| Patent Number |
Title Of Patent |
Date Issued |
| 7553830 |
Compositions for the delivery of negatively charged molecules |
June 30, 2009 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex |
| 7176304 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothel |
February 13, 2007 |
| The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFR1, VEGFR2 and/or VEGFr3) gene expression in a variety of applications, includi |
| 7109165 |
Conjugates and compositions for cellular delivery |
September 19, 2006 |
| This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules. |
| 7071311 |
Antibodies having specificity for 2'-C-allyl nucleic acids |
July 4, 2006 |
| The present invention relates to antibodies, antibody conjugates, and compositions thereof, methods of antibody synthesis, and applications of antibodies useful for detecting the presence of nucleic acid molecules in vivo, such as in a clinical setting. The antibodies of the invention ar |
| 7041817 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
May 9, 2006 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 6972330 |
Chemical synthesis of methoxy nucleosides |
December 6, 2005 |
| Process for chemical synthesis of methoxy nucleosides. |
| 6849726 |
Non-nucleotide containing RNA |
February 1, 2005 |
| The present invention relates to RNA molecules containing one or more non-nucleotide mimetics. |
| 6831171 |
Nucleic acid catalysts with endonuclease activity |
December 14, 2004 |
| The present invention relates to novel Nucleic acid catalysts, methods of synthesis, and uses thereof. |
| 6818759 |
2'-O-alkylthioalkyl and 2'-C-alkylthioalkyl-containing nucleic acids |
November 16, 2004 |
| A compound having the formula: ##STR1##wherein, R1 represents 2'-O-alkylthioalkyl or 2'-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group. |
| 6797815 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
September 28, 2004 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6686463 |
Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives |
February 3, 2004 |
| The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2'-amino, 2'-N-phthaloyl, 2'-O-methyl, 2'-O-silyl, 2'-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside deri |
| 6673611 |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
January 6, 2004 |
| This invention relates to novel chemically-modified nucleic acid molecules having specific formulae that exhibit increased resistance to nucleases and increased binding affinity to target nucleic acid molecules. The invention further relates to methods of modulating gene expression using |
| 6656731 |
Nucleic acid catalysts with endonuclease activity |
December 2, 2003 |
| The present invention relates to nucleic acid molecules with new motifs having catalytic activity, methods of syntheses and uses thereof. |
| 6649751 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
November 18, 2003 |
| Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification. |
| 6602858 |
Nucleic acid catalysts comprising L-nucleotide analogs |
August 5, 2003 |
| A nucleic acid catalyst comprising at least one L-nucleotide substitution. |
| 6586238 |
Enzymatic nucleic acids containing 5'-and or 3'-cap structures |
July 1, 2003 |
| An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide. |
| 6555668 |
Non-nucleotide containing enzymatic nucleic acid |
April 29, 2003 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 6548657 |
Method for screening nucleic acid catalysts |
April 15, 2003 |
| Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described. |
| 6528639 |
Base-modified enzymatic nucleic acid |
March 4, 2003 |
| Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core. |
| 6509460 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
January 21, 2003 |
| Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed. |
| 6506888 |
2'-O-amino-containing nucleoside analogs and polynucleotides |
January 14, 2003 |
| Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides. |
| 6489465 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
December 3, 2002 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6482932 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
November 19, 2002 |
| Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. |
| 6469158 |
Synthesis, deprotection, analysis and purification of RNA and ribozymes |
October 22, 2002 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 6451540 |
2'-O-alkylthioalkyl and 2'-C-alkythioalkyl containing nucleic acids |
September 17, 2002 |
| A compound having the formula: ##STR1##wherein, R1 represents 2'-O-alkylthioalkyl or 2'-C-alkylthioalkyl; X represents a base or H; Y represents a phosphorus-containing group; and R2 represents H, DMT or a phosphorus-containing group. |
| 6437117 |
Synthesis, deprotection, analysis and purification for RNA and ribozymes |
August 20, 2002 |
| Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form. |
| 6395713 |
Compositions for the delivery of negatively charged molecules |
May 28, 2002 |
| This invention features permeability enhancer molecules, and methods, to increase membrane permeability of negatively charged polymers thereby facilitating cellular uptake of such polymers. |
| 6379954 |
Amido and peptido modified catalytic oligonucleotides |
April 30, 2002 |
| Oligonucleotide comprising a nucleotide base having the formula: ##STR1##wherein B is a nucleotide base or hydrogen; R.sub.1, R.sub.2 and R.sub.3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an amine, |
| 6365374 |
2'-deoxy-2'-alkylnucleotide containing nucleic acid |
April 2, 2002 |
| 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules. |
| 6362323 |
Non-nucleotide containing nucleic acid |
March 26, 2002 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 6316612 |
Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides |
November 13, 2001 |
| Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides. |
| 6280936 |
Method for screening nucleic acid catalysts |
August 28, 2001 |
| Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described. |
| 6251666 |
Nucleic acid catalysts comprising L-nucleotide analogs |
June 26, 2001 |
| A nucleic acid catalyst comprising at least one L-nucleotide substitution. |
| 6248878 |
Nucleoside analogs |
June 19, 2001 |
| Novel nucleoside analogs, such as 3-(.beta.-D-Ribofuranosyl)-2-fluoropyridine, 3-(.beta.-D-Ribofuranosyl)-pyridin-2-one, 3-(.beta.-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, 3-(.alpha.-D-Ribofuranosyl)-2-fluoropyridine, 5-(.beta.-D-Ribofuranosyl)-2-bromopyridine, 5- |
| 6239272 |
2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids |
May 29, 2001 |
| A compound having the formula: ##STR1##wherein, R1 represents 2'-O-R.sub.3 -thio-R.sub.3 and/or 2'-C-R.sub.3 -thio-R.sub.3, wherein R.sub.3 is a compound independently selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl, a |
| 6159951 |
2'-O-amino-containing nucleoside analogs and polynucleotides |
December 12, 2000 |
| Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides. |
| 6127535 |
Nucleoside triphosphates and their incorporation into oligonucleotides |
October 3, 2000 |
| Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed. |
| 6117657 |
Non-nucleotide containing enzymatic nucleic acid |
September 12, 2000 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 6093555 |
Amido and peptido modified enzymatic nucleic acid molecules |
July 25, 2000 |
| Oligonucleotide comprising a nucleotide base having the formula: ##STR1## wherein B is a nucleotide base or hydrogen; R.sub.1, R.sub.2 and R.sub.3 independently is selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an am |
| 5998203 |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
December 7, 1999 |
| An enzymatic nucleic acid molecule comprising a 5'- and/or a 3'-cap structure, wherein said structure is not a 5'-5'-linked inverted nucleotide or a 3'-3'-linked inverted nucleotide. |
| 5985621 |
2'-deoxy-2'-alkylnucleotide containing nucleic acid |
November 16, 1999 |
| 2'-deoxy-2'-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules. |
| 5962675 |
Chemical syntheses of 2'-O-methoxy purine nucleosides |
October 5, 1999 |
| Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed. |
| 5891684 |
Base-modified enzymatic nucleic acid |
April 6, 1999 |
| Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core. |
| 5891683 |
Non-nucleotide containing enzymatic nucleic acid |
April 6, 1999 |
| Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule. |
| 5879938 |
Base-modified enzymatic nucleic acid |
March 9, 1999 |
| Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core. |
| 5840876 |
2'-O-alkylthioalkyl and 2'-C-alkylthioalkyl-containing nucleic acids |
November 24, 1998 |
| A compound having the formula: ##STR1## wherein, R1 represents 2'-O-R.sub.3 -thio-R.sub.3 and/or 2'-C-R.sub.3 -thio-R.sub.3, wherein R.sub.3 is independently a compound selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic ar |
| 5783425 |
Amino and peptido modified enzymatic nucleic acid |
July 21, 1998 |
| An enzymatic nucleic acid molecule, comprising a moiety having the formula: ##STR1## wherein B is a nucleotide base or hydrogen; R is selected from the group consisting of aminoacyl group, and NHR.sub.4 group, wherein said R.sub.4 is independently selected from the group consisting o |
| 5767263 |
Base-modified enzymatic nucleic acid |
June 16, 1998 |
| Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core. |
| 5716824 |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes) |
February 10, 1998 |
| A compound having the formula: ##STR1## wherein, R1 represents 2'-O-R.sub.3 -thio-R.sub.3 and/or 2'-C-R.sub.3 -thio-R.sub.3, wherein R.sub.3 is independently a moiety selected from a group consisting of alkyl, alkenyl, alkynyl, aryl, alkylaryl, carbocyclic aryl, heterocyclic aryl |
| 5672511 |
Base-modified enzymatic nucleic acid |
September 30, 1997 |
| Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core. |
