| Patent Number |
Title Of Patent |
Date Issued |
| 7176256 |
Biocompatible crosslinked composition |
February 13, 2007 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 7151135 |
Crosslinked polymer compositions |
December 19, 2006 |
| Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a |
| 6969400 |
Synthetic implant with nonimmunogenicity coating |
November 29, 2005 |
| Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a |
| 6911496 |
Composition for administration of a biologically active compound |
June 28, 2005 |
| Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a |
| 6653450 |
Mutated recombinant collagens |
November 25, 2003 |
| The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent |
| 6534591 |
Cross-linked polymer compositions and methods for their use |
March 18, 2003 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 6472171 |
Expression of procollagen in yeast |
October 29, 2002 |
| The invention discloses methods for effecting the production of recombinant mammalian procollagen in yeast, as well as compositions comprising yeast cells cap producing mammalian procollagen. |
| 6323278 |
Method of making crosslinked polymer matrices in tissue treatment applications |
November 27, 2001 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 6166130 |
Method of using crosslinked polymer compositions in tissue treatment applications |
December 26, 2000 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 6165489 |
Crosslinked collagen compositions for in situ administration |
December 26, 2000 |
| The present invention discloses a novel, injectable crosslinked collagen composition which is able to continue crosslinking after injection to a soft or hard tissue site in order to anchor the collagen implant to the host tissue. The composition comprises particulate crosslinked collagen |
| 6051648 |
Crosslinked polymer compositions and methods for their use |
April 18, 2000 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 5962648 |
Production of human recombinant collagen in the milk of transgenic mammals |
October 5, 1999 |
| Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and re |
| 5895833 |
Production of human recombinant collagen in the milk of transgenic animals |
April 20, 1999 |
| Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and re |
| 5874500 |
Crosslinked polymer compositions and methods for their use |
February 23, 1999 |
| Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene gly |
| 5807581 |
Collagen-based injectable drug delivery system and its use |
September 15, 1998 |
| Drugs are delivered in a sustained manner from an in vivo depot which is formed from a collagen-based injectable composition. The injectable composition is fluid when injected but undergoes crosslinking in situ to form a crosslinked collagen matrix which encloses the drug to be released. |
| 5800541 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction |
September 1, 1998 |
| The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer |
| 5752974 |
Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
May 19, 1998 |
| Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, |
| 5643464 |
Process for preparing a sterile, dry crosslinking agent |
July 1, 1997 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5550187 |
Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
August 27, 1996 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5527856 |
Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
June 18, 1996 |
| The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, |
| 5510418 |
Glycosaminoglycan-synthetic polymer conjugates |
April 23, 1996 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5510121 |
Glycosaminoglycan-synthetic polymer conjugates |
April 23, 1996 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5476666 |
Glycosaminoglycan-synthetic polymer conjugates |
December 19, 1995 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
| 5475052 |
Collagen-synthetic polymer matrices prepared using a multiple step reaction |
December 12, 1995 |
| The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer |
| 5470911 |
Glycosaminoglycan-synthetic polymer conjugates |
November 28, 1995 |
| Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluroni |
