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Inventor:
Borders; Donald B.
Address:
Suffern, NY
No. of patents:
29
Patents:












Patent Number Title Of Patent Date Issued
RE29903 Antibacterial antibiotics AM31.alpha., AM31.beta. and AM31.gamma. February 6, 1979
This disclosure describes a novel class of antibiotics, three of which have been designed AM31.alpha., AM31.beta., and AM31.gamma. and are produced in a microbiological fermentation under controlled conditions using a new strain of Streptoverticillium netropsis.
7868135 Compositions of lipopeptide antibiotic derivatives and methods of use thereof January 11, 2011
The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in
7138487 Extractive purification of lipopeptide antibiotics November 21, 2006
The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of a
6767718 Lipodepsipeptide antibiotics and methods of preparation July 27, 2004
Novel cyclodepsipeptide intermediates have been prepared from the A21978 complex and used to synthesize new lipodepsipeptide antibiotics. The three intermediates can be readily derivatized to give new families of antibiotics that have potent antibacterial activity against gram positive
6750199 Antimicrobial sulfonamide derivatives of lipopeptide antibiotics June 15, 2004
The present invention provides antimicrobial sulfonamide derivatives of lipopeptide antibiotics, pharmaceutical compositions of antimicrobial sulfonamide derivatives, methods for making antimicrobial sulfonamide derivatives, methods for inhibiting microbial growth with antimicrobial
6737403 Derivatives of laspartomycin and preparation and use thereof May 18, 2004
The present invention provides laspartomycin core peptides, laspartomycin core peptide derivatives, antimicrobial laspartomycin derivatives, methods for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial laspart
6716962 Extractive purification of lipopeptide antibiotics April 6, 2004
The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of a
6613889 Method for preparing salts of polyene macrolide esters September 2, 2003
This method is for preparing salts of amphotericin B methyl ester and other polyene macrolide esters. The steps of the process involve methylation by use of cesium carbonate for converting to methyl ester and significantly reducing side products, which are over methylation products. The
6511962 Derivatives of laspartomycin and preparation and use thereof January 28, 2003
The present invention provides a laspartomycin core peptide, a laspartomycin core peptide derivative, a antimicrobial laspartomycin derivative, a method for making laspartomycin core peptides, methods for making laspartomycin core peptide derivatives, methods for making antimicrobial
5077277 Chemical derivatives of antibiotics LL-E19020 alpha and beta December 31, 1991
Derivatives of antibiotics derived from the microorganism Streptomyces lydicus subspecies tanzanius, referred to as antibiotics LL-E19020 alpha and beta, are produced by chemical reaction. The derivatives are also active antibiotics useful in the treatment of bacterial infections.
4968493 Method for controlling chronic respiratory disease, fowl cholera and necrotic enteritis in avian November 6, 1990
This invention provides a method for treating chronic respiratory disease, fowl cholera and necrotic enteritis in infected birds, by orally administering thereto a pharmaceutically effective amount of antibiotic LL-E19020.alpha., antibiotic LL-E19020.beta. or a physiologically accept
4870019 Antibiotic LL-C19004 September 26, 1989
A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
4859598 Antibiotic LL-D42067.beta. August 22, 1989
Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
4774184 Culture and process for producing antibiotic LL-D42067alpha September 27, 1988
The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope t
4705688 Antibiotic LL-E19020 .alpha. and .beta. November 10, 1987
This invention relates to antibiotic LL-E19020.alpha. and LL-E19020.beta. derived from the microorganism Streptomyces lydicus subspecies tanzanius NRRL 18036, which are useful as an antibacterial agent.
4699790 Antibiotic LL-C19004 October 13, 1987
A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
4677071 Antibiotic agents from S. coeruleorubidus, rubidus June 30, 1987
This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus
4650765 Biologically pure culture of Streptoverticillium stramineum sp. nov. March 17, 1987
This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
4626503 Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194 December 2, 1986
Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
4608343 Biologically pure culture of Streptomyces majorciensis Labeda August 26, 1986
This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Strept
4578468 Antibiotic LL-D42067.beta. March 25, 1986
Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
4568646 Preparation of antibiotic LL-D05139.beta. from cultures of Glycomyces harbinensis, gen. nov., sp February 4, 1986
This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
4552867 Antibiotic LL-BO1208.alpha. and LL-BO1208.beta., process of preparation, pharmaceutical composit November 12, 1985
This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
4551533 Antibiotic LL-D42067.alpha. November 5, 1985
Antibiotic LL-D42067.alpha. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
4534970 Antibacterial antibiotics LL-CO8078.alpha..sub.1, .alpha..sub.2, .alpha..sub.3 and .beta. August 13, 1985
This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Strept
4503044 Antibiotic LL-D05139 .beta. March 5, 1985
This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
4499075 Antibiotic agents from S. coeruleorubidus, rubidus February 12, 1985
This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus
4384043 Process for producing the antibiotic nosiheptide May 17, 1983
This disclosure describes a novel process for the production of the known antibiotic nosiheptide using a new strain of Streptomyces glaucogriseus and mutants thereof.
4234717 Antibacterial antibiotic BM782 November 18, 1980
This disclosure describes three new antibiotics designated BM782.alpha.1, BM782.alpha.2, and BM782.alpha.1a which are produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of the genus Nocardia or mutants thereof. These new










 
 
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