| Patent Number |
Title Of Patent |
Date Issued |
| 8236525 |
Reduced phosphotransferase system activity in bacteria |
August 7, 2012 |
| A method of producing biological products using bacteria with an inactivated ptsHI and wild type err and no added glucose transport activity and which consumes nearly all glucose in the media is described. The .DELTA.ptsHI bacteria produce large quantities of recombinant protein with |
| 8084243 |
Blocking sporulation by inhibiting SpoIIE |
December 27, 2011 |
| We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to |
| 7935511 |
Aerobic succinate production in bacteria |
May 3, 2011 |
| Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. |
| 7927859 |
High molar succinate yield bacteria by increasing the intracellular NADH availability |
April 19, 2011 |
| The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH. |
| 7790416 |
Mutant E. coli strain with increased succinic acid production |
September 7, 2010 |
| The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions. |
| 7709261 |
Recycling system for manipulation of intracellular NADH availability |
May 4, 2010 |
| The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NA |
| 7569380 |
Simultaneous anaerobic production of isoamyl acetate and succinic acid |
August 4, 2009 |
| In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance between NADH and NAD+. |
| 7432090 |
Blocking sporulation by inhibiting SpoIIE |
October 7, 2008 |
| We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to |
| 7326557 |
Increasing intracellular NADPH availability in E. coli |
February 5, 2008 |
| A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the overall production of the desired protein. |
| 7262046 |
Aerobic succinate production in bacteria |
August 28, 2007 |
| Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. |
| 7256016 |
Recycling system for manipulation of intracellular NADH availability |
August 14, 2007 |
| The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NA |
| 7244610 |
Aerobic succinate production in bacteria |
July 17, 2007 |
| Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid. |
| 7223567 |
Mutant E. coli strain with increased succinic acid production |
May 29, 2007 |
| The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions. |
