carboxyl, alkoxycarbonyl, cyano or carboxamido. These active compounds are useful in medicaments |
| 4670423 |
Monosilylated aminophenylethylamine derivatives, a process for their preparation, and their use |
June 2, 1987 |
| Monosilylated aminophenylethylamine derivative of the formula ##STR1## in which X and Y each independently is hydrogen or halogen,R.sub.1 is the radical ##STR2## R.sub.2 is hydrogen or an aliphatic hydrocarbon radical having up to 10 C atoms,R.sub.3 is hydrogen, an aliphatic hydr |
| 4659844 |
Cyclic ethers which are substituted in a .alpha.-position by an isocyanide-dichloride group, and |
April 21, 1987 |
| The invention relates to new cyclic ethers which are substituted in the .alpha.-position by an isocyanide-dichloride group, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n have the meaning indicated in the description, and to a process for their |
| 4590291 |
Thrombin inhibitory new dihydroxybenzene ether derivatives |
May 20, 1986 |
| An ether derivative of a dihydroxybenzene of the formula ##STR1## in which R.sup.1 is 1 to 3 identical or different substituents selected from hydrogen, halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto and carbalkoxy, with in each case 1 to 4 carbon atoms in the a |
| 4565888 |
Substituted salicylic acid amide anthelmintics |
January 21, 1986 |
| Anthelmintically active novel substituted salicylic acid amides of the formula ##STR1## in which X and Y each independently is halogen, and,R.sup.1 is hydrogen or acetyl. |
| 4540684 |
3-Nitro-5-amide-1,4-dihydropyridines with positive inotropic activity |
September 10, 1985 |
| A 1,4-dihydropyridine derivative of the formula ##STR1## in which R and R.sub.1 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 to C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, trifluoromethyl, ##STR2## X is oxygen or sulphur, R.sub.4 an |
| 4532248 |
Method of combatting coronary and vascular diseases |
July 30, 1985 |
| 1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, andR.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary |
| 4492703 |
4-(2-Substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters active on blood circul |
January 8, 1985 |
| 1,4-Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.4, R.sup.5, R.sup.6 and Y are hydrogen or various organic radicals,R.sup.2 and R.sup.3 are various organic radicals, ##STR2## is phenyl, naphthyl or various heterocyclic radicals, X is a direct bond, O, S o |
| 4465684 |
3,4,5-Trihydroxypiperidine compounds and their use as medicaments and in animal nutrition |
August 14, 1984 |
| The invention relates, inter alia, to 3,4,5-trihydroxypiperidine compounds of Formula (I), infra, to methods for the manufacture of said compounds, to pharmaceutical compositions containing said compounds and to methods for the use of said compounds and compositions. Also included in the |
| 4349560 |
Antimycotic imidazolyl-indeno-thiophene compounds, composition and method of use |
September 14, 1982 |
| The invention relates to imidazolyl-indenothiophene compounds of Formula (I) and a process for their production. Also included in the invention are antimycotic compositions containing said imidazolyl-indenothiophene compounds and methods for the use of said compounds and compositions. |
| 4328233 |
.alpha.-Glucosidase inhibiting 2-hydroxymethyl-3,4,5-trihydroxy-piperidines |
May 4, 1982 |
| The invention relates to 2-hydroxymethyl-3,4,5-trihydroxy-6-substituted-piperidines and methods for their preparation. The invention also includes compositions containing said 2-hydroxymethyl-3,4,5-trihydroxy-6-substituted-piperidines and the use of said compounds and compositions fo |
| 4190663 |
Anti-thrombotic 1,2-benzisothiazolin-3-ones |
February 26, 1980 |
| 6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazolin-3-one is a representative |
| 4156729 |
1,2-Benzisothiazolin-3-ones |
May 29, 1979 |
| 6-Substituted-1,2-benzisothiazolin-3-ones carrying an aminoalkyl group in the 2-position and being optionally substituted in the 4- and/or 5-position are antithrombotic agents. The compounds, of which 2-(2-diethylaminoethyl)-4,5-dimethyl-1,2-benzisothiazolin-3-one is a representative |
| 4153702 |
Basically alkylated dithiosalicyclic acid amides and their use as medicaments |
May 8, 1979 |
| The invention provides novel antithrombotics diphenyl-disulphide-2,2'-bis-carboxylic acid amides of the general formula ##STR1## in which R.sup.1 represents a hydrogen or halogen atom or an optionally substituted alkyl, alkoxy or aralkoxy group,R.sup.2 represents a hydrogen or haloge |
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