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Inventor:
Bennett; George N.
Address:
Houston, TX
No. of patents:
13
Patents:












Patent Number Title Of Patent Date Issued
8236525 Reduced phosphotransferase system activity in bacteria August 7, 2012
A method of producing biological products using bacteria with an inactivated ptsHI and wild type err and no added glucose transport activity and which consumes nearly all glucose in the media is described. The .DELTA.ptsHI bacteria produce large quantities of recombinant protein with
8084243 Blocking sporulation by inhibiting SpoIIE December 27, 2011
We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to
7935511 Aerobic succinate production in bacteria May 3, 2011
Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.
7927859 High molar succinate yield bacteria by increasing the intracellular NADH availability April 19, 2011
The invention relates to increasing the yield of succinate in bacteria by increasing the intracellular availability of cofactors such as NADH.
7790416 Mutant E. coli strain with increased succinic acid production September 7, 2010
The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.
7709261 Recycling system for manipulation of intracellular NADH availability May 4, 2010
The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NA
7569380 Simultaneous anaerobic production of isoamyl acetate and succinic acid August 4, 2009
In vivo method of producing esters from acetyle coA, such as isoamyl acetate and succinate, has been developed by producing null mutants in pathways that use acetyl coA and by overexpressing products that use NADH and in order to maintain the proper redox balance between NADH and NAD+.
7432090 Blocking sporulation by inhibiting SpoIIE October 7, 2008
We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to
7326557 Increasing intracellular NADPH availability in E. coli February 5, 2008
A method of increasing cellular NADPH levels by expressing one or more genes that encode a enzyme that causes the production of NADPH. The system can be combined with other enzymes that require NADPH, thus improving the overall production of the desired protein.
7262046 Aerobic succinate production in bacteria August 28, 2007
Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.
7256016 Recycling system for manipulation of intracellular NADH availability August 14, 2007
The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NA
7244610 Aerobic succinate production in bacteria July 17, 2007
Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.
7223567 Mutant E. coli strain with increased succinic acid production May 29, 2007
The invention relates to a mutant strain of bacteria, which either lacks or contains mutant genes for several key metabolic enzymes, and which produces high amounts of succinic acid under anaerobic conditions.










 
 
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